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HIF/HIF Prolyl-Hydroxylase

HIF/HIF Prolyl-Hydroxylase

Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.

Found 142 products of "HIF/HIF Prolyl-Hydroxylase"

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  • HIF-2α-IN-9
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    HIF-2α-IN-9

    CAS:
    <p>HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within</p>
    Formula:C12H13F5O4S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.35

    Ref: TM-T78937

  • PHD-IN-1
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    PHD-IN-1

    CAS:
    <p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>
    Formula:C24H23N7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:441.49

    Ref: TM-T79797

  • AKB-6899
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    AKB-6899

    CAS:
    <p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>
    Formula:C14H11FN2O4
    Purity:97.87%
    Color and Shape:Solid
    Molecular weight:290.25

    Ref: TM-T29797

  • HIF-2α-IN-1
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    HIF-2α-IN-1

    CAS:
    <p>HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.</p>
    Formula:C16H8F5NO4S
    Purity:97.99%
    Color and Shape:Solid
    Molecular weight:405.3

    Ref: TM-T15482

  • CLB-016
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    CLB-016

    CAS:
    <p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>
    Formula:C17H20N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:356.38

    Ref: TM-T23894

  • HIF-2α-IN-6
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    HIF-2α-IN-6

    CAS:
    <p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>
    Formula:C15H13F4NO3S
    Color and Shape:Solid
    Molecular weight:363.33

    Ref: TM-T61367

  • NPAS3-IN-1
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    NPAS3-IN-1

    CAS:
    <p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>
    Formula:C10H5N3O2S3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:295.36

    Ref: TM-T81646

  • HIF-2α agonist 2
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    HIF-2α agonist 2

    CAS:
    <p>HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.</p>
    Formula:C13H8Br2N2O2S
    Purity:98.87%
    Color and Shape:Soild
    Molecular weight:416.09

    Ref: TM-T67831

  • HIF-2α-IN-7
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    HIF-2α-IN-7

    CAS:
    <p>HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.</p>
    Formula:C18H9F6NO2
    Color and Shape:Solid
    Molecular weight:385.26

    Ref: TM-T72997

  • HIF-2α-IN-5
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    HIF-2α-IN-5

    CAS:
    <p>HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of &lt; 50 nM [1].</p>
    Formula:C15H12F4O3S2
    Color and Shape:Solid
    Molecular weight:380.38

    Ref: TM-T61614

  • (Rac)-PT2399
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    (Rac)-PT2399

    CAS:
    <p>(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).</p>
    Formula:C17H10F5NO4S
    Color and Shape:Solid
    Molecular weight:419.32

    Ref: TM-T12675

  • JTZ-951 HCl
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    JTZ-951 HCl

    CAS:
    <p>JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).</p>
    Formula:C17H17ClN4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:376.79

    Ref: TM-T27699

  • AFP464 free base
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    AFP464 free base

    CAS:
    <p>AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.</p>
    Formula:C22H23F3N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.44

    Ref: TM-T10258

  • CymitQuimica logo
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    HIF-1α-IN-5

    <p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>
    Formula:C16H15N3O2
    Color and Shape:Solid
    Molecular weight:281.31

    Ref: TM-T60532

  • DDO-3055
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    DDO-3055

    CAS:
    <p>DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.</p>
    Formula:C17H13ClN2O5
    Color and Shape:Solid
    Molecular weight:360.749

    Ref: TM-T205089

  • JPHM-2-167
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    JPHM-2-167

    CAS:
    <p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>
    Formula:C30H28N6O2
    Color and Shape:Solid
    Molecular weight:504.582

    Ref: TM-T205273

  • CymitQuimica logo
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    HIF-1α-IN-4

    <p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>
    Formula:C16H12N2O3
    Color and Shape:Solid
    Molecular weight:280.28

    Ref: TM-T60524

  • DS44470011
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    DS44470011

    CAS:
    <p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>
    Formula:C21H19N3O4
    Color and Shape:Solid
    Molecular weight:377.39

    Ref: TM-T88182

  • PHD2-IN-4
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    PHD2-IN-4

    CAS:
    <p>PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.</p>
    Formula:C21H19N5O3
    Color and Shape:Solid
    Molecular weight:389.407

    Ref: TM-T205562

  • CymitQuimica logo
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    HIF-1/2α-IN-1

    <p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>
    Formula:C17H16N6O4
    Color and Shape:Solid
    Molecular weight:368.35

    Ref: TM-T61442