Microbiology/Virology

<p>Burnettramic acid A: Fungus-derived, fights B. subtilis, S. aureus, C. albicans, S. cerevisiae. Toxic to NS-1 cells, not to fibroblasts.</p>

<p>Antituberculosis agent-7: active against P. mirabilis (MIC 31.25μM), A. niger (MIC 62.5μM), and M. tuberculosis (MIC 3.41μM).</p>

<p>Albocycline, a macrolide antibiotic from S. bruneogriseus MCRL-0129, targets staph including resistant strains.</p>

<p>YJ182 is an NDM-1 inhibitor with an IC50 of 0.23 μM, and additionally inhibits IMP-1, VIM-2, GIM-1, and MMP-2 with respective IC50 values of 0.25, 0.61, 0.49,</p>

<p>1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.</p>

<p>5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.</p>

<p>Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides.</p>

<p>Dihydronovobiocin: a coumarin antibiotic; fights S. aureus, S. haemolyticus, and others; inhibits DNA gyrase B (IC50: 64.5 nM).</p>

<p>Diacetylcercosporin: a perylenequinone inhibiting P. falciparum, L. donovani, and various cancer cells; toxic to plants at 1.62 mM.</p>

<p>KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation.</p>

<p>Oleanolic aldehyde, an antimicrobial agent, effectively hinders the growth of oral pathogens Streptococcus mutans and Porphyromonas gingivalis, implicated in</p>

<p>Avibactam Tetrabutylammonium is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases covalent and reversible.</p>

<p>Diphyllin O-glucoside is a useful organic compound for research related to life sciences and the catalog number is T125096.</p>

<p>T3SS-IN-2 (Compound 2h) serves as an inhibitor of the type three secretion system (T3SS), with applications in bacterial infection research [1].</p>

<p>Adipic dihydrazide (ADH) is a dihydrazide a bifunctional cross-linking agent for water-in-oil emulsions and a curing agent for epoxy resins.</p>

<p>Antibacterial agent 162 trifluoromethanesulfonate (compound 7), a dual-function molecule, demonstrates potent inhibitory effects on Staphylococcus aureus,</p>

<p>Averufin is a natural product that can be used as a reference standard. The CAS number of Averufin is 14016-29-6.</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Plutavimab is a humanized IgG1-κ monoclonal antibody targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein [1] [2].</p>

<p>7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as</p>

<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>

<p>This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.</p>

<p>Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.</p>

<p>Moloney murine leukemia virus reverse transcriptase (MMLV RT) is a monomeric replicative polymerase intrinsic to the retrovirus life cycle [1].</p>

<p>Xalnesiran (sodium) is siRNA for the treatment of chronic hepatitis B ( HBV )..</p>

<p>MB-66 (MAPP-66) is a fully human IgG1 antibody targeting HSV and HIV. It is a monoclonal antibody membrane intended for vaginal application. The isotype control for MB-66 can be referred to as HumanIgG1kappa, Isotype Control.</p>

<p>(±)-Emodin bianthrone (compound 10), a naturally occurring substance, demonstrates antimalarial, antitubercular, and antifungal properties [1].</p>

<p>MTase-IN-1 (compound 26), a potent and selective inhibitor of coronavirus nsp14 N7-methyltransferases, exhibits an IC50 of 0.72 nM.</p>

<p>Gramicidin C, a naturally occurring polypeptide antibiotic, is isolated from B. brevis var. G.B.</p>

<p>Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (Compound 1), a lignan with anti-HBV activity, exhibits selectivity by targeting the HBV surface</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>MAT-POS-e194df51-1 is an orally active, non-covalent, non-peptide inhibitor of the SARS-CoV-2 main protease (M^pro) with an IC_50 of 37nM.</p>

<p>Poly(A) polymerase enzymatically adds a polyadenosine tail of 20-200 adenine bases to the 3' end of RNA, a process that involves integrating ATP as AMP.</p>

<p>LmNADK1-IN-1 (MC1) inhibits L. monocytogenes NADK1, K_i 54 nM, useful in bacterial infection research.</p>

<p>Linearmycin A, a polyene antibiotic from Streptomyces, fights S. aureus, E. coli, S. cerevisiae, C. albicans, and A. niger with low MICs.</p>

<p>SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively.</p>

<p>Melarsomine dihydrochloride, used to treat canine heartworm and other helminths, is also a research tool.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>WAY-329738 has antifungal activity and can be used to treat large fungal infections.</p>

<p>Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory</p>

<p>Antitrypanosomal agent 16 functions as a potent trypanocide, exhibiting an inhibitory concentration 50 (IC50) of 0.04μM against the T.</p>

<p>Ochratoxin C is a toxic metabolite from Aspergillus orchraceus.</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>