Beta Amyloid
Beta Amyloid inhibitors are compounds that target and prevent the formation or aggregation of beta-amyloid peptides, which are implicated in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is a hallmark of the disease, leading to neuronal dysfunction and cognitive decline. Inhibitors of beta-amyloid aggregation are being explored as potential therapeutic agents to slow or prevent the progression of Alzheimer's disease. At CymitQuimica, we provide a range of beta-amyloid inhibitors to support your research in neurodegeneration, protein aggregation, and Alzheimer's therapy.
Found 204 products of "Beta Amyloid"
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Semagacestat
CAS:<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Formula:C19H27N3O4Purity:97.1% - 99.9%Color and Shape:SolidMolecular weight:361.44Aftin-4
CAS:<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Formula:C20H28N6OPurity:98.51%Color and Shape:SolidMolecular weight:368.48LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Formula:C22H19ClN2O6SPurity:99.45%Color and Shape:SolidMolecular weight:474.91LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Formula:C15H14F2N4SPurity:99% - 99.01%Color and Shape:SolidMolecular weight:320.36Anle138b
CAS:<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Formula:C16H11BrN2O2Purity:98.88% - 99.82%Color and Shape:SolidMolecular weight:343.17MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Formula:C21H21ClF2O4SPurity:98% - 99.55%Color and Shape:SolidMolecular weight:442.9PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formula:C14H12N2OSPurity:97.02%Color and Shape:SolidMolecular weight:256.32Frentizole
CAS:<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Formula:C15H13N3O2SPurity:99.82%Color and Shape:SolidMolecular weight:299.35RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Formula:C22H20F5N3O3Purity:98.5% - 99.51%Color and Shape:SolidMolecular weight:469.4ARN2966
CAS:<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Formula:C12H12N2OPurity:99.52% - 99.86%Color and Shape:SolidMolecular weight:200.24CRANAD 2
CAS:<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Formula:C23H25BF2N2O2Purity:99.44%Color and Shape:Dark Blue To Black PowderMolecular weight:410.271,1'-Methylenedi-2-naphthol
CAS:<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Formula:C21H16O2Purity:98.91%Color and Shape:Light Pink To Light Brown Crystalline PowderMolecular weight:300.35TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Formula:C39H51I3N6O9Purity:94.58%Color and Shape:SolidMolecular weight:1128.57Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formula:C8H10NO6PPurity:97.52%Color and Shape:SolidMolecular weight:247.14PBD-150
CAS:<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Formula:C15H20N4O2SPurity:99.68%Color and Shape:SolidMolecular weight:320.41Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formula:C16H24N2O6Purity:≥95%Color and Shape:SolidMolecular weight:340.37Azeliragon HCl
CAS:<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Formula:C32H40Cl3N3O2Color and Shape:SolidMolecular weight:605.04EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Formula:C18H18ClMnN2O4Purity:98.39%Color and Shape:SolidMolecular weight:416.74JLK6
CAS:<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Formula:C10H8ClNO3Purity:96.50%Color and Shape:SolidMolecular weight:225.63Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Formula:C23H16O11Purity:99.55% - >99.99%Color and Shape:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Molecular weight:468.37PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Formula:C28H24N4O2Purity:98.8% - 99.09%Color and Shape:SolidMolecular weight:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Purity:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Formula:C22H23FN6SPurity:99.79%Color and Shape:SolidMolecular weight:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Purity:95% - 95%Color and Shape:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Purity:95% - 95%Color and Shape:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Purity:95%Color and Shape:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Formula:C3D6H3NO3SColor and Shape:SolidMolecular weight:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Formula:C13H9BrN2SPurity:98%Color and Shape:SolidMolecular weight:305.19Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Formula:C26H27N3O6Color and Shape:SolidMolecular weight:477.514-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Formula:C14H11BrN2SPurity:98%Color and Shape:SolidMolecular weight:319.22Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Formula:C19H26N6OColor and Shape:SolidMolecular weight:354.45AZ4800
CAS:<p>AZD4800 is a gamma secretase modulators.</p>Formula:C24H29N5O3Color and Shape:SolidMolecular weight:435.52THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Formula:C17H15FN2OColor and Shape:SolidMolecular weight:282.31BChE-IN-8
CAS:<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Formula:C18H12BrN7O2Color and Shape:SolidMolecular weight:438.24JNJ-40418677
CAS:<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Formula:C26H22F6O2Purity:98%Color and Shape:SolidMolecular weight:480.44Glutaminyl Cyclase Inhibitor 2
CAS:<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Formula:C19H20FN3Purity:98%Color and Shape:SolidMolecular weight:309.38Chrysamine G
CAS:<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Formula:C26H16N4Na2O6Color and Shape:SolidMolecular weight:526.416K 01-162
CAS:<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Formula:C15H14BrNColor and Shape:SolidMolecular weight:288.18YIAD-0205
CAS:<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Formula:C26H16Br2ClN3Color and Shape:SolidMolecular weight:565.69OAB-14
CAS:<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Formula:C32H46N4O2Color and Shape:SolidMolecular weight:518.73TC-E 5006
CAS:<p>γ-secretase modulator</p>Formula:C29H29F4NO2Purity:98%Color and Shape:SolidMolecular weight:499.54ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Formula:C20H14F5N3O2SColor and Shape:SolidMolecular weight:455.4Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Formula:C25H27FN2O3Color and Shape:SolidMolecular weight:422.49Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Formula:C17H12N4O3SSeColor and Shape:SolidMolecular weight:431.33Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Formula:C27H33IN2Purity:99.89%Color and Shape:SolidMolecular weight:512.47RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Formula:C28H32FN5OPurity:98%Color and Shape:SolidMolecular weight:473.58γ-Secretase modulator 12
CAS:<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Formula:C25H23N3O2Color and Shape:SolidMolecular weight:397.47Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Formula:C22H30N6OColor and Shape:SolidMolecular weight:394.51AY1511
CAS:<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Formula:C17H14O6Color and Shape:SolidMolecular weight:314.29SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Formula:C18H18N4O2Purity:98%Color and Shape:SolidMolecular weight:322.36
