HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Found 146 products of "HIF/HIF Prolyl-Hydroxylase"
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PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFormula:C26H27N7O4Purity:98%Color and Shape:SolidMolecular weight:501.54Prolyl Hydroxylase inhibitor 1
CAS:Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).Formula:C19H18ClN5O4Purity:98%Color and Shape:SolidMolecular weight:415.83PHD2-IN-1
CAS:PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Formula:C21H23ClN4O5Purity:98%Color and Shape:SolidMolecular weight:446.88HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49AKB-6899
CAS:AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treatedFormula:C14H11FN2O4Purity:97.87%Color and Shape:SolidMolecular weight:290.25HIF-2α-IN-13
CAS:HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.Formula:C15H14ClF4NO2Color and Shape:SolidMolecular weight:351.72HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formula:C16H8F5NO4SPurity:97.99%Color and Shape:SolidMolecular weight:405.3HIF-2α-IN-6
CAS:HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].Formula:C15H13F4NO3SColor and Shape:SolidMolecular weight:363.33TRC160334 sodium
CAS:TRC160334 is a HIF hydroxylases inhibitor.Formula:C14H15N3O5SColor and Shape:SolidMolecular weight:337.35HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formula:C13H8Br2N2O2SPurity:98.87%Color and Shape:SoildMolecular weight:416.09NPAS3-IN-1
CAS:NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.Formula:C10H5N3O2S3Purity:99.56%Color and Shape:SolidMolecular weight:295.36HIF-2α-IN-7
CAS:HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formula:C18H9F6NO2Color and Shape:SolidMolecular weight:385.26HIF-2α-IN-5
CAS:HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].Formula:C15H12F4O3S2Color and Shape:SolidMolecular weight:380.38JTZ-951 HCl
CAS:JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).Formula:C17H17ClN4O4Purity:98%Color and Shape:SolidMolecular weight:376.79AFP464 free base
CAS:AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Formula:C22H23F3N4O3Purity:98%Color and Shape:SolidMolecular weight:448.44HIF-1α-IN-5
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.Formula:C16H15N3O2Color and Shape:SolidMolecular weight:281.31JPHM-2-167
CAS:PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582HIF-1α-IN-4
HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.Formula:C16H12N2O3Color and Shape:SolidMolecular weight:280.28DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Formula:C17H13ClN2O5Color and Shape:SolidMolecular weight:360.749
