HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
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HIF-2α-IN-4
CAS:882268-69-1
HIF-2a translation inhibitor is a compound used as a molecular building block.
Formula:
C9H9N3O4S2
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
287.32
Ref: TM-T50099
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 186.00 € | ||
| 50mg | 349.00 € | ||
| 100mg | 522.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
PT-2385
CAS:1672665-49-4
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
Formula:
C17H12F3NO4S
Purity:
98.69% - 99.55%
Color and Shape:
Solid
Molecular weight:
383.34
Ref: TM-T7848
| 1mg | 66.00 € | ||
| 2mg | 96.00 € | ||
| 5mg | 150.00 € | ||
| 10mg | 253.00 € | ||
| 25mg | 402.00 € | ||
| 50mg | 596.00 € | ||
| 100mg | 848.00 € | ||
| 1mL*10mM (DMSO) | 125.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Oroxylin A
CAS:480-11-5
Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion …
Formula:
C16H12O5
Purity:
98.72% - 99.55%
Color and Shape:
Solid
Molecular weight:
284.26
Ref: TM-T6S1315
| 20mg | 135.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
IOX4
CAS:1154097-71-8
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
Formula:
C15H16N6O3
Purity:
99.97%
Color and Shape:
Solid
Molecular weight:
328.33
Ref: TM-T7880
| 5mg | 35.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 108.00 € | ||
| 50mg | 189.00 € | ||
| 100mg | 283.00 € | ||
| 200mg | 403.00 € | ||
| 1mL*10mM (DMSO) | 37.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Panaxadiol
CAS:19666-76-3
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
Formula:
C30H52O3
Purity:
98% - 99.9%
Color and Shape:
Solid
Molecular weight:
460.73
Ref: TM-T2763
| 50mg | 54.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
LW6
CAS:934593-90-5
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
Formula:
C26H29NO5
Purity:
98.1% - 99.10%
Color and Shape:
Solid
Molecular weight:
435.51
Ref: TM-T3494
| 2mg | 46.00 € | ||
| 5mg | 68.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 180.00 € | ||
| 50mg | 291.00 € | ||
| 100mg | 439.00 € | ||
| 500mg | 917.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Belzutifan
CAS:1672668-24-4
"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."
Formula:
C17H12F3NO4S
Purity:
99.34% - 99.41%
Color and Shape:
Solid
Molecular weight:
383.34
Ref: TM-T16679
| 1mg | 69.00 € | ||
| 5mg | 149.00 € | ||
| 10mg | 269.00 € | ||
| 25mg | 455.00 € | ||
| 50mg | 664.00 € | ||
| 100mg | 917.00 € | ||
| 1mL*10mM (DMSO) | 165.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Amifostine trihydrate
CAS:112901-68-5
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of …
Formula:
C5H15N2O3PS·3H2O
Purity:
99.61% - ≥98%
Color and Shape:
Solid
Molecular weight:
268.27
Ref: TM-T6381
| 5mg | 36.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 115.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 257.00 € | ||
| 200mg | 410.00 € | ||
| 500mg | 667.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
PX-478
CAS:685898-44-6
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.
Formula:
C13H20Cl4N2O3
Purity:
97% - ≥98%
Color and Shape:
Solid
Molecular weight:
394.12
Ref: TM-T6961
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 134.00 € | ||
| 25mg | 200.00 € | ||
| 50mg | 272.00 € | ||
| 100mg | 427.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Desidustat
CAS:1616690-16-4
Desidustat is an inhibitor of HIF hydroxylase.
Formula:
C16H16N2O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
332.31
Ref: TM-T5176
| 1mg | 35.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 300.00 € | ||
| 50mg | 516.00 € | ||
| 100mg | 732.00 € | ||
| 1ml*10 (DMSO) | 112.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
UNC6934
CAS:2561494-77-5
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
Formula:
C24H21N5O4
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
443.45
Ref: TM-T9584
| 1mg | 85.00 € | ||
| 2mg | 111.00 € | ||
| 5mg | 179.00 € | ||
| 10mg | 280.00 € | ||
| 25mg | 452.00 € | ||
| 50mg | 641.00 € | ||
| 100mg | 875.00 € | ||
| 500mg | 1,745.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Annaosanchun
CAS:4725-51-3
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).
Formula:
C19H32O3
Purity:
99.58%
Color and Shape:
Solid
Molecular weight:
308.46
Ref: TM-T19659
| 1mg | 46.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 221.00 € | ||
| 50mg | 332.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
E3330
CAS:136164-66-4
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
Formula:
C21H30O6
Purity:
98.83%
Color and Shape:
Solid
Molecular weight:
378.46
Ref: TM-T6823
| 1mg | 50.00 € | ||
| 2mg | 71.00 € | ||
| 5mg | 106.00 € | ||
| 10mg | 171.00 € | ||
| 25mg | 300.00 € | ||
| 50mg | 494.00 € | ||
| 100mg | 716.00 € | ||
| 200mg | 1,004.00 € | ||
| 500mg | 1,476.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 15 Jan 2025
HIF-2α-IN-3
CAS:313964-19-1
HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer …
Formula:
C12H6ClN5O5
Color and Shape:
Solid
Molecular weight:
335.66
Ref: TM-T11562
| 1mg | 113.00 € | ||
| 5mg | 268.00 € | ||
| 10mg | 422.00 € | ||
| 25mg | 824.00 € | ||
| 50mg | 1,273.00 € | ||
| 100mg | 1,741.00 € | ||
| 1mL*10mM (DMSO) | 301.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
THS-044
CAS:62054-67-5
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM …
Formula:
C11H12F3N3O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
291.23
Ref: TM-T13925
| 1mg | 79.00 € | ||
| 5mg | 151.00 € | ||
| 10mg | 235.00 € | ||
| 25mg | 384.00 € | ||
| 50mg | 546.00 € | ||
| 100mg | 737.00 € | ||
| 500mg | 1,486.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
FM19G11
CAS:329932-55-0
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in …
Formula:
C23H17N3O8
Purity:
97.28%
Color and Shape:
Solid
Molecular weight:
463.4
Ref: TM-T36711
| 1mg | 51.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 170.00 € | ||
| 25mg | 298.00 € | ||
| 50mg | 470.00 € | ||
| 100mg | 755.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
TC-S 7009
CAS:1422955-31-4
TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene …
Formula:
C12H6ClFN4O3
Purity:
100% - 99.71%
Color and Shape:
Solid
Molecular weight:
308.65
Ref: TM-T17009
| 5mg | 69.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 231.00 € | ||
| 50mg | 344.00 € | ||
| 100mg | 507.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
M1002
CAS:823830-85-9
M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.
Formula:
C15H8F6N2O2S
Purity:
99.73%
Color and Shape:
Liquid
Molecular weight:
394.29
Ref: TM-T61822
| 1mg | 52.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 362.00 € | ||
| 100mg | 536.00 € | ||
| 500mg | 1,106.00 € | ||
| 1mL*10mM (DMSO) | 113.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
TM6089
CAS:863421-32-3
TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces …
Formula:
C13H14N4O3S
Purity:
99.07%
Color and Shape:
Solid
Molecular weight:
306.34
Ref: TM-T17105
| 1mg | 72.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 229.00 € | ||
| 25mg | 413.00 € | ||
| 50mg | 617.00 € | ||
| 100mg | 901.00 € | ||
| 200mg | 1,210.00 € | ||
| 1mL*10mM (DMSO) | 168.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
ZK-261991
CAS:886563-25-3
ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).
Formula:
C24H25N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
443.5
Ref: TM-T13402
| 25mg | 1,406.00 € | ||
| 50mg | 1,852.00 € | ||
| 100mg | 2,338.00 € |
Estimated delivery in United States, on Wednesday 29 Jan 2025
