Dehydrogenase
Dehydrogenases are enzymes involved in the oxidation-reduction reactions of metabolic pathways, playing a central role in energy production and cellular respiration. These enzymes are crucial for processes such as the citric acid cycle, glycolysis, and fatty acid oxidation. Dehydrogenase inhibitors are important tools in the study of metabolic diseases, cancer, and oxidative stress. At CymitQuimica, we provide a comprehensive selection of dehydrogenase inhibitors to support your research in metabolism, cancer biology, and biochemistry.
Found 267 products of "Dehydrogenase"
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PTC299
CAS:<p>PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA</p>Formula:C25H20Cl2N2O3Purity:99.72%Color and Shape:SolidMolecular weight:467.34XEN723
CAS:<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>Formula:C21H20FN5O2SPurity:99.5%Color and Shape:SolidMolecular weight:425.48BAY-2402234
CAS:<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>Formula:C21H18ClF5N4O4Purity:98.9%Color and Shape:SolidMolecular weight:520.84IDH-305
CAS:<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>Formula:C23H22F4N6O2Purity:99.68%Color and Shape:SolidMolecular weight:490.45LDH-IN-1
CAS:<p>LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).</p>Formula:C30H26N4O4S2Purity:99.6%Color and Shape:SolidMolecular weight:570.68RS 61443
CAS:<p>RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)</p>Formula:C23H31NO7Purity:99.37% - 99.91%Color and Shape:SolidMolecular weight:433.5SCD1 inhibitor-4
CAS:<p>SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.</p>Formula:C17H16F3N5OPurity:99.71%Color and Shape:SolidMolecular weight:363.34NCT-502
CAS:<p>NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor,</p>Formula:C18H20F3N5SPurity:99.60%Color and Shape:SolidMolecular weight:395.454-Diethylaminobenzaldehyde
CAS:<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>Formula:C11H15NOPurity:99.6%Color and Shape:Brown-Black CrystalsMolecular weight:177.24Adrenosterone
CAS:<p>Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.</p>Formula:C19H24O3Purity:98.13% - 98.29%Color and Shape:SolidMolecular weight:300.39Trilostane
CAS:<p>Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.</p>Formula:C20H27NO3Purity:99.46% - >99.99%Color and Shape:Tan CrystalsMolecular weight:329.43Mycophenolic acid
CAS:<p>Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.</p>Formula:C17H20O6Purity:98.79% - 99.77%Color and Shape:SolidMolecular weight:320.34CVT-10216
CAS:<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>Formula:C24H19NO7SPurity:98.76%Color and Shape:SolidMolecular weight:465.48LY 345899
CAS:<p>LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for</p>Formula:C20H21N7O7Purity:99.7%Color and Shape:SolidMolecular weight:471.42CBR-5884
CAS:<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>Formula:C14H12N2O4S2Purity:99.97%Color and Shape:SolidMolecular weight:336.39MF-438
CAS:<p>MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).</p>Formula:C19H18F3N5OSPurity:98.98% - 99.50%Color and Shape:SolidMolecular weight:421.44GSK2837808A
CAS:<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>Formula:C31H25F2N5O7SPurity:99.78% - 99.78%Color and Shape:SolidMolecular weight:649.62ML390
CAS:<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>Formula:C21H21F3N2O3Purity:99.76%Color and Shape:SolidMolecular weight:406.4DHODH-IN-11
CAS:<p>DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.</p>Formula:C15H11N3O2Purity:98.14%Color and Shape:SolidMolecular weight:265.27Olutasidenib
CAS:<p>Olutasidenib (FT-2102), an IDH1 inhibitor (IC50: 21.2/114 nM), is studied for treating AML/MDS and can cross the blood-brain barrier.</p>Formula:C18H15ClN4O2Purity:98.57%Color and Shape:SolidMolecular weight:354.79Mutant IDH1 inhibitor
CAS:<p>Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).</p>Formula:C25H34N6O3Purity:98.3%Color and Shape:SolidMolecular weight:466.58CAY10566
CAS:<p>CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.</p>Formula:C18H17ClFN5O2Purity:99.5% - 99.54%Color and Shape:SolidMolecular weight:389.81KPLH1130
CAS:<p>KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.</p>Formula:C15H13N3O3Purity:99.07%Color and Shape:SolidMolecular weight:283.28WAY-311610
CAS:<p>WAY-311610 is an HSD11B1 inhibitor targeting 11β-HSD1 enzyme with 0.34 μM IC; used for neuropathic and inflammatory pain research.</p>Formula:C16H13F3N4O2Purity:98.01%Color and Shape:SolidMolecular weight:350.3MTHFD2-IN-3
<p>MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activity</p>Formula:C22H19NO7SColor and Shape:SolidMolecular weight:441.45LDHA-IN-3
CAS:<p>LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.</p>Formula:C13H9F3SePurity:99.71%Color and Shape:SolidMolecular weight:301.17(Rac)-BMS-816336
<p>(Rac)-BMS-816336 is a racemic 11β-HSD1 inhibitor; IC50: 10 nM (human), 68 nM (mouse), metabolically stable.</p>Formula:C21H27NO3Purity:98%Color and Shape:SolidMolecular weight:341.44PDK-IN-2
<p>PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.</p>Formula:C17H23AsCl2N2O2S2Color and Shape:SolidMolecular weight:497.33hDHODH-IN-12
<p>hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.</p>Formula:C22H15F3N4O3Purity:98%Color and Shape:SolidMolecular weight:440.37Ascochlorin A
CAS:<p>Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor</p>Formula:C23H31ClO4Color and Shape:SolidMolecular weight:406.95KOTX1
CAS:<p>KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels.</p>Formula:C17H16FN3O2Color and Shape:SolidMolecular weight:313.3311β-HSD1 inibitor 17
CAS:<p>11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).</p>Formula:C22H20F3N3O2SPurity:99.26% - 99.72%Color and Shape:SoildMolecular weight:447.47BMS-770767
CAS:<p>BMS-770767 is a novel 11-betahydroxysteroid dehydrogenase type I (11ß-HSD1) inhibitor.</p>Formula:C19H18ClN3O2Color and Shape:SolidMolecular weight:355.82Osmanthuside H
CAS:<p>Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.</p>Formula:C19H28O11Color and Shape:SolidMolecular weight:432.422IGUANA-1 free base
CAS:<p>IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.</p>Formula:C26H24ClN3O2Color and Shape:SolidMolecular weight:445.94DSM705
CAS:<p>DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.</p>Formula:C19H19F3N6OColor and Shape:SolidMolecular weight:404.397D-Lactate dehydrogenase
CAS:<p>D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.</p>Color and Shape:SolidOctanoyl Coenzyme A (sodium salt)
<p>Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.</p>Formula:C29H49N7NaO17P3SColor and Shape:SolidMolecular weight:915.71BVT-2733 hydrochloride
CAS:<p>BVT-2733 hydrochloride is a potent, selective, and orally active non-steroidal 11β-HSD1 inhibitor. It exhibits stronger inhibition on mouse 11β-HSD1 enzyme (IC50=96 nM) compared to the human 11β-HSD1 enzyme (IC50=3341 nM). BVT-2733 hydrochloride shows potential for research in arthritis and obesity-related diseases.</p>Formula:C17H22Cl2N4O3S2Color and Shape:SolidMolecular weight:465.42SCD1 inhibitor-3
CAS:<p>SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.</p>Formula:C19H16FN7O2Purity:99.5%Color and Shape:SolidMolecular weight:393.37CM121
CAS:<p>CM121, a reversible ALDH1A2 inhibitor, targets active site with IC50=0.54μM, Kd=1.1μM, using hydrophobic interactions.</p>Formula:C24H17FN4O3SColor and Shape:SolidMolecular weight:460.48Nedosiran sodium
CAS:<p>Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.</p>Color and Shape:SolidNecroptosis-IN-3
CAS:<p>Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.</p>Formula:C12H17NOSPurity:99.85%Color and Shape:SoildMolecular weight:223.33MTHFD2-IN-4
<p>MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].</p>Formula:C26H21F6N2O5Color and Shape:SolidMolecular weight:555.45MTHFD2-IN-4 sodium
<p>MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].</p>Formula:C26H21F6N2NaO5Color and Shape:SolidMolecular weight:578.44DSM1465
<p>DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.</p>Formula:C17H12ClF6N5O2Color and Shape:SolidMolecular weight:467.753MTHFD2-IN-2
<p>MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>Formula:C22H18N4O5Color and Shape:SolidMolecular weight:418.4DHODH-IN-18
CAS:<p>DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).</p>Formula:C21H16ClF5N6O4Color and Shape:SolidMolecular weight:546.842,3-Dihydroxybenzaldehyde
CAS:<p>2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.</p>Formula:C7H6O3Color and Shape:SolidMolecular weight:138.12hDHODH-IN-13
CAS:<p>hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in</p>Color and Shape:Soild
