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FXR

FXR

Farnesoid X Receptor (FXR) is a nuclear receptor that plays a key role in the regulation of bile acid homeostasis, lipid metabolism, and glucose regulation. FXR is a potential therapeutic target for treating liver diseases, metabolic disorders, and cardiovascular diseases. FXR inhibitors can modulate these pathways, offering insights into disease mechanisms and therapeutic strategies. At CymitQuimica, we provide a range of FXR inhibitors to support your research in hepatology, metabolism, and drug development.

Found 67 products for "FXR".

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  • FXR agonist 11
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    FXR agonist 11

    CAS:
    FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.
    Formula:C18H16N2O5
    Color and Shape:Solid
    Molecular weight:340.33

    Ref: TM-T203206

  • Fexarine
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    Fexarine

    CAS:
    Fexarine is a potent, selective agonist of farnesoid X receptor.
    Formula:C31H31NO5
    Color and Shape:Solid
    Molecular weight:497.58

    Ref: TM-T27316

  • LY367385
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    LY367385

    CAS:
    LY367385 is a highly effective and selective mGluR1a antagonist.
    Formula:C10H11NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:209.2

    Ref: TM-T15818

  • EDP-305
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    EDP-305

    CAS:
    EDP-305 is an oral non-bile acid FXR agonist for NAFLD and fibrosis research.
    Formula:C36H58N2O5S
    Purity:97.17%
    Color and Shape:Solid
    Molecular weight:630.921

    Ref: TM-T73414

  • ST-1892
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    ST-1892

    CAS:
    ST-1892 is a soluble partial FXR agonist.
    Formula:C16H12N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:280.28

    Ref: TM-T24837

  • FXR agonist 4
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    FXR agonist 4

    FXR agonist 4: EC50 of 1.05μM, treats hyperlipidemia, steatosis, insulin resistance, inflammation in DIO mice, for NAFLD research.
    Formula:C21H28ClN3O
    Color and Shape:Solid
    Molecular weight:373.92

    Ref: TM-T72889

  • PX20606
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    PX20606

    CAS:
    PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.
    Formula:C29H22Cl3NO4
    Color and Shape:Solid
    Molecular weight:554.85

    Ref: TM-T88353

  • BMS-986318
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    BMS-986318

    CAS:
    BMS-986318: potent FXR agonist, EC50=53/350 nM, good ADME, effective in liver disease models, for nonalcoholic steatohepatitis research.
    Formula:C30H23Cl2F3N4O3
    Color and Shape:Solid
    Molecular weight:615.43

    Ref: TM-T69686

  • GSK-8062
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    GSK-8062

    CAS:
    GSK-8062 is an agonist of farnesoid X receptor (FXR).
    Formula:C30H23Cl2NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.41

    Ref: TM-T27492

  • FXR antagonist 2
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    FXR antagonist 2

    CAS:
    Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.
    Formula:C22H26Cl2N2O2
    Color and Shape:Solid
    Molecular weight:421.36

    Ref: TM-T74754

  • GSK2324
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    GSK2324

    CAS:
    GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
    Formula:C29H22Cl2N2O4
    Purity:98.09% - 99.76%
    Color and Shape:Solid
    Molecular weight:533.402

    Ref: TM-T27460

  • Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide
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    Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide

    CAS:
    Chenodeoxycholic acid 24-acyl-β-D-glucuronide (CDCA-24G), a metabolite of CDCA, is synthesized from CDCA via the action of the UDP-glucuronosyltransferase (UG UT) isoform UGT1A3.
    Formula:C30H48O10
    Color and Shape:Solid
    Molecular weight:568.7

    Ref: TM-T85006

  • Chenodeoxycholic Acid 3-Glucuronide
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    Chenodeoxycholic Acid 3-Glucuronide

    CAS:
    Chenodeoxycholic acid 3-glucuronide (CDCA-3G), a metabolite of Chenodeoxycholic acid (CDCA), is synthesized in human liver microsomes.
    Formula:C30H48O10
    Color and Shape:Solid
    Molecular weight:568.7

    Ref: TM-T84946

  • HPG1860
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    HPG1860

    CAS:
    HPG1860 is an FXR agonist for NASH, liver fibrosis, bile acid signaling, and metabolic disease research.
    Formula:C27H26Cl2N4O4S
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:573.49

    Ref: TM-T201349

  • FXR antagonist 1
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    FXR antagonist 1

    CAS:
    "Oral FXR antagonist 1 selectively blocks intestinal FXR, with IC50 of 2.1 μM, aiding in NASH research by improving liver health."
    Formula:C36H59NO5
    Color and Shape:Solid
    Molecular weight:585.86

    Ref: TM-T64144

  • Lecufexor
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    Lecufexor

    CAS:
    Lecufexor is an agonist of the farnesoid X receptor (FXR).
    Formula:C32H21Cl3N2O5
    Color and Shape:Solid
    Molecular weight:619.88

    Ref: TM-T201138

  • V023-9340
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    V023-9340

    CAS:
    V023-9340 is a powerful FXR inhibitor with an IC50 of 4.27 μM, suitable for research in NASH (nonalcoholic steatohepatitis) [1].
    Formula:C30H32N2O4
    Color and Shape:Solid
    Molecular weight:484.59

    Ref: TM-T87602

  • Danifexor
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    Danifexor

    CAS:
    Danifexor is an agonist of the farnesoid X receptor (Farnesoid X receptor).
    Formula:C29H20Cl2N2O5
    Color and Shape:Solid
    Molecular weight:547.386

    Ref: TM-T206509

  • CymitQuimica logo
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    PX20350

    CAS:
    PX20350 is an FXR agonist with EC50 values of 83 nM for mFXR and 10 nM for hFXR. It significantly induces NDRG2 mRNA expression. PX20350 effectively inhibits the growth and metastasis of liver tumor cells (SK-GI-18 cells) and exhibits antitumor activity in orthotopic xenograft mouse models.
    Formula:C28H22Cl2F3N3O4
    Molecular weight:592.4

    Ref: TM-T213091

  • FXR agonist 12
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    FXR agonist 12

    CAS:
    FXR agonist12 (Compound C7) is an orally active FXR agonist. It downregulates bile acid synthesis-related genes and upregulates bile acid transport-related genes in HepG2 cells. FXR agonist12 alleviates ANIT-induced cholestasis and reduces liver damage and fibrosis in a mouse model of NASH.
    Formula:C26H44O3
    Color and Shape:Solid
    Molecular weight:404.626

    Ref: TM-T205709