HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 146 products of "HIF/HIF Prolyl-Hydroxylase"
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GSK360A
CAS:GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.Formula:C17H17FN2O5Purity:98%Color and Shape:SolidMolecular weight:348.33THS-044
CAS:THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activityFormula:C11H12F3N3O3Purity:99.89%Color and Shape:SolidMolecular weight:291.23DM-NOFD
CAS:DM-NOFD is a cell penetrant prodrug of NOFD, which is a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF).Formula:C13H15NO5Color and Shape:SolidMolecular weight:265.26TM6008
CAS:TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.Formula:C21H17N5O3Purity:98%Color and Shape:SolidMolecular weight:387.39KCN1
CAS:KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Formula:C26H27NO5SColor and Shape:SolidMolecular weight:465.56Langkamide
CAS:Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.Formula:C16H17NO5Purity:98%Color and Shape:SolidMolecular weight:303.31103D5R
CAS:103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.4HIF-IN-33
CAS:HIF-IN-33 is an inhibitor of HIF pathway.Formula:C21H17F3N4O2Purity:98%Color and Shape:SolidMolecular weight:414.38M1002
CAS:M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formula:C15H8F6N2O2SPurity:99.98%Color and Shape:SolidMolecular weight:394.29Ref: TM-T61822
1mg49.00€5mg92.00€10mg144.00€25mg235.00€50mg350.00€100mg515.00€500mg1,071.00€1mL*10mM (DMSO)108.00€Angiogenesis agent 1
CAS:Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4BNS
CAS:BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.Formula:C18H16N2O6S2Purity:98%Color and Shape:SolidMolecular weight:420.46HIF-1/2α-IN-2
CAS:HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.Formula:C16H11FN4O2SColor and Shape:SolidMolecular weight:342.35HIF-PHD-IN-2
CAS:HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].Formula:C17H15N5O3SColor and Shape:SolidMolecular weight:369.4ENMD-1198
CAS:ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.Formula:C20H25NO2Purity:98%Color and Shape:SolidMolecular weight:311.42TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formula:C13H14N4O3SPurity:99.70%Color and Shape:SolidMolecular weight:306.34Ref: TM-T17105
1mg50.00€5mg109.00€10mg164.00€25mg285.00€50mg427.00€100mg623.00€200mg837.00€1mL*10mM (DMSO)116.00€HIF-1α inhibitor-1
CAS:HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.Formula:C15H11N3O4Color and Shape:SolidMolecular weight:297.27HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formula:C12H6ClN5O5Purity:98.11%Color and Shape:SolidMolecular weight:335.66Ref: TM-T11562
1mg73.00€2mg92.00€5mg161.00€10mg245.00€25mg480.00€50mg735.00€100mg999.00€200mg1,333.00€1mL*10mM (DMSO)172.00€TC-S 7009
CAS:TC-S 7009: Strong HIF-2α inhibitor (Kd 81 nM), weak for HIF-1α; disrupts dimerization & gene expression.Formula:C12H6ClFN4O3Purity:99.46% - 99.71%Color and Shape:SolidMolecular weight:308.65KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46CLB-016
CAS:CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.Formula:C17H20N6O3Purity:98%Color and Shape:SolidMolecular weight:356.38
