Lipoxygenase
Lipoxygenases are a family of enzymes that catalyze the oxygenation of polyunsaturated fatty acids, leading to the production of bioactive lipid mediators such as leukotrienes and lipoxins. These mediators play critical roles in inflammation, immune responses, and cancer. Inhibitors of lipoxygenase are used to study their role in inflammatory diseases, asthma, and cancer. At CymitQuimica, we provide a variety of lipoxygenase inhibitors to support your research in inflammation, oncology, and lipid metabolism.
Found 132 products for "Lipoxygenase".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
LOX-IN-3 dihydrochloride
CAS:LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX).Formula:C13H15Cl2FN2O2SPurity:99.95% - 99.96%Color and Shape:White SolidMolecular weight:353.24Ref: TM-T39986
1mg54.00€5mg114.00€1mL*10mM (DMSO)120.00€10mg178.00€25mg334.00€50mg557.00€100mg888.00€200mg1,251.00€11-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Formula:C30H46O4Purity:99.68%Color and Shape:SolidMolecular weight:470.68Ref: TM-TN1182
1mg57.00€5mg130.00€1mL*10mM (DMSO)133.00€10mg200.00€25mg338.00€50mg497.00€100mg710.00€Phenethyl ferulate
CAS:Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).Formula:C18H18O4Purity:99.88% - 99.91%Color and Shape:White SolidMolecular weight:298.33Ref: TM-TN2330
1mg56.00€1mL*10mM (DMSO)114.00€5mg119.00€10mg192.00€25mg323.00€50mg475.00€100mg687.00€Phenidone
CAS:Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.Formula:C9H10N2OPurity:97.24%Color and Shape:White Solid Solid CrystallineMolecular weight:162.19Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formula:C16H11N3O2Purity:99.55%Color and Shape:Red SolidMolecular weight:277.28Chebulagic acid
CAS:Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Formula:C41H30O27Purity:97.82% - 99.8%Color and Shape:White SolidMolecular weight:954.66Ref: TM-TQ0180
1mg74.00€5mg157.00€10mg225.00€1mL*10mM (DMSO)244.00€25mg376.00€50mg560.00€100mg798.00€ML355
CAS:ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.Formula:C21H19N3O4S2Purity:97.17% - 98.02%Color and Shape:SolidMolecular weight:441.52Ref: TM-T4347
1mg43.00€5mg92.00€1mL*10mM (DMSO)96.00€10mg152.00€25mg281.00€50mg462.00€100mg708.00€200mg964.00€Nordihydroguaiaretic acid
CAS:Nordihydroguaiaretic acid (NDGA) is a natural lipoxygenase (5-LOX) inhibitor. Nordihydroguaiaretic acid has antioxidant effect. Cost-effective and quality-assured.Formula:C18H22O4Purity:97.82% - 99.91%Color and Shape:SolidMolecular weight:302.36β-Boswellic acid
CAS:β-Boswellic acid (Beta-boswellic acid) and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemicFormula:C30H48O3Purity:99.2% - 99.96%Color and Shape:White SolidMolecular weight:456.70Ref: TM-TN1097
1mg58.00€5mg137.00€1mL*10mM (DMSO)161.00€10mg212.00€25mg363.00€50mg527.00€100mg747.00€ML351
CAS:ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).Formula:C15H11N3OPurity:97.67%Color and Shape:SolidMolecular weight:249.27Ref: TM-T21902
1mg50.00€5mg105.00€1mL*10mM (DMSO)117.00€10mg167.00€25mg334.00€50mg505.00€100mg713.00€FPL 62064
CAS:FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandinFormula:C16H15N3OPurity:98.79%Color and Shape:SolidMolecular weight:265.31Ref: TM-T8356
2mg35.00€5mg52.00€1mL*10mM (DMSO)73.00€10mg86.00€25mg136.00€50mg198.00€100mg298.00€200mg414.00€5-O-Demethylnobiletin
CAS:5-O-Demethylnobiletin is a natural anti-inflammatory that inhibits 5-LOX without altering COX-2 expression.Formula:C20H20O8Purity:99.83% - ≥95%Color and Shape:SolidMolecular weight:388.373-Hydroxycoumarin
CAS:3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitorsFormula:C9H6O3Purity:99.5% - 99.77%Color and Shape:SolidMolecular weight:162.14Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Formula:C23H22ClNO2Purity:99.25%Color and Shape:White SolidMolecular weight:379.88Ref: TM-T6568
5mg44.00€1mL*10mM (DMSO)48.00€10mg66.00€25mg119.00€50mg177.00€100mg264.00€200mg394.00€500mg623.00€3-O-Acetyl-11-hydroxy-β-boswellic acid
CAS:3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).Formula:C32H50O5Purity:98.24%Color and Shape:SolidMolecular weight:514.74Linoleyl alcohol
CAS:Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL), fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].Formula:C18H34OPurity:98.12%Color and Shape:SolidMolecular weight:266.46Oxyberberin
CAS:Controlled ProductApplications Oxyberberin is a naturally occurring isoquinoline alkaloid shown to inhibit lipoxygenase and provide antioxidant activity.
References Misík V. et al.: Planta. Med., 61, 372 (1995)Formula:C20H17NO5Color and Shape:NeatMolecular weight:351.35a-Boswellic Acid
CAS:Controlled ProductApplications The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
References Safayhi, H. et al.: J. Pharmacol. Exp. Therap., 261, 1143 (1992); Siemoneit, U., et al.: Eur. J. Pharmacol., 606, 246 (2009); Cao, H. et al.: Pharamacol. Res., 61, 519 (2010);Formula:C30H48O3Color and Shape:NeatMolecular weight:456.7Golocdacimab
CAS:Golocdacimab (anti-LOX-1 mAb) targets LOX-1, with potential applications for type 2 diabetes complications and preventing HAE attacks.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDa1-Stearoyl-2-Oleoyl-3-Linoleoyl-rac-glycerol
CAS:1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol is a triacylglycerol consisting of stearic acid, oleic acid, and linoleic acid esterified at the sn-1, sn-2, and sn-3 positions, respectively. This compound is present in peanut and soybean oils as well as in ostrich and emu oils. Additionally, it serves as a substrate for soybean lipoxygenase in cell-free assays.Formula:C57H104O6Color and Shape:SolidMolecular weight:885.434-(2-Methylpropyl)benzenemethanol
CAS:Controlled ProductFormula:C11H16OColor and Shape:NeatMolecular weight:164.24ICI 211965
CAS:ICI 211965 is a selective and orally potent of 5-Lipoxygenase (5-LPO).Formula:C24H23NO2SPurity:98%Color and Shape:SolidMolecular weight:389.51E 3040
CAS:E 3040 is an oral dual inhibitor of 5-lipoxygenase and thromboxane synthase with anti-inflammatory activity.Formula:C16H17N3OSColor and Shape:SolidMolecular weight:299.39L 656224
CAS:L 656224 is a 5-LO inhibitor.Formula:C20H21ClO3Purity:98%Color and Shape:SolidMolecular weight:344.83Fenleuton
CAS:Fenleuton is a 5-lipoxygenase inhibitor.Formula:C17H15FN2O3Purity:98%Color and Shape:SolidMolecular weight:314.31LP117
CAS:LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).Formula:C21H23ClN4O2SPurity:98%Color and Shape:SolidMolecular weight:430.95YS-121
CAS:YS121 inhibits mPGES-1 (IC50=3.4μM) & 5-LOX (IC50=6.5μM), and lowers PGE2 in A549 cells (EC50=12μM).Formula:C20H26ClN3O2SColor and Shape:SolidMolecular weight:407.96Atreleuton
CAS:Atreleuton (ABT-761), reversible oral 5-LO inhibitor, selectively blocks leukotriene formation.Formula:C16H15FN2O2SPurity:98%Color and Shape:SolidMolecular weight:318.37LY 221068
CAS:LY 221068 is a potent antioxidant with anti-inflammatory activity.Formula:C20H30N2O2SPurity:98%Color and Shape:SolidMolecular weight:362.53AHR-5333
CAS:AHR-5333 an antiallergy agent.Formula:C30H33F2NO4Purity:98%Color and Shape:SolidMolecular weight:509.58LY 269415
CAS:LY 269415 is an anti-inflammatory agent with antioxidant properties in vitro and could be beneficial as therapeutic agents in inflammatory arthritis.Formula:C19H28N2O2SColor and Shape:SolidMolecular weight:348.5Lipoxygenin
CAS:Lipoxygenin: IC50 of 5 μM inhibits 5-LO, hedgehog, TGF-β, activin A, BMP, Wnt signaling, and boosts cardiac marker TnnT in iPSCs.Formula:C24H22N2O4Color and Shape:SolidMolecular weight:402.44Cgp 8065
CAS:Cgp 8065 is a filaricidal compound, a dithiocarbamate-derivative of amoscanate.Formula:C16H15N3O4S2Color and Shape:SolidMolecular weight:377.44HZ52
CAS:HZ52: Potent reversible 5-LO inhibitor; IC50 0.7 μM; blocks LTs in human leukocytes.Formula:C24H26ClN3O2SColor and Shape:SolidMolecular weight:456EP6
CAS:EP6 blocks 5-LO, key in the AA cascade, reducing leukotrienes to curb inflammation and allergies.Formula:C24H30N4OPurity:98%Color and Shape:SolidMolecular weight:390.52RG 6866
CAS:RG 6866 is a inhibitor of 5-lipoxygenase.Formula:C16H17NO3Purity:98%Color and Shape:SolidMolecular weight:271.31Fluindione
CAS:Fluindione is a hematologic drug.Formula:C15H9FO2Color and Shape:SolidMolecular weight:240.23BI-L 357
CAS:BI-L 357, a prodrug of BL-L 226, is a selective, orally active inhibitor of 5-lipoxygenase.Formula:C18H18O4SColor and Shape:SolidMolecular weight:330.42-TEDC
CAS:2-TEDC: Potent LOX inhibitor, blocks 5-LOX, 12-LOX, 15-LOX (IC50: 0.09, 0.013, 0.5 μM); aids atherosclerosis research.Formula:C16H13NO4SPurity:99.97%Color and Shape:SolidMolecular weight:315.34L-651392
CAS:L-651392 is an inhibitor of leukotriene.Formula:C14H10BrNO3SColor and Shape:SolidMolecular weight:352.2MLS000536924
CAS:MLS000536924 is a potent and selective competitive human epithelial 15-lipoxygenase-2 inhibitor.Formula:C16H15N3SColor and Shape:SolidMolecular weight:281.38tHGA
CAS:tHGA is a potent inhibitor of lipoxygenase.Formula:C18H24O4Purity:98%Color and Shape:SolidMolecular weight:304.38L 652343
CAS:L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro. It also inhibits the synthesis of the products of both these pathways in whole cells.Formula:C22H14F3NO2S2Color and Shape:SolidMolecular weight:445.48SB 210661
CAS:SB 210661 is a potent and selective 5-lipoxygenase inhibitor.Formula:C16H14F2N2O4Purity:98%Color and Shape:SolidMolecular weight:336.29Enazadrem
CAS:Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.Formula:C18H25N3OPurity:98%Color and Shape:SolidMolecular weight:299.41Nafazatrom
CAS:Nafazatrom: pyrazolinone lipoxygenase inhibitor, anticancer & antithrombotic, boosts PGI2, reduces arrhythmias.Formula:C16H16N2O2Color and Shape:SolidMolecular weight:268.3115(S)-HETrE
CAS:15(S)-HETrE, a 15-lipoxygenated DGLA derivative, inhibits human 5-LO with IC50 of 4.6μM; 5% as effective in RBL cells.Formula:C20H34O3Color and Shape:SolidMolecular weight:322.48AHR-5333 mandelate
CAS:AHR-5333 mandelate is an anti-allergy agent preventing anaphylaxis and skin hypersensitivity; inhibits 5-HETE, LTB4, LTC4 synthesis.Formula:C38H41F2NO7Color and Shape:SolidMolecular weight:661.7413(S)-HpOTrE(γ)
CAS:13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid.Formula:C18H30O4Color and Shape:SolidMolecular weight:310.43Leukotriene A3 methyl ester
CAS:LTA3, made from 5,8,11-eicosatrienoic acid via 5-LO, is unstable; its stable methyl ester form turns into free acid when needed.Formula:C21H34O3Color and Shape:SolidMolecular weight:334.49
