PDE

Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.

Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).

Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).

Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.

Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.

Trapidil (Avantrin) is a coronary vasodilator agent.

Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.

EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).

Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential

ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.

N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.

ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).

NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.

ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.

(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.

BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.

Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.

PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.

WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.

FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.

Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.

UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.

Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.

Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.

Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.

BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).

Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.

Menabitan dihydrochloride (SP-204 dihydrochloride), the dihydrochloride salt of Menabitan, serves as a non-opioid analgesic agent by inhibiting phosphodiesterase 9 (PDE 9). Additionally, it has been shown to reduce intraocular pressure in a rabbit model .

JNJ 42396302 is an effective PDE10A inhibitor that enhances motility and viability in human sperm cells.

PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.

OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.

Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.

PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.

Autotaxin modulator 1 is a new modulator of Autotaxin.

α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.

Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.

ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.

Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.

Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.

Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.

Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.

N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.

Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.

ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.

BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, reduces plasma LPA levels.

DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).