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FXR

FXR

Farnesoid X Receptor (FXR) is a nuclear receptor that plays a key role in the regulation of bile acid homeostasis, lipid metabolism, and glucose regulation. FXR is a potential therapeutic target for treating liver diseases, metabolic disorders, and cardiovascular diseases. FXR inhibitors can modulate these pathways, offering insights into disease mechanisms and therapeutic strategies. At CymitQuimica, we provide a range of FXR inhibitors to support your research in hepatology, metabolism, and drug development.

Found 67 products for "FXR".

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  • NR1H4 activator 1
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    NR1H4 activator 1

    CAS:
    NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).
    Formula:C34H53NO7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:619.85

    Ref: TM-T12251

  • FXR agonist 9
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    FXR agonist 9

    CAS:
    FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%). It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.
    Formula:C28H30N2O5
    Color and Shape:Solid
    Molecular weight:474.55

    Ref: TM-T201586

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    FXR agonist 17

    CAS:
    FXR agonist17 is an orally active, steroidal FXR agonist with EC50 values of 42.2 nM (TR-FRET) and 176.4 nM (luciferase reporter assay). It can activate TGR5 (EC50 = 2.6 μM) but does not activate hMRGPRX4. FXR agonist17 exhibits anti-inflammatory, hepatoprotective, and antifibrotic effects, improving the activity score of metabolic dysfunction-associated fatty liver disease (NAFLD) and reducing the severity of liver fibrosis. This compound is applicable for research in NAFLD, cholestatic liver diseases, and liver fibrosis.
    Formula:C29H46N2O3S
    Molecular weight:502.75

    Ref: TM-T219141

  • BAR-2227
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    BAR-2227

    CAS:
    BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.
    Formula:C24H17Cl2NO4
    Color and Shape:Solid
    Molecular weight:454.30

    Ref: TM-T200662

  • Omesdafexor
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    Omesdafexor

    CAS:
    Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.
    Formula:C34H43N3O3
    Color and Shape:Solid
    Molecular weight:541.72

    Ref: TM-T63818

  • BMS-986339
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    BMS-986339

    CAS:
    BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.
    Formula:C35H41F4N3O4
    Color and Shape:Solid
    Molecular weight:643.71

    Ref: TM-T73155

  • FXR/CES2 modulator 1
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    FXR/CES2 modulator 1

    CAS:
    Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.
    Formula:C27H21Cl2NO5
    Color and Shape:Solid
    Molecular weight:510.36

    Ref: TM-T200901