PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 169 products of "PDE"
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Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Formula:C25H36N6O4SPurity:99.90%Color and Shape:Off-White SolidMolecular weight:516.66Ref: TM-T17199
5mg50.00€10mg80.00€25mg140.00€50mg219.00€100mg319.00€200mg457.00€1mL*10mM (DMSO)52.00€2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurity:98.60%Color and Shape:SolidMolecular weight:320.14Ref: TM-T50062
1mg52.00€2mg71.00€5mg98.00€10mg146.00€25mg243.00€50mg355.00€100mg507.00€200mg690.00€1mL*10mM (DMSO)102.00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:99.88%Color and Shape:SolidMolecular weight:463.29PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purity:98.70% - 99.25%Color and Shape:SolidMolecular weight:478.33IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFormula:C10H14N4O2Purity:98% - >99.99%Color and Shape:Off-WhiteMolecular weight:222.24Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Formula:C24H19BFNO5SPurity:99.18%Color and Shape:SolidMolecular weight:463.29Ref: TM-T11533
1mg34.00€5mg71.00€10mg101.00€25mg200.00€50mg321.00€100mg475.00€200mg680.00€1mL*10mM (DMSO)73.00€MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purity:99.45%Color and Shape:SolidMolecular weight:313.74Ref: TM-T21965
5mg47.00€10mg80.00€25mg145.00€50mg233.00€100mg335.00€200mg467.00€1mL*10mM (DMSO)49.00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purity:99.70%Color and Shape:SolidMolecular weight:251.05CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purity:99.39%Color and Shape:SolidMolecular weight:454.4ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurity:99.70%Color and Shape:White SolidMolecular weight:207.23Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Formula:C20H25NO4Purity:97.37% - 99.52%Color and Shape:White SolidMolecular weight:343.42K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
Formula:C25H26FN5O2Purity:99.48%Color and Shape:SolidMolecular weight:447.5[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurity:99.5%Color and Shape:SolidMolecular weight:391.45Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purity:98.28% - 99.57%Color and Shape:SolidMolecular weight:381.25GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFormula:C27H26N4O5SPurity:99.60% - 99.66%Color and Shape:SolidMolecular weight:518.58THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Formula:C23H21ClN6O3Purity:99.46%Color and Shape:SolidMolecular weight:464.9BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Formula:C9H12N2O4SPurity:99.66%Color and Shape:SolidMolecular weight:244.27Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Formula:C21H18N4O4Purity:99.85%Color and Shape:White PowderMolecular weight:390.39Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purity:98% - 99.79%Color and Shape:SolidMolecular weight:428.42Ref: TM-T1745
1mg37.00€2mg50.00€5mg74.00€10mg87.00€25mg147.00€50mg244.00€100mg421.00€200mg617.00€1mL*10mM (DMSO)74.00€RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purity:99.25%Color and Shape:SolidMolecular weight:411.8
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