PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 169 products of "PDE"
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ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Color and Shape:Lyophilized PowderMolecular weight:56 kDa (predicted); 56 kDa (reducing conditions)D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Formula:C21H19ClN2O2Purity:97.57%Color and Shape:SolidMolecular weight:366.84Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Formula:C30H33FN8O2SPurity:97% - 99.85%Color and Shape:SolidMolecular weight:588.7Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Formula:C17H14Cl2F2N2O4Purity:98.19% - 99.69%Color and Shape:SolidMolecular weight:419.21Ref: TM-T4462
1mg34.00€2mg49.00€5mg71.00€10mg94.00€25mg161.00€50mg259.00€100mg333.00€500mg797.00€1mL*10mM (DMSO)65.00€Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Formula:C24H19BFNO5SPurity:99.18%Color and Shape:SolidMolecular weight:463.29Ref: TM-T11533
1mg34.00€5mg71.00€10mg101.00€25mg200.00€50mg321.00€100mg475.00€200mg680.00€1mL*10mM (DMSO)73.00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purity:99.70%Color and Shape:SolidMolecular weight:251.05GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Formula:C29H27F3N4O7SColor and Shape:SolidMolecular weight:632.61Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Formula:C25H36N6O4SPurity:99.90%Color and Shape:Off-White SolidMolecular weight:516.66Ref: TM-T17199
5mg50.00€10mg80.00€25mg140.00€50mg219.00€100mg319.00€200mg457.00€1mL*10mM (DMSO)52.00€GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFormula:C27H26N4O5SPurity:99.60% - 99.66%Color and Shape:SolidMolecular weight:518.58IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFormula:C10H14N4O2Purity:98% - >99.99%Color and Shape:Off-WhiteMolecular weight:222.24ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurity:99.70%Color and Shape:White SolidMolecular weight:207.23Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Formula:C21H17N3O4Purity:99.42%Color and Shape:SolidMolecular weight:375.38Ref: TM-T6147
1mg34.00€2mg49.00€5mg74.00€10mg105.00€25mg192.00€50mg334.00€100mg537.00€200mg762.00€500mg1,134.00€1mL*10mM (DMSO)82.00€Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Formula:C20H25NO4Purity:97.37% - 99.52%Color and Shape:White SolidMolecular weight:343.42Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Formula:C23H32N6O4SPurity:99.88%Color and Shape:White SolidMolecular weight:488.6Ref: TM-T8919
2mg39.00€5mg60.00€10mg96.00€25mg177.00€50mg266.00€100mg371.00€200mg523.00€1mL*10mM (DMSO)73.00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Formula:C13H16O3Purity:99.533%Color and Shape:SolidMolecular weight:220.26Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formula:C12H12N2O2SPurity:98.53%Color and Shape:SolidMolecular weight:248.3K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
Formula:C25H26FN5O2Purity:99.48%Color and Shape:SolidMolecular weight:447.5MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).
Formula:C20H14ClN3Purity:99.77%Color and Shape:SolidMolecular weight:331.8Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Formula:C17H17N3O3SPurity:97.52%Color and Shape:SolidMolecular weight:343.4Ref: TM-T7888
1mg126.00€5mg260.00€10mg394.00€25mg677.00€50mg954.00€100mg1,288.00€1mL*10mM (DMSO)286.00€Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Formula:C21H18N4O4Purity:99.85%Color and Shape:White PowderMolecular weight:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Formula:C22H30N6O4S·xCH4O3SPurity:99.84%Color and Shape:SolidMolecular weight:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formula:C23H32N6O5SPurity:99.92%Color and Shape:SolidMolecular weight:504.6Ref: TM-T7346
2mg35.00€5mg50.00€10mg81.00€25mg129.00€50mg187.00€100mg259.00€200mg373.00€1mL*10mM (DMSO)56.00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurity:99.5%Color and Shape:SolidMolecular weight:391.45PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.
Formula:C22H21N5O3Purity:99.86%Color and Shape:SolidMolecular weight:403.43Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Formula:C26H24N4O5Purity:97.03% - 99.29%Color and Shape:SolidMolecular weight:472.49THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Formula:C23H21ClN6O3Purity:99.46%Color and Shape:SolidMolecular weight:464.9Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purity:98% - 99.79%Color and Shape:SolidMolecular weight:428.42Ref: TM-T1745
1mg37.00€2mg50.00€5mg74.00€10mg87.00€25mg147.00€50mg244.00€100mg421.00€200mg617.00€1mL*10mM (DMSO)74.00€Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Formula:C16H17N5O2Purity:99.93%Color and Shape:SolidMolecular weight:311.34Ref: TM-T8515
1mg35.00€2mg52.00€5mg77.00€10mg113.00€25mg178.00€50mg333.00€100mg495.00€200mg710.00€1mL*10mM (DMSO)85.00€PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Formula:C21H19N7Purity:99.65%Color and Shape:SolidMolecular weight:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purity:98.98%Color and Shape:SolidMolecular weight:375.34Ref: TM-T9239
1mg84.00€5mg168.00€10mg245.00€25mg404.00€50mg567.00€100mg767.00€200mg1,018.00€1mL*10mM (DMSO)177.00€Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Formula:C15H22N2O3Purity:98.82% - 99.79%Color and Shape:SolidMolecular weight:278.35ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Formula:C20H20N4O4SPurity:97.93%Color and Shape:SolidMolecular weight:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Formula:C21H19N7Purity:99.29%Color and Shape:SolidMolecular weight:369.42Ref: TM-T8454
1mg62.00€5mg123.00€10mg180.00€25mg298.00€50mg419.00€100mg567.00€200mg752.00€1mL*10mM (DMSO)136.00€MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purity:99.45%Color and Shape:SolidMolecular weight:313.74Ref: TM-T21965
5mg47.00€10mg80.00€25mg145.00€50mg233.00€100mg335.00€200mg467.00€1mL*10mM (DMSO)49.00€BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purity:99.45%Color and Shape:SolidMolecular weight:257.27Ref: TM-T5101
1mg37.00€5mg96.00€10mg144.00€25mg235.00€50mg339.00€100mg480.00€200mg658.00€1mL*10mM (DMSO)42.00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurity:99.83% - >99.99%Color and Shape:White SolidMolecular weight:230.31HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurity:98.26% - ≥95%Color and Shape:SolidMolecular weight:463.29Ref: TM-T2646
2mg37.00€5mg54.00€10mg88.00€25mg138.00€50mg222.00€100mg334.00€200mg500.00€1mL*10mM (DMSO)55.00€YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurity:99.84%Color and Shape:SolidMolecular weight:313.78Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurity:99.68%Color and Shape:SolidMolecular weight:250.26Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Formula:C20H26N2O3Purity:98.87%Color and Shape:White To Off-White SolidMolecular weight:342.43CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purity:99.39%Color and Shape:SolidMolecular weight:454.42,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurity:98.60%Color and Shape:SolidMolecular weight:320.14Ref: TM-T50062
1mg52.00€2mg71.00€5mg98.00€10mg146.00€25mg243.00€50mg355.00€100mg507.00€200mg690.00€1mL*10mM (DMSO)102.00€RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purity:99.25%Color and Shape:SolidMolecular weight:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Formula:C9H12N2O4SPurity:99.66%Color and Shape:SolidMolecular weight:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purity:98.28% - 99.57%Color and Shape:SolidMolecular weight:381.25PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purity:98.70% - 99.25%Color and Shape:SolidMolecular weight:478.33HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:99.88%Color and Shape:SolidMolecular weight:463.29Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:477.56Ref: TM-T25376
1mg34.00€5mg93.00€10mg136.00€25mg268.00€50mg429.00€100mg685.00€200mg888.00€1mL*10mM (DMSO)92.00€Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Formula:C25H20N4OPurity:99.81% - 99.94%Color and Shape:SolidMolecular weight:392.45Ref: TM-T16499
1mg43.00€5mg92.00€10mg150.00€25mg235.00€50mg365.00€100mg547.00€200mg783.00€1mL*10mM (DMSO)92.00€Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Formula:C14H6D4BNO3Color and Shape:SolidMolecular weight:255.07
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