Glucokinase
Glucokinase (GK) is an enzyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. GK is predominantly expressed in the liver and pancreas, where it plays a key role in regulating blood glucose levels. Inhibitors of GK are of interest in the study of metabolic disorders such as diabetes, as they can modulate glucose metabolism and insulin secretion. At CymitQuimica, we provide glucokinase inhibitors to support your research in diabetes, metabolism, and therapeutic development.
Found 56 products of "Glucokinase"
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GKA-22
CAS:GKA-22 is a human glucokinase allosteric activator in the absence of glucose.Formula:C22H22N2O5SPurity:98%Color and Shape:SolidMolecular weight:426.49AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Formula:C23H30F3N3O4S2Purity:98.37%Color and Shape:SolidMolecular weight:533.63CM-10-18
CAS:CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.Formula:C17H35NO5Color and Shape:SolidMolecular weight:333.46AZD-1656
CAS:AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2Formula:C24H26N6O5Purity:97.07% - 99.37%Color and Shape:SolidMolecular weight:478.5AZD1092
CAS:AZD1092 is the glucokinase enzyme activator.Formula:C24H26N4O5Purity:98%Color and Shape:SolidMolecular weight:450.49AR453588
CAS:AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Formula:C25H25N7O2S2Color and Shape:SolidMolecular weight:519.64PF-04937319
CAS:PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.Formula:C22H20N6O4Purity:99.89%Color and Shape:SolidMolecular weight:432.43KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formula:C25H26N6OPurity:98%Color and Shape:SolidMolecular weight:426.51AR453588 hydrochloride
CAS:AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Formula:C25H26ClN7O2S2Purity:98%Color and Shape:SolidMolecular weight:556.1WAY-297848
CAS:WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.Formula:C13H13ClN2O2SPurity:98.19%Color and Shape:SolidMolecular weight:296.77Glucokinase activator 7
CAS:Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337GKA50 quarterhydrate
GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.Formula:C26H30N2O7Color and Shape:SolidMolecular weight:469.01Gcase activator 2
CAS:Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.Formula:C21H24N4O2Purity:99.51% - 99.76%Color and Shape:SolidMolecular weight:364.44Glucokinase activator 8
CAS:Glucokinase activator8 is an activator of glucose kinase (glucokinase).Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.337MK-0941
CAS:MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.Formula:C22H28N4O9S2Color and Shape:SolidMolecular weight:556.61GKA50
CAS:GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).Formula:C26H28N2O6Purity:98%Color and Shape:SolidMolecular weight:464.51
