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PDE

PDE

Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.

Found 165 products of "PDE"

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  • K134
    Targetmol
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    K134

    CAS:
    <p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, &gt;300 and &gt;300 μM, respectively.</p>
    Formula:C22H29N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:399.48

    Ref: TM-T15640

  • PAT-048
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    PAT-048

    CAS:
    <p>PAT-048 is an effective and selective autotaxin inhibitor.</p>
    Formula:C22H18ClF2N3O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.91

    Ref: TM-T16434

  • Propentofylline
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    Propentofylline

    CAS:
    <p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>
    Formula:C15H22N4O3
    Purity:99.76% - 99.86%
    Color and Shape:Off-White Solid
    Molecular weight:306.36

    Ref: TM-T19812

  • Deltasonamide 2
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    Deltasonamide 2

    CAS:
    <p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>
    Formula:C30H39ClN6O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:647.25

    Ref: TM-T10994

  • Deltasonamide 2 (TFA)
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    Deltasonamide 2 (TFA)

    CAS:
    <p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>
    Formula:C32H40ClF3N6O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:761.28

    Ref: TM-T10994L2

  • PDE9-IN-1
    Targetmol
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    PDE9-IN-1

    CAS:
    <p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>
    Formula:C17H23FN6O2
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:362.4

    Ref: TM-T12395

  • Tilivapram
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    Tilivapram

    CAS:
    <p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>
    Formula:C16H15Cl2N3O4
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:384.21

    Ref: TM-T34880

  • AN3199
    Targetmol
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    AN3199

    CAS:
    <p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>
    Formula:C17H18BNO5
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:327.14

    Ref: TM-T10316

  • Imazodan hydrochloride
    Targetmol
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    Imazodan hydrochloride

    CAS:
    <p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>
    Formula:C13H13ClN4O
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:276.72

    Ref: TM-T27596

  • BAY 73-6691
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    BAY 73-6691

    CAS:
    <p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>
    Formula:C15H12ClF3N4O
    Color and Shape:Solid
    Molecular weight:356.73

    Ref: TM-T10481L

  • Lirimilast
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    Lirimilast

    CAS:
    <p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>
    Formula:C17H12Cl2N2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:443.26

    Ref: TM-T15766

  • WAY127093B racemate
    Targetmol
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    WAY127093B racemate

    CAS:
    <p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>
    Formula:C23H28N4O4
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:424.49

    Ref: TM-T13331

  • PDE7-IN-2
    Targetmol
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    PDE7-IN-2

    CAS:
    <p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>
    Formula:C14H11ClN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:322.77

    Ref: TM-T22491

  • (R)-DNMDP
    Targetmol
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    (R)-DNMDP

    CAS:
    <p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>
    Formula:C15H20N4O3
    Color and Shape:Solid
    Molecular weight:304.34

    Ref: TM-T13856

  • Autotaxin-IN-1
    Targetmol
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    Autotaxin-IN-1

    CAS:
    <p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>
    Formula:C21H23N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:405.45

    Ref: TM-T14352

  • Senazodan hydrochloride
    Targetmol
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    Senazodan hydrochloride

    CAS:
    <p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>
    Formula:C15H15ClN4O
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:302.76

    Ref: TM-T28752

  • KD-027
    Targetmol
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    KD-027

    CAS:
    <p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>
    Formula:C25H35N7O6S
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:561.65

    Ref: TM-T27720

  • ATX inhibitor 5
    Targetmol
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    ATX inhibitor 5

    CAS:
    <p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>
    Formula:C22H18ClF3N6O
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:474.87

    Ref: TM-T10409

  • PF-04822163
    Targetmol
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    PF-04822163

    CAS:
    <p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>
    Formula:C19H17ClN2O2
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:340.8

    Ref: TM-T28367

  • Imazodan
    Targetmol
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    Imazodan

    CAS:
    <p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>
    Formula:C13H12N4O
    Purity:98% - 98.31%
    Color and Shape:Solid
    Molecular weight:240.26

    Ref: TM-T71744