HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 142 products of "HIF/HIF Prolyl-Hydroxylase"
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FG-2216
CAS:<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Formula:C12H9ClN2O4Purity:97.1% - >99.99%Color and Shape:SolidMolecular weight:280.66N-Oxalylglycine
CAS:<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Formula:C4H5NO5Purity:99.23%Color and Shape:Colourless SolidMolecular weight:147.09IDF-11774
CAS:<p>IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).</p>Formula:C23H32N2O2Purity:98.05%Color and Shape:SolidMolecular weight:368.51IOX2
CAS:<p>IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.</p>Formula:C19H16N2O5Purity:98% - 99.59%Color and Shape:SolidMolecular weight:352.34ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formula:C20H21N5O2Purity:99.8%Color and Shape:SolidMolecular weight:363.41Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25M1001
CAS:<p>M1001 is a HIF-2α agonist.</p>Formula:C17H17N3O2SPurity:98.83%Color and Shape:SolidMolecular weight:327.4Deoxyshikonin
CAS:<p>1.</p>Formula:C16H16O4Purity:99.36% - ≥95%Color and Shape:SolidMolecular weight:272.3VH-298
CAS:<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Formula:C27H33N5O4SPurity:99.17% - >99.99%Color and Shape:SolidMolecular weight:523.65PHD-1-IN-1
CAS:<p>PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).</p>Formula:C13H8N4Purity:99.74%Color and Shape:SolidMolecular weight:220.23GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formula:C18H15N3O2Purity:99.52%Color and Shape:SolidMolecular weight:305.33B2
CAS:<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Formula:C20H17ClN4O3Purity:99.66%Color and Shape:SolidMolecular weight:396.83BAY 87-2243
CAS:<p>BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).</p>Formula:C26H26F3N7O2Purity:98% - 99.95%Color and Shape:SolidMolecular weight:525.53Chlorogenic Acid
CAS:<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Formula:C16H18O9Purity:98.84% - 99.67%Color and Shape:SolidMolecular weight:354.31JNJ-42041935
CAS:<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Formula:C12H6ClF3N4O3Purity:99.58% - ≥95%Color and Shape:SolidMolecular weight:346.65dencichine
CAS:<p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>Formula:C5H8N2O5Purity:99.93% - ≥95%Color and Shape:SolidMolecular weight:176.13Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formula:C21H25ClO6Purity:99.5% - 99.93%Color and Shape:SolidMolecular weight:408.87DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formula:C6H9NO5Purity:80.23% - 99.98%Color and Shape:SolidMolecular weight:175.14MK-8617
CAS:<p>MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).</p>Formula:C24H21N5O4Purity:99.38% - >99.99%Color and Shape:SolidMolecular weight:443.45KC7F2
CAS:<p>KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.</p>Formula:C16H16Cl4N2O4S4Purity:98% - 99.11%Color and Shape:SolidMolecular weight:570.38
