PPAR
Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes involved in metabolism, particularly fatty acid storage and glucose metabolism. PPAR inhibitors are important tools for studying metabolic disorders such as diabetes, obesity, and cardiovascular diseases. These inhibitors can modulate lipid metabolism, insulin sensitivity, and inflammation, making them valuable in therapeutic research. At CymitQuimica, we offer a range of PPAR inhibitors to support your research in metabolic diseases, endocrinology, and drug development.
Found 179 products for "PPAR".
Filter by
Purity percentage
0
100
|
0
|
50
|
90
|
95
|
100
- Lower prices
- Higher prices
- Lower purities
- Higher purities
- Faster estimated delivery
PPARδ agonist 9
CAS:PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atheroscleroticFormula:C26H28ClF3N4O3SPurity:98%Color and Shape:SolidMolecular weight:569.04Inolitazone
CAS:Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.Formula:C27H26N4O4SPurity:99.41% - 99.53%Color and Shape:SolidMolecular weight:502.58Ragaglitazar
CAS:Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.Formula:C25H25NO5Purity:97.46% - 98.56%Color and Shape:SolidMolecular weight:419.47SR 11023
CAS:SR 11023, an orally active PPAR γ antagonist, exhibits an IC 50 value of 109 nM and is significant in diabetes research [1].Formula:C33H36N2O3Color and Shape:SolidMolecular weight:508.65Anti-NASH agent 2
CAS:Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.
Formula:C32H51N3O2Color and Shape:SolidMolecular weight:509.766PPARγ agonist 17
CAS:PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.Formula:C48H63NO7Color and Shape:SolidMolecular weight:766.016GSK1820795A
CAS:GSK1820795A is a selective G2A/GPR132a antagonist and a telmisartan analog.Formula:C35H34N8Purity:99.78%Color and Shape:White SolidMolecular weight:566.70DS-6930
CAS:DS-6930 is a PPARγ agonist (EC50=41 nM) that lowers glucose with fewer side effects than Rosiglitazone for diabetes research.Formula:C23H21N3O4Purity:99.64%Color and Shape:SolidMolecular weight:403.43PPARγ modulator-2
CAS:PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.Formula:C26H21NO7S3SeColor and Shape:SolidMolecular weight:634.6Amezalpat
CAS:Amezalpat is an oral, potent, selective PPARα antagonist with an IC₅₀ of 58 nM and antitumor activity.Formula:C34H41N3O4Purity:99.59%Color and Shape:White SolidMolecular weight:555.71PPARγ-IN-5
CAS:PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.Formula:C22H23ClO7Color and Shape:SolidMolecular weight:434.867PPARα/δ agonist 3
CAS:PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.Formula:C23H25F3N2O4Color and Shape:SolidMolecular weight:450.451PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46Halofenate
CAS:Halofenate is an inhibitor for hypertriglyceridemia, effectively lowering serum triglyceride levels while having minimal impact on serum cholesterol. Additionally, it reduces serum uric acid and promotes uric acid excretion independent of glomerular filtration rate. Halofenate is associated with a significant increase in plasma thyroxine (T4), along with reductions in protein-bound iodine and T4. It can displace T4 from thyroid-binding proteins, which may influence thyroid function in the body.Formula:C19H17ClF3NO4Color and Shape:SolidMolecular weight:415.79SKLB102
CAS:SKLB102 exhibits high affinity for PPARγ. It has a potent ability to reduce fat deposition and protect the liver from non-alcoholic fatty liver disease (NAFLD) by regulating adipokine expression and preventing insulin resistance.Formula:C18H14N2O4Molecular weight:322.3148Fonadelpar
CAS:Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.Formula:C25H23F3N2O4SPurity:98%Color and Shape:SolidMolecular weight:504.52PPARγ phosphorylation inhibitor 1
CAS:PPARγ phosphorylation inhibitor 1, PPARγ agonist (IC50=24 nM), inhibits CDK5-mediated Ser273 phosphorylation, antidiabetic activity.Formula:C22H14Cl2N2O4Purity:99.86%Color and Shape:White SolidMolecular weight:441.26PPARγ agonist 10
CAS:PPARγ agonist 10 (compound 33g) serves as a PPARγ agonist, enhancing insulin secretion, glucose uptake, and insulin sensitivity in βTC6 cells [1].Formula:C17H14N4O3S2Color and Shape:SolidMolecular weight:386.45Aleglitazar
CAS:Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.Formula:C24H23NO5SPurity:99.03%Color and Shape:White SolidMolecular weight:437.51
