HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 146 products of "HIF/HIF Prolyl-Hydroxylase"
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MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formula:C24H21N5O4Purity:99.38% - >99.99%Color and Shape:SolidMolecular weight:443.45KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formula:C16H16Cl4N2O4S4Purity:98% - 99.11%Color and Shape:SolidMolecular weight:570.382,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Formula:C11H13NO4Purity:99.74%Color and Shape:Yellow Solid CrystallineMolecular weight:223.23HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Formula:C9H9N3O4S2Purity:≥98%Color and Shape:SolidMolecular weight:287.32Ref: TM-T50099
5mg37.00€10mg60.00€25mg111.00€50mg200.00€100mg299.00€200mg430.00€1mL*10mM (DMSO)44.00€PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formula:C17H12F3NO4SPurity:98.91% - 99.55%Color and Shape:SolidMolecular weight:383.34Ref: TM-T7848
1mg63.00€2mg93.00€5mg144.00€10mg222.00€25mg379.00€50mg532.00€100mg740.00€200mg982.00€1mL*10mM (DMSO)119.00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26Ref: TM-T6S1315
1mg37.00€5mg71.00€10mg90.00€25mg147.00€50mg208.00€100mg309.00€200mg447.00€1mL*10mM (DMSO)84.00€IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formula:C15H16N6O3Purity:99.97%Color and Shape:SolidMolecular weight:328.33Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formula:C26H29NO5Purity:98.1% - 98.22%Color and Shape:SolidMolecular weight:435.51Ref: TM-T3494
2mg44.00€5mg65.00€10mg94.00€25mg173.00€50mg281.00€100mg424.00€500mg888.00€1mL*10mM (DMSO)65.00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formula:C17H12F3NO4SPurity:99.34% - 99.88%Color and Shape:SolidMolecular weight:383.34Ref: TM-T16679
1mg66.00€5mg144.00€10mg205.00€25mg389.00€50mg625.00€100mg888.00€200mg1,198.00€1mL*10mM (DMSO)158.00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formula:C5H15N2O3PS·3H2OPurity:99.71% - 99.80%Color and Shape:SolidMolecular weight:268.27PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formula:C13H20Cl4N2O3Purity:97% - 99.79%Color and Shape:SolidMolecular weight:394.12Ref: TM-T6961
1mg39.00€5mg84.00€10mg130.00€25mg193.00€50mg261.00€100mg411.00€200mg605.00€1mL*10mM (DMSO)84.00€Diethyl bipy55'DC
CAS:"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."Formula:C16H16N2O4Purity:98%Color and Shape:SolidMolecular weight:300.31E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46OHM1
CAS:OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53Formula:C24H42N6O5Color and Shape:SolidMolecular weight:494.63ZK-261991
CAS:ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).Formula:C24H25N7O2Purity:98%Color and Shape:SolidMolecular weight:443.5Dimethyl-bisphenol A
CAS:DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.Formula:C17H20O2Color and Shape:SolidMolecular weight:256.34FM19G11
CAS:FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
Formula:C23H17N3O8Purity:99.70%Color and Shape:SolidMolecular weight:463.4HIF-1α-IN-3
CAS:HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].Formula:C19H17N5O2Color and Shape:SolidMolecular weight:347.37CL67
CAS:CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.Formula:C38H42N10O2Color and Shape:SolidMolecular weight:670.81
