NAMPT
Nicotinamide Phosphoribosyltransferase (NAMPT) is an enzyme involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme in cellular metabolism and energy production. NAMPT inhibitors are of interest in cancer research due to their ability to disrupt NAD+ metabolism and induce cell death in cancer cells. These inhibitors are also explored in the context of metabolic disorders and aging. At CymitQuimica, we offer NAMPT inhibitors to support your research in cancer biology, metabolism, and aging.
Found 36 products of "NAMPT"
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SBI-797812
CAS:<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>Formula:C19H22N4O4SPurity:99.31%Color and Shape:SolidMolecular weight:402.47Nampt-IN-5
CAS:<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>Formula:C25H25N5O2Purity:99.30%Color and Shape:SolidMolecular weight:427.5Nampt activator-1
CAS:<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>Formula:C16H17N3O3Purity:99.84% - 99.98%Color and Shape:SoildMolecular weight:299.32CB 300919
CAS:<p>CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.</p>Formula:C32H34ClN7O2Color and Shape:SolidMolecular weight:584.11NAMPT degrader-3
<p>NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.</p>Formula:C56H74N8O7SPurity:98%Color and Shape:SolidMolecular weight:1003.3Nampt degrader-2
<p>Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.</p>Formula:C59H73N9O7SColor and Shape:SolidMolecular weight:1052.33NAMPT activator-7
<p>NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.</p>Formula:C21H17ClN4O3Molecular weight:408.09892Nampt-IN-10 trihydrochloride
<p>Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.</p>Formula:C27H31Cl3FN5O2Color and Shape:SolidMolecular weight:582.92LYP-8
<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>Formula:C56H74N8O10SMolecular weight:1050.52486PROTAC NAMPT Degrader-1
<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>Formula:C57H69N13O8S2Molecular weight:1127.48335ALT-100 (Human IgG1)
<p>ALT-100 (HumanIgG1) is a human-derived IgG1 monoclonal antibody that targets NAMPT. For its isotype control, please refer to HumanIgG1kappa, Isotype Control.</p>Color and Shape:Odour LiquidNAMPT Protein, Human, Recombinant (His)
<p>Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but</p>Purity:94% - 94%Color and Shape:Lyophilized PowderMolecular weight:55 KDa (reducing condition)NAT
CAS:<p>NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.</p>Formula:C18H21NO3Purity:99.65%Color and Shape:SolidMolecular weight:299.36CHS-828
CAS:<p>CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).</p>Formula:C19H22ClN5OPurity:98% - 99.9%Color and Shape:SolidMolecular weight:371.86STF-118804
CAS:<p>STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.</p>Formula:C25H23N3O4SPurity:98.66%Color and Shape:SolidMolecular weight:461.53GNE-617
CAS:<p>GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.</p>Formula:C21H15F2N3O3SPurity:99.28% - 99.71%Color and Shape:SolidMolecular weight:427.42LB-60-OF61 hydrochloride
CAS:<p>LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.</p>Formula:C29H31ClN6O2Color and Shape:SolidMolecular weight:531.06KPT9274
CAS:<p>KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.</p>Formula:C35H29F3N4O3Purity:99.75% - 99.93%Color and Shape:SolidMolecular weight:610.62GNE-617 hydrochloride
CAS:<p>GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).</p>Formula:C21H16ClF2N3O3SColor and Shape:SolidMolecular weight:463.88Nampt-IN-1
CAS:<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Formula:C20H25N3O5SPurity:99.28% - 99.4%Color and Shape:SolidMolecular weight:419.49(E)-Daporinad
CAS:<p>(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.</p>Formula:C24H29N3O2Purity:98.44% - >99.99%Color and Shape:SolidMolecular weight:391.51Nampt-IN-9
CAS:<p>Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.</p>Formula:C26H33N3O4Color and Shape:SolidMolecular weight:451.56Nampt-IN-7
CAS:<p>Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).</p>Formula:C20H21N5O3Color and Shape:SolidMolecular weight:379.41Nampt activator-3
CAS:<p>NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.</p>Formula:C19H20N2O3Color and Shape:SolidMolecular weight:324.37A-1293201
CAS:<p>A-1293201 is a potent and selective NAMPT inhibitor.</p>Formula:C21H23N3O3Color and Shape:SolidMolecular weight:365.43Teglarinad chloride
CAS:<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Formula:C30H43Cl2N5O8Purity:98.09%Color and Shape:SolidMolecular weight:672.6LB-60-OF61
CAS:<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Formula:C29H30N6O2Purity:99.47%Color and Shape:SolidMolecular weight:494.59JGB-1-155
CAS:<p>JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].</p>Formula:C26H38N2O3Color and Shape:SolidMolecular weight:426.59Nampt-IN-10 TFA
CAS:<p>Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.</p>Formula:C29H29F4N5O4Color and Shape:SolidMolecular weight:587.21557GNE-618
CAS:<p>GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).</p>Formula:C21H15F3N4O3SColor and Shape:SolidMolecular weight:460.43NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formula:C17H21N5O3SColor and Shape:SolidMolecular weight:375.45Nampt activator-4
CAS:<p>Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].</p>Formula:C26H22F3N7OSColor and Shape:SolidMolecular weight:537.56CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Formula:C26H22BrN5O2Purity:99.04%Color and Shape:SolidMolecular weight:516.39Nampt-IN-15
CAS:<p>Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.</p>Formula:C24H30N4O2Color and Shape:SolidMolecular weight:406.52Nampt-IN-13
CAS:<p>Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).</p>Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Formula:C33H35N7O2Color and Shape:SolidMolecular weight:561.68
