PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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PF-05180999
CAS:1394033-54-5
α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.
Formula:
C19H17F3N8
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
414.39
Ref: TM-T16484
| 2mg | 93.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the …
Color and Shape:
Liquid
Molecular weight:
56 kDa (predicted); 56 kDa (reducing conditions)
Ref: TM-TMPY-01588
| 50µg | 588.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Vardenafil
CAS:224785-90-4
Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction.
Formula:
C23H32N6O4S
Purity:
99.88%
Color and Shape:
Solid
Molecular weight:
488.6
Ref: TM-T0096
| 1g | 223.00 € | ||
| 25mg | 37.00 € | ||
| 50mg | 52.00 € | ||
| 100mg | 74.00 € | ||
| 500mg | 157.00 € | ||
| 1mL*10mM (DMSO) | 46.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
N-Ethyl tadalafil
CAS:1609405-34-6
N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.
Formula:
C23H21N3O4
Purity:
99.444%
Color and Shape:
Solid
Molecular weight:
403.43
Ref: TM-T19998
| 1mg | 35.00 € | ||
| 5mg | 65.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Bay 60-7550
CAS:439083-90-6
Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart …
Formula:
C27H32N4O4
Purity:
98.14%
Color and Shape:
Solid
Molecular weight:
476.57
Ref: TM-T14507
| 1mg | 94.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Ro 20-1724
CAS:29925-17-5
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of …
Formula:
C15H22N2O3
Purity:
98% - 99.14%
Color and Shape:
Solid
Molecular weight:
278.35
Ref: TM-T19706
| 5mg | 47.00 € | ||
| 10mg | 70.00 € | ||
| 25mg | 125.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
PF-8380
CAS:1144035-53-9
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme …
Formula:
C22H21Cl2N3O5
Purity:
99.25% - 99.45%
Color and Shape:
Solid
Molecular weight:
478.33
Ref: TM-T3631
| 10mg | 44.00 € | ||
| 25mg | 88.00 € | ||
| 50mg | 129.00 € | ||
| 100mg | 203.00 € | ||
| 200mg | 300.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
PQ-10
CAS:927691-21-2
PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be …
Formula:
C22H21N5O3
Purity:
99.30%
Color and Shape:
Solid
Molecular weight:
403.43
Ref: TM-T24656
| 2mg | 34.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 164.00 € | ||
| 50mg | 250.00 € | ||
| 100mg | 361.00 € | ||
| 200mg | 525.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Roflumilast N-oxide
CAS:292135-78-5
Roflumilast N-oxide is an inhibitor of PDE type 4.
Formula:
C17H14Cl2F2N2O4
Purity:
99.55% - 99.65%
Color and Shape:
Solid
Molecular weight:
419.21
Ref: TM-T4462
| 1mg | 35.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 98.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 269.00 € | ||
| 100mg | 343.00 € | ||
| 500mg | 822.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Balipodect
CAS:1238697-26-1
Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity …
Formula:
C23H17FN6O2
Purity:
98.97% - 99.28%
Color and Shape:
Solid
Molecular weight:
428.42
Ref: TM-T1745
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 91.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 251.00 € | ||
| 100mg | 435.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Irsogladine
CAS:57381-26-7
Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic …
Formula:
C9H7Cl2N5
Purity:
99.74% - 99.91%
Color and Shape:
White Or Colorless Crystal Or Crystalline Powder Odorless Slightly Bitter
Molecular weight:
256.09
Ref: TM-T6548
| 100mg | 34.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
THPP-1
CAS:1257051-63-0
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 …
Formula:
C23H21ClN6O3
Purity:
99.46%
Color and Shape:
Solid
Molecular weight:
464.9
Ref: TM-T8506
| 5mg | 50.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 150.00 € | ||
| 50mg | 246.00 € | ||
| 100mg | 362.00 € | ||
| 200mg | 516.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
K-Ras-PDEδ-IN-1
CAS:1841464-21-8
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of …
Formula:
C25H26FN5O2
Purity:
99.74%
Color and Shape:
Solid
Molecular weight:
447.5
Ref: TM-T8659
| 1mg | 49.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 148.00 € | ||
| 25mg | 287.00 € | ||
| 50mg | 470.00 € | ||
| 100mg | 721.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Cilomilast
CAS:153259-65-5
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory …
Formula:
C20H25NO4
Purity:
97.37% - 99.43%
Color and Shape:
White Solid
Molecular weight:
343.42
Ref: TM-T6445
| 5mg | 52.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 154.00 € | ||
| 50mg | 265.00 € | ||
| 100mg | 387.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Anagrelide
CAS:68475-42-3
Anagrelide (Xagrid) is a Platelet-reducing Agent.
Formula:
C10H7Cl2N3O
Purity:
100%
Color and Shape:
Solid
Molecular weight:
256.09
Ref: TM-T0160
| 1mg | 72.00 € | ||
| 5mg | 156.00 € | ||
| 10mg | 211.00 € | ||
| 25mg | 328.00 € | ||
| 50mg | 503.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
ICI 63197
CAS:27277-00-5
ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.
Formula:
C9H13N5O
Purity:
99.02%
Color and Shape:
White Solid
Molecular weight:
207.23
Ref: TM-T22851
| 1mg | 52.00 € | ||
| 2mg | 63.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 124.00 € | ||
| 25mg | 290.00 € | ||
| 50mg | 419.00 € | ||
| 100mg | 588.00 € | ||
| 200mg | 790.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
IBMX
CAS:28822-58-4
IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and …
Formula:
C10H14N4O2
Purity:
100% - 99.86%
Color and Shape:
Off-White
Molecular weight:
222.24
Ref: TM-T1713
| 25mg | 32.00 € | ||
| 50mg | 46.00 € | ||
| 100mg | 52.00 € | ||
| 200mg | 93.00 € | ||
| 1mL*10mM (DMSO) | 48.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Vardenafil hydrochloride trihydrate
CAS:330808-88-3
Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and …
Formula:
C23H32N6O4S·HCl·3H2O
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
579.11
Ref: TM-T4097
| 5mg | 46.00 € | ||
| 10mg | 70.00 € | ||
| 25mg | 124.00 € | ||
| 50mg | 185.00 € | ||
| 100mg | 294.00 € | ||
| 200mg | 439.00 € | ||
| 500mg | 704.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Zaprinast
CAS:37762-06-4
Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist.
Formula:
C13H13N5O2
Purity:
99.73%
Color and Shape:
White To Off White Powder
Molecular weight:
271.27
Ref: TM-T2129
| 5mg | 38.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 166.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:473477-26-8
2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.
Formula:
C9H9Cl2F2NO3S
Purity:
95.00%
Color and Shape:
Solid
Molecular weight:
320.14
Ref: TM-T50062
| 1mg | 83.00 € | ||
| 2mg | 109.00 € | ||
| 5mg | 170.00 € | ||
| 10mg | 246.00 € | ||
| 25mg | 422.00 € | ||
| 50mg | 618.00 € | ||
| 100mg | 881.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
