PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 169 products of "PDE"
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Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Formula:C15H22N2O3Purity:98.82% - 99.79%Color and Shape:SolidMolecular weight:278.35ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Formula:C20H20N4O4SPurity:97.93%Color and Shape:SolidMolecular weight:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Formula:C21H19N7Purity:99.29%Color and Shape:SolidMolecular weight:369.42Ref: TM-T8454
1mg62.00€5mg123.00€10mg180.00€25mg298.00€50mg419.00€100mg567.00€200mg752.00€1mL*10mM (DMSO)136.00€MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purity:99.45%Color and Shape:SolidMolecular weight:313.74Ref: TM-T21965
5mg47.00€10mg80.00€25mg145.00€50mg233.00€100mg335.00€200mg467.00€1mL*10mM (DMSO)49.00€BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purity:99.45%Color and Shape:SolidMolecular weight:257.27Ref: TM-T5101
1mg37.00€5mg96.00€10mg144.00€25mg235.00€50mg339.00€100mg480.00€200mg658.00€1mL*10mM (DMSO)42.00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurity:99.83% - >99.99%Color and Shape:White SolidMolecular weight:230.31HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurity:98.26% - ≥95%Color and Shape:SolidMolecular weight:463.29Ref: TM-T2646
2mg37.00€5mg54.00€10mg88.00€25mg138.00€50mg222.00€100mg334.00€200mg500.00€1mL*10mM (DMSO)55.00€YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurity:99.84%Color and Shape:SolidMolecular weight:313.78Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurity:99.68%Color and Shape:SolidMolecular weight:250.26Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Formula:C20H26N2O3Purity:98.87%Color and Shape:White To Off-White SolidMolecular weight:342.43CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purity:99.39%Color and Shape:SolidMolecular weight:454.42,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurity:98.60%Color and Shape:SolidMolecular weight:320.14Ref: TM-T50062
1mg52.00€2mg71.00€5mg98.00€10mg146.00€25mg243.00€50mg355.00€100mg507.00€200mg690.00€1mL*10mM (DMSO)102.00€RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purity:99.25%Color and Shape:SolidMolecular weight:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Formula:C9H12N2O4SPurity:99.66%Color and Shape:SolidMolecular weight:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purity:98.28% - 99.57%Color and Shape:SolidMolecular weight:381.25PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purity:98.70% - 99.25%Color and Shape:SolidMolecular weight:478.33HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurity:99.88%Color and Shape:SolidMolecular weight:463.29Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:477.56Ref: TM-T25376
1mg34.00€5mg93.00€10mg136.00€25mg268.00€50mg429.00€100mg685.00€200mg888.00€1mL*10mM (DMSO)92.00€Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Formula:C25H20N4OPurity:99.81% - 99.94%Color and Shape:SolidMolecular weight:392.45Ref: TM-T16499
1mg43.00€5mg92.00€10mg150.00€25mg235.00€50mg365.00€100mg547.00€200mg783.00€1mL*10mM (DMSO)92.00€Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Formula:C14H6D4BNO3Color and Shape:SolidMolecular weight:255.07
