ROR
Retinoic Acid-Related Orphan Receptors (RORs) are nuclear receptors that regulate various physiological processes, including circadian rhythm, immune response, and metabolism. ROR inhibitors are of interest in the study of autoimmune diseases, metabolic disorders, and cancer, as they can modulate gene expression and influence cellular functions. At CymitQuimica, we offer ROR inhibitors to support your research in immunology, endocrinology, and oncology.
Found 42 products of "ROR"
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Bevurogant
CAS:<p>Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.</p>Formula:C26H28N8O3SPurity:99.32%Color and Shape:SolidMolecular weight:532.62RORγ antagonist 1
<p>RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.</p>Formula:C35H60N2O2Purity:98%Color and Shape:SolidMolecular weight:540.86RORγt inverse agonist 33
<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>Formula:C27H37NO5SColor and Shape:SolidMolecular weight:487.651RORγt inverse agonist 31
<p>RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (</p>Formula:C23H15Cl2F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:555.36TMP-778
CAS:<p>TMP-778 is a selective inverse agonist of RORγt.</p>Formula:C31H30N2O4Purity:99.68%Color and Shape:SolidMolecular weight:494.58ROR1 ligand-1
<p>ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.</p>Formula:C23H30BrN7Color and Shape:SolidMolecular weight:484.44ROR1-IN-2
<p>ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.</p>Formula:C30H27N3O4Color and Shape:SolidMolecular weight:493.20016XY018
CAS:<p>XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.</p>Formula:C23H15F7N2O4Purity:99.95% - 99.96%Color and Shape:SolidMolecular weight:516.37TMP920
CAS:<p>TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.</p>Formula:C29H30N2O3Purity:98%Color and Shape:SolidMolecular weight:454.56SR1078
CAS:<p>SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.</p>Formula:C17H10F9NO2Purity:99.58%Color and Shape:SolidMolecular weight:431.25GSK805
CAS:<p>GSK805 is a potent, orally bioavailable and CNS-penetrant RORγt inhibitor.Cost-effective and quality-assured.</p>Formula:C23H18Cl2F3NO4SPurity:98% - ≥95%Color and Shape:SolidMolecular weight:532.36Cintirorgon
CAS:<p>Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.</p>Formula:C27H23F6NO6SPurity:99.92%Color and Shape:SolidMolecular weight:603.53SR1001
CAS:<p>SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).</p>Formula:C15H13F6N3O4S2Purity:98.93%Color and Shape:SolidMolecular weight:477.4GSK2981278
CAS:<p>GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).</p>Formula:C25H35NO5SPurity:99.31% - 99.67%Color and Shape:SolidMolecular weight:461.61RORγt inverse agonist 13
CAS:<p>RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].</p>Formula:C23H17Cl2F3N2O4Purity:99.04%Color and Shape:SolidMolecular weight:513.29Neoruscogenin
CAS:<p>1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.</p>Formula:C27H40O4Purity:99.5% - 99.92%Color and Shape:SolidMolecular weight:428.6S18-000003
CAS:<p>S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.</p>Formula:C26H25F3N2O4SPurity:99.24% - 99.31%Color and Shape:SolidMolecular weight:518.55SR3335
CAS:<p>SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).</p>Formula:C13H9F6NO3S2Purity:99.77%Color and Shape:SolidMolecular weight:405.34T0901317
CAS:<p>T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).</p>Formula:C17H12F9NO3SPurity:98% - 99.64%Color and Shape:SolidMolecular weight:481.33Cedirogant
CAS:<p>Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.</p>Formula:C24H20Cl3F3N2O3Purity:99.20%Color and Shape:SolidMolecular weight:547.78SR0987
CAS:<p>SR0987 is a RORγt agonist,</p>Formula:C16H10ClF6NO2Purity:99.43%Color and Shape:SolidMolecular weight:397.7Nobiletin
CAS:<p>Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.</p>Formula:C21H22O8Purity:98.65% - 99.76%Color and Shape:SolidMolecular weight:402.39MRL-871
CAS:<p>MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.</p>Formula:C22H12ClF3N2O3Purity:99.66%Color and Shape:SolidMolecular weight:444.79RORγt Inverse agonist 8
CAS:<p>RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).</p>Formula:C26H33N7O2Purity:98%Color and Shape:SolidMolecular weight:475.59Methyl-3β-hydroxycholenate
CAS:<p>Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.</p>Formula:C25H40O3Purity:98.78%Color and Shape:SolidMolecular weight:388.58TF-S14
CAS:<p>TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.</p>Formula:C22H27N3O2SColor and Shape:SolidMolecular weight:397.53XY101
CAS:<p>XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).</p>Formula:C25H20F7NO4SPurity:99.83%Color and Shape:SolidMolecular weight:563.48AZD-0284
CAS:<p>AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].</p>Formula:C21H18F6N2O5SPurity:99.82%Color and Shape:SolidMolecular weight:524.43ML 209
CAS:<p>ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription</p>Formula:C25H31NO6Purity:99.87%Color and Shape:SolidMolecular weight:441.52SR2211
CAS:<p>SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).</p>Formula:C26H24F7N3OPurity:98.75%Color and Shape:SolidMolecular weight:527.483-Oxo-5β-cholanoic acid
CAS:<p>3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly</p>Formula:C24H38O3Purity:98.01% - 99.86%Color and Shape:SolidMolecular weight:374.56RORγt Inverse agonist 6
CAS:<p>RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.</p>Formula:C28H29ClN6O5Purity:99.52%Color and Shape:SolidMolecular weight:565.02FM26
CAS:<p>FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.</p>Formula:C22H15ClF3N3O3Purity:98%Color and Shape:SolidMolecular weight:461.82TMP780
CAS:<p>TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.</p>Formula:C31H30N2O4Purity:98%Color and Shape:SolidMolecular weight:494.58RORγt inverse agonist 14
CAS:<p>RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.</p>Formula:C26H26F8N2O6S2Purity:98%Color and Shape:SolidMolecular weight:678.61RORγt inverse agonist 34
CAS:<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Formula:C31H37N3O3SColor and Shape:SolidMolecular weight:531.709RORγt inhibitor 4
CAS:<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Formula:C22H16Cl2F3NO4SColor and Shape:SolidMolecular weight:518.333ROR1-IN-1
CAS:<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Formula:C33H27N5O3Molecular weight:541.60TAK-828F
CAS:<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Formula:C28H32FN3O5Purity:98%Color and Shape:SolidMolecular weight:509.57RORγt inverse agonist 32
CAS:<p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>Formula:C24H28F3NO5SColor and Shape:SolidMolecular weight:499.54Vimirogant
CAS:<p>Vimirogant is a RORγ inhibitor (Ki: <100 nM).</p>Formula:C27H35F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:552.65RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Formula:C28H32F3N5O4S2Color and Shape:SolidMolecular weight:623.71
