PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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GSK256066 Trifluoroacetate
CAS:1415560-64-3
GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.
Formula:
C29H27F3N4O7S
Color and Shape:
Solid
Molecular weight:
632.61
Ref: TM-T11483
| 2mg | 84.00 € | ||
| 50mg | 672.00 € | ||
| 100mg | 932.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Deltarasin
CAS:1440898-61-2
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for …
Formula:
C40H37N5O
Purity:
99.06%
Color and Shape:
Solid
Molecular weight:
603.75
Ref: TM-T6462
| 2mg | 45.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 130.00 € | ||
| 25mg | 211.00 € | ||
| 50mg | 383.00 € | ||
| 100mg | 607.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
PDE4B-IN-2
CAS:915082-52-9
PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: …
Formula:
C19H18ClN3O2S
Purity:
99.37%
Color and Shape:
Liquid
Molecular weight:
387.88
Ref: TM-T36832
| 1mg | 37.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 213.00 € | ||
| 50mg | 346.00 € | ||
| 100mg | 555.00 € | ||
| 500mg | 1,175.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Dovramilast
CAS:340019-69-4
Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus …
Formula:
C24H28N2O6S
Purity:
98.75% - 99.74%
Color and Shape:
Liquid
Molecular weight:
472.55
Ref: TM-T63056
| 1mg | 122.00 € | ||
| 2mg | 174.00 € | ||
| 5mg | 292.00 € | ||
| 10mg | 463.00 € | ||
| 25mg | 888.00 € | ||
| 50mg | 1,388.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
ATX inhibitor 5
CAS:2402772-45-4
ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.
Formula:
C22H18ClF3N6O
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
474.87
Ref: TM-T10409
| 1mg | 94.00 € | ||
| 5mg | 222.00 € | ||
| 10mg | 356.00 € | ||
| 25mg | 606.00 € | ||
| 50mg | 829.00 € | ||
| 100mg | 1,132.00 € | ||
| 1mL*10mM (DMSO) | 231.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Isomazole
CAS:86315-52-8
Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 …
Formula:
C14H13N3O2S
Purity:
99.12%
Color and Shape:
Solid
Molecular weight:
287.34
Ref: TM-T27632
| 1mg | 141.00 € | ||
| 5mg | 327.00 € | ||
| 10mg | 492.00 € | ||
| 25mg | 798.00 € | ||
| 50mg | 1,100.00 € | ||
| 100mg | 1,477.00 € | ||
| 500mg | 2,960.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Deltasonamide 2
CAS:2088485-34-9
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
Formula:
C30H39ClN6O4S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
647.25
Ref: TM-T10994
| 25mg | 1,410.00 € | ||
| 50mg | 1,852.00 € | ||
| 100mg | 2,338.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Autotaxin-IN-1
CAS:1619971-30-0
Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.
Formula:
C21H23N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
405.45
Ref: TM-T14352
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Propentofylline
CAS:55242-55-2
Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study …
Formula:
C15H22N4O3
Purity:
99.11% - 99.42%
Color and Shape:
Off-White Solid
Molecular weight:
306.36
Ref: TM-T19812
| 1mg | 68.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 208.00 € | ||
| 25mg | 351.00 € | ||
| 50mg | 518.00 € | ||
| 100mg | 734.00 € | ||
| 1mL*10mM (DMSO) | 156.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Autotaxin-IN-3
CAS:2156655-68-2
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the …
Formula:
C22H21N9O2
Purity:
98.49% - 99.21%
Color and Shape:
Solid
Molecular weight:
443.46
Ref: TM-T10415
| 1mg | 52.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 103.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 300.00 € | ||
| 50mg | 463.00 € | ||
| 100mg | 744.00 € | ||
| 500mg | 1,482.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Filaminast
CAS:141184-34-1
Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which …
Formula:
C15H20N2O4
Purity:
98.44% - 99.64%
Color and Shape:
Solid
Molecular weight:
292.33
Ref: TM-T31792
| 1mg | 369.00 € | ||
| 5mg | 905.00 € | ||
| 10mg | 1,202.00 € | ||
| 25mg | 1,822.00 € | ||
| 50mg | 2,443.00 € | ||
| 100mg | 3,279.00 € | ||
| 1mL*10mM (DMSO) | 830.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Verofylline
CAS:66172-75-6
Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 …
Formula:
C12H18N4O2
Purity:
97.97% - 99.55%
Color and Shape:
Solid
Molecular weight:
250.3
Ref: TM-T35048
| 1mg | 141.00 € | ||
| 5mg | 327.00 € | ||
| 10mg | 492.00 € | ||
| 25mg | 801.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,483.00 € | ||
| 500mg | 2,980.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
AWD 12-281
CAS:257892-33-4
AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study …
Formula:
C22H14Cl2FN3O3
Purity:
99.55% - 99.95%
Color and Shape:
Solid
Molecular weight:
458.27
Ref: TM-T30232
| 1mg | 277.00 € | ||
| 5mg | 681.00 € | ||
| 10mg | 931.00 € | ||
| 25mg | 1,434.00 € | ||
| 50mg | 1,867.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Mopidamol
CAS:13665-88-8
Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents …
Formula:
C19H31N7O4
Purity:
99.42% - 99.51%
Color and Shape:
Solid
Molecular weight:
421.49
Ref: TM-T25829
| 1mg | 353.00 € | ||
| 5mg | 831.00 € | ||
| 10mg | 1,142.00 € | ||
| 25mg | 1,699.00 € | ||
| 50mg | 2,032.00 € | ||
| 100mg | 2,600.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Tofimilast
CAS:185954-27-2
Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic …
Formula:
C18H21N5S
Purity:
99.94%
Color and Shape:
Solid
Molecular weight:
339.46
Ref: TM-T28991
| 1mg | 141.00 € | ||
| 5mg | 325.00 € | ||
| 10mg | 494.00 € | ||
| 25mg | 797.00 € | ||
| 50mg | 1,096.00 € | ||
| 100mg | 1,476.00 € | ||
| 500mg | 2,962.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
PDE9-IN-1
CAS:2305087-92-5
PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).
Formula:
C17H23FN6O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
362.4
Ref: TM-T12395
| 1mg | 55.00 € | ||
| 5mg | 117.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 323.00 € | ||
| 50mg | 479.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
MK-0873
CAS:500355-52-2
MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.
Formula:
C25H18N4O3
Purity:
99.29%
Color and Shape:
Solid
Molecular weight:
422.44
Ref: TM-T33422
| 1mg | 141.00 € | ||
| 5mg | 327.00 € | ||
| 10mg | 496.00 € | ||
| 25mg | 803.00 € | ||
| 50mg | 1,095.00 € | ||
| 100mg | 1,476.00 € | ||
| 500mg | 2,960.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Dasantafil
CAS:569351-91-3
Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and …
Formula:
C22H28BrN5O5
Purity:
98.64% - 99.16%
Color and Shape:
Solid
Molecular weight:
522.39
Ref: TM-T27122
| 2mg | 34.00 € | ||
| 10mg | To inquire |
Estimated delivery in United States, on Tuesday 21 Jan 2025
TyK2-IN-2
CAS:2098466-94-3
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM …
Formula:
C16H18N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
310.35
Ref: TM-T13232
| 5mg | 419.00 € | ||
| 25mg | 1,382.00 € | ||
| 50mg | 1,803.00 € | ||
| 100mg | 2,583.00 € | ||
| 1mL*10mM (DMSO) | 305.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
PF-04822163
CAS:1798334-07-2
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
Formula:
C19H17ClN2O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
340.8
Ref: TM-T28367
| 1mg | 326.00 € | ||
| 5mg | 769.00 € | ||
| 50mg | 1,838.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
