Glucokinase
Glucokinase (GK) is an enzyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. GK is predominantly expressed in the liver and pancreas, where it plays a key role in regulating blood glucose levels. Inhibitors of GK are of interest in the study of metabolic disorders such as diabetes, as they can modulate glucose metabolism and insulin secretion. At CymitQuimica, we provide glucokinase inhibitors to support your research in diabetes, metabolism, and therapeutic development.
Found 53 products of "Glucokinase"
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MitoPQ
CAS:<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>Formula:C39H46I3N2PPurity:99.91% - ≥98%Color and Shape:SolidMolecular weight:954.48WAY-640509
CAS:<p>WAY-640509 is a glucocerebrosidase inhibitor.</p>Formula:C25H23N5O4SPurity:99.36%Color and Shape:SolidMolecular weight:489.55Dorzagliatin
CAS:<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>Formula:C22H27ClN4O5Purity:98.67% - 99.45%Color and Shape:SolidMolecular weight:462.93KAN0438757
CAS:<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>Formula:C21H18FNO7SPurity:99.34%Color and Shape:SolidMolecular weight:447.43MK-0941 free base
CAS:<p>MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.</p>Formula:C21H24N4O6SPurity:98.75%Color and Shape:SolidMolecular weight:460.5Oxfendazole
CAS:<p>Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.</p>Formula:C15H13N3O3SPurity:98.99% - 99.17%Color and Shape:White To Yellowish PowderMolecular weight:315.35ADP-specific glucokinase
CAS:<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>Color and Shape:SolidML266
CAS:<p>ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.</p>Formula:C24H22BrN3O4Purity:99.58%Color and Shape:SolidMolecular weight:496.35(1S,2R)-Globalagliatin
CAS:<p>(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.</p>Formula:C28H37N3O3S3Purity:99.09% - >99.99%Color and Shape:SoildMolecular weight:559.81ML251
CAS:<p>ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.</p>Formula:C17H13Cl2N3O4SPurity:99.87%Color and Shape:SolidMolecular weight:426.27AP-III-a4 hydrochloride
CAS:<p>AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.</p>Formula:C31H44ClFN8O3Purity:98%Color and Shape:SolidMolecular weight:631.18Anti-Glucokinase Antibody (5Q209)
<p>Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.</p>Color and Shape:Odour Liquid5MPN
CAS:<p>5MPN is a PFKFB4 inhibitor that inhibits the F6P binding site and suppresses the proliferation of myeloma cells.</p>Formula:C15H19N3O4Purity:98.92% - 99.69%Color and Shape:SolidMolecular weight:305.33Glucokinase Protein, Human, Recombinant
<p>Glucokinase belongs to the bacterial glucokinase family.</p>Color and Shape:Lyophilized PowderMolecular weight:52.2 kDa (predicted); 52.2 kDa (reducing conditions)PF-04991532
CAS:<p>PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.</p>Formula:C18H19F3N4O3Purity:99.99%Color and Shape:SolidMolecular weight:396.36Cadisegliatin
CAS:<p>Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.</p>Formula:C21H33N3O4S2Color and Shape:SolidMolecular weight:455.63Anti-Glucokinase Antibody (3U461)
<p>Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.</p>Color and Shape:Odour LiquidML198
CAS:<p>ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.</p>Formula:C17H14N4OPurity:98.31%Color and Shape:SolidMolecular weight:290.32Globalagliatin
CAS:<p>Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.</p>Formula:C28H37N3O3S3Purity:98% - 99.49%Color and Shape:SolidMolecular weight:559.81AM-2394
CAS:<p>AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.</p>Formula:C22H25N5O4Purity:99.01% - 99.62%Color and Shape:SolidMolecular weight:423.463PO
CAS:<p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>Formula:C13H10N2OPurity:99.56% - 99.67%Color and Shape:SolidMolecular weight:210.23Palmitelaidic Acid
CAS:<p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>Formula:C16H30O2Purity:99.76%Color and Shape:SolidMolecular weight:254.41(E)-3PO
CAS:<p>(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.</p>Formula:C13H10N2OPurity:98.8% - 98.92%Color and Shape:SolidMolecular weight:210.23PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Formula:C17H12N2OPurity:99.7% - 99.85%Color and Shape:SolidMolecular weight:260.29Genz-123346 free base
CAS:<p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>Formula:C24H38N2O4Purity:99.41%Color and Shape:SolidMolecular weight:418.57AMG-3969
CAS:<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>Formula:C21H20F6N4O3SPurity:99.65%Color and Shape:SolidMolecular weight:522.46Glucokinase activator 3
CAS:<p>Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.</p>Formula:C26H33N2O9PS2Color and Shape:SolidMolecular weight:612.65RO-28-1675
CAS:<p>RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.</p>Formula:C18H22N2O3S2Purity:98.13%Color and Shape:SolidMolecular weight:378.51PSN-GK1
CAS:<p>PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).</p>Formula:C20H23FN2O4S2Purity:98%Color and Shape:SolidMolecular weight:438.54GKA-22
CAS:<p>GKA-22 is a human glucokinase allosteric activator in the absence of glucose.</p>Formula:C22H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:426.49Piragliatin
CAS:<p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>Formula:C19H20ClN3O4SColor and Shape:SolidMolecular weight:421.9Glucokinase activator 1
CAS:<p>Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).</p>Formula:C27H20F2N2O7S2Purity:98%Color and Shape:SolidMolecular weight:586.58IHVR-11029
CAS:<p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>Formula:C18H27F2NO5Color and Shape:SolidMolecular weight:375.41GKA-71
CAS:<p>GKA-71 is an effective glucokinase activator (GKA).</p>Formula:C21H23N3O6S2Color and Shape:SolidMolecular weight:477.55PF-04279405
CAS:<p>PF-04279405 is a potent and selective glucokinase activator.</p>Formula:C25H25FN4O4Color and Shape:SolidMolecular weight:464.49Cefetrizole
CAS:<p>Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).</p>Formula:C16H15N5O4S3Purity:98%Color and Shape:SolidMolecular weight:437.52YZ9
CAS:<p>Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].</p>Formula:C12H10O5Purity:99.59%Color and Shape:SolidMolecular weight:234.2AMG-1694
CAS:<p>AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.</p>Formula:C23H30F3N3O4S2Purity:98.37%Color and Shape:SolidMolecular weight:533.63AR453588
CAS:<p>AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Formula:C25H25N7O2S2Color and Shape:SolidMolecular weight:519.64KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Formula:C25H26N6OPurity:98%Color and Shape:SolidMolecular weight:426.51AR453588 hydrochloride
CAS:<p>AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Formula:C25H26ClN7O2S2Purity:98%Color and Shape:SolidMolecular weight:556.1CM-10-18
CAS:<p>CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.</p>Formula:C17H35NO5Color and Shape:SolidMolecular weight:333.46PF-04937319
CAS:<p>PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.</p>Formula:C22H20N6O4Purity:99.89%Color and Shape:SolidMolecular weight:432.43AZD-1656
CAS:<p>AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2</p>Formula:C24H26N6O5Purity:97.07% - 99.37%Color and Shape:SolidMolecular weight:478.5AZD1092
CAS:<p>AZD1092 is the glucokinase enzyme activator.</p>Formula:C24H26N4O5Purity:98%Color and Shape:SolidMolecular weight:450.49WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Formula:C13H13ClN2O2SPurity:98.19%Color and Shape:SolidMolecular weight:296.77Glucokinase activator 7
CAS:<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Formula:C26H30N2O7Color and Shape:SolidMolecular weight:469.01Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Formula:C21H24N4O2Purity:99.51% - 99.76%Color and Shape:SolidMolecular weight:364.44Glucokinase activator 8
CAS:<p>Glucokinase activator8 is an activator of glucose kinase (glucokinase).</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337
