Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 562 products of "Cyclooxygenase (COX) Inhibitors"
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(-)-Epicatechin
CAS:<p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>Formula:C15H14O6Purity:98.55% - 98.80%Color and Shape:SolidMolecular weight:290.27Licofelone
CAS:<p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>Formula:C23H22ClNO2Purity:99.25%Color and Shape:Yellowish SolidMolecular weight:379.88SC-236
CAS:<p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>Formula:C16H11ClF3N3O2SPurity:99.74%Color and Shape:SolidMolecular weight:401.79Chebulagic acid
CAS:<p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>Formula:C41H30O27Purity:97.82% - 99.8%Color and Shape:SolidMolecular weight:954.66(-)-Epicatechin gallate
CAS:<p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>Formula:C22H18O10Purity:99.16% - 99.93%Color and Shape:SolidMolecular weight:442.37Flurbiprofen Axetil
CAS:<p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>Formula:C19H19FO4Purity:97.58% - 98%Color and Shape:SolidMolecular weight:330.35Phenidone
CAS:<p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>Formula:C9H10N2OPurity:97.24%Color and Shape:White Solid Solid CrystallineMolecular weight:162.19Ataquimas
CAS:<p>Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.</p>Formula:C11H13N3OPurity:99.96%Color and Shape:SolidMolecular weight:203.24Neochlorogenic acid
CAS:<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Formula:C16H18O9Purity:99.12% - 99.54%Color and Shape:White PowderMolecular weight:354.31Ibuprofen Lysine
CAS:<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Formula:C19H32N2O4Purity:99.26%Color and Shape:CoaMolecular weight:352.473-TERT-BUTYL-4-HYDROXYANISOLE
CAS:<p>3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.</p>Formula:C11H16O2Purity:99.65%Color and Shape:White Solid WaxyMolecular weight:180.24Diclofenac Epolamine
CAS:<p>Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.</p>Formula:C20H24Cl2N2O3Purity:99.56%Color and Shape:SolidMolecular weight:411.32SC-560
CAS:<p>SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.</p>Formula:C17H12ClF3N2OPurity:99.97%Color and Shape:SolidMolecular weight:352.74Prim-O-glucosylcimifugin
CAS:<p>Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion of G0/G1 phase.</p>Formula:C22H28O11Purity:98.57% - 99.92%Color and Shape:SolidMolecular weight:468.45RHC 80267
CAS:<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Formula:C20H34N4O4Purity:99.54%Color and Shape:White SolidMolecular weight:394.51ETHYL CAFFEATE
CAS:<p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>Formula:C11H12O4Purity:97.79%Color and Shape:SolidMolecular weight:208.21Ufenamate
CAS:<p>Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases</p>Formula:C18H18F3NO2Purity:99.89%Color and Shape:SolidMolecular weight:337.34Veratric acid
CAS:<p>Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-</p>Formula:C9H10O4Purity:99.44%Color and Shape:SolidMolecular weight:182.17Indomethacin farnesil
CAS:<p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>Formula:C34H40ClNO4Purity:97.29%Color and Shape:SolidMolecular weight:562.14N-trans-Feruloyltyramine
CAS:<p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>Formula:C18H19NO4Purity:99.56% - >99.99%Color and Shape:SolidMolecular weight:313.35Phenethyl ferulate
CAS:<p>Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).</p>Formula:C18H18O4Purity:99.88% - 99.91%Color and Shape:SolidMolecular weight:298.33(S)-Flurbiprofen
CAS:<p>Esflurbiprofen is an inhibitor of COX-1 and COX-2.</p>Formula:C15H13FO2Purity:99.99%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:244.26Dehydrodiisoeugenol
CAS:<p>Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.</p>Formula:C20H22O4Purity:99.97%Color and Shape:SolidMolecular weight:326.39Ketorolac
CAS:<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>Formula:C15H13NO3Purity:99.68%Color and Shape:White Crystalline Or White PowderMolecular weight:255.27Xanthohumol
CAS:<p>Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-</p>Formula:C21H22O5Purity:98.19% - 99.67%Color and Shape:Orange PowderMolecular weight:354.4Loxoprofen sodium (dihydrate)
CAS:<p>Loxoprofen sodium dihydrate: Non-steroidal anti-inflammatory with analgesic, antipyretic, antitumor effects; COX-1/COX-2 inhibitor. IC50: 6.5/13.5 μM.</p>Formula:C15H21NaO5Color and Shape:SolidMolecular weight:304.318Tenidap
CAS:<p>Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.</p>Formula:C14H9ClN2O3SPurity:98.56% - 99.42%Color and Shape:SolidMolecular weight:320.75NF-κB/MAPK-IN-1
CAS:<p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>Formula:C27H27NO7Purity:97.03%Color and Shape:SolidMolecular weight:477.51Bromfenac sodium hydrate
CAS:<p>Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.</p>Formula:C15H12BrNO3H2O·NaPurity:91.85% - 99.65%Color and Shape:SolidMolecular weight:383.17Oxyphenbutazone
CAS:<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>Formula:C19H20N2O3Purity:99.41% - 99.88%Color and Shape:White To Yellowish White Crystalline Powder SolidMolecular weight:324.37Meloxicam
CAS:<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Formula:C14H13N3O4S2Purity:97.09% - 99.60%Color and Shape:Light Yellow SolidMolecular weight:351.40Fenoprofen
CAS:<p>Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.</p>Formula:C15H14O3Purity:98.4%Color and Shape:SolidMolecular weight:242.27(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Formula:C13H18O2Purity:99.51% - 99.86%Color and Shape:Colourless Crystalline SolidMolecular weight:206.28Paradol
CAS:<p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>Formula:C17H26O3Purity:98.4% - 98.98%Color and Shape:SolidMolecular weight:278.39Fontolizumab
CAS:<p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>Purity:95%Color and Shape:LiquidMolecular weight:150 (kDa)Aspirin DL-lysine
CAS:<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>Formula:C15H22N2O6Color and Shape:Crystalline SolidMolecular weight:326.35Cadonilimab
CAS:<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Purity:95% - 95%Color and Shape:LiquidImidazole Salicylate
CAS:<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>Formula:C10H10N2O3Purity:98%Color and Shape:SolidMolecular weight:206.2Indometacin Farnesil
CAS:Formula:C34H40ClNO4Purity:>98.0%(HPLC)Color and Shape:Light yellow to Yellow to Orange clear liquidMolecular weight:562.15Ketorolac-d5
CAS:<p>Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.</p>Formula:C15H8D5NO3Purity:98.99%Color and Shape:SolidMolecular weight:260.3Nepafenac-d5
CAS:<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Formula:C15H14N2O2Purity:98%Color and Shape:SolidMolecular weight:259.31AHR-10037
CAS:<p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>Formula:C15H13ClN2O2Purity:98%Color and Shape:SolidMolecular weight:288.73Amfenac
CAS:<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Formula:C15H13NO3Color and Shape:SolidMolecular weight:255.27Pelubiprofen
CAS:<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Formula:C16H18O3Purity:99.69%Color and Shape:SolidMolecular weight:258.31COX-2-IN-2
CAS:<p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>Formula:C17H12FN3O2SPurity:97.62%Color and Shape:SolidMolecular weight:341.36COX-2-IN-26
CAS:<p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>Formula:C23H21N7OS3Color and Shape:SolidMolecular weight:507.65Loxoprofenol-SRS tromethamine
CAS:<p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>Formula:C19H31NO6Color and Shape:SolidMolecular weight:369.45COX-2-IN-24
CAS:<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Formula:C24H24BrN5O3S2Color and Shape:SolidMolecular weight:574.51COX-2-IN-18
CAS:<p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>Formula:C18H19N3O3S2Color and Shape:SolidMolecular weight:389.49COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Formula:C18H18N4O6Color and Shape:SolidMolecular weight:386.364SC57666
CAS:<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Formula:C18H17FO2SPurity:98.83%Color and Shape:SolidMolecular weight:316.39FR-188582
CAS:<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Formula:C16H13ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:332.8Anti-inflammatory agent 56
CAS:<p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>Formula:C21H15F3N4O4SPurity:98%Color and Shape:SolidMolecular weight:476.43COX/5-LO-IN-1
CAS:<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Formula:C16H15FN2O2SPurity:98%Color and Shape:SolidMolecular weight:318.37MK-0703
CAS:<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Formula:C17H22O5SPurity:98%Color and Shape:SolidMolecular weight:338.42COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Formula:C21H21N7S3Color and Shape:SolidMolecular weight:467.63COX-2-IN-17
CAS:<p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>Formula:C20H23ClN6O2Color and Shape:SolidMolecular weight:414.89COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Formula:C24H25N5O3S2Color and Shape:SolidMolecular weight:495.62COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Formula:C14H8N2O8Color and Shape:SolidMolecular weight:332.22COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Formula:C15H10BrClN2OColor and Shape:SolidMolecular weight:349.61K-80001
CAS:<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Formula:C20H17FO2Color and Shape:SolidMolecular weight:308.35Anti-inflammatory agent 8
CAS:<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Formula:C18H15N5OS2Color and Shape:SolidMolecular weight:381.47Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Formula:C19H20N2O3SColor and Shape:SolidMolecular weight:356.44COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Formula:C23H18F3N5O3SColor and Shape:SolidMolecular weight:501.48Naproxen glucuronide
CAS:<p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>Formula:C20H22O9Color and Shape:SolidMolecular weight:406.38AL-8417
CAS:<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Formula:C29H34O5Purity:98%Color and Shape:SolidMolecular weight:462.58PD 127443
CAS:<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Formula:C20H28N2OColor and Shape:SolidMolecular weight:312.45COX-2-IN-32
CAS:<p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>Formula:C25H24O6Purity:98%Color and Shape:SolidMolecular weight:420.45Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Formula:C22H26N4O2SColor and Shape:SolidMolecular weight:410.53ASP-6537
CAS:<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Formula:C17H17N3O3Purity:98%Color and Shape:SolidMolecular weight:311.34COX/5-LOX-IN-1
CAS:<p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>Formula:C18H30O3Color and Shape:SolidMolecular weight:294.43Pifoxime
CAS:<p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>Formula:C15H20N2O3Color and Shape:SolidMolecular weight:276.33COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Formula:C19H12BrN3O2Color and Shape:SolidMolecular weight:394.22COX-2/5-LOX-IN-3
CAS:<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Formula:C17H16ClN3O2SColor and Shape:SolidMolecular weight:361.85ATB-337
CAS:<p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>Formula:C23H15Cl2NO2S3Color and Shape:SolidMolecular weight:504.47Flosulide
CAS:<p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>Formula:C16H13F2NO4SPurity:98%Color and Shape:SolidMolecular weight:353.34AHR-6293
CAS:<p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>Formula:C15H12ClNO3Color and Shape:SolidMolecular weight:289.71NCX 466
CAS:<p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>Formula:C20H24N2O9Purity:98%Color and Shape:SolidMolecular weight:436.41Etoricoxib HCl
CAS:<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Formula:C18H16Cl2N2O2SColor and Shape:SolidMolecular weight:395.30Lobeglitazone Sulfate
CAS:<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>Formula:C24H26N4O9S2Purity:98.69%Color and Shape:SolidMolecular weight:578.61LY 25648
CAS:<p>LY 25648 is an antagonist of leukotriene B4.</p>Formula:C19H27NO2SColor and Shape:SolidMolecular weight:333.49ZXX2-77
CAS:<p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>Formula:C13H13ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:296.77LY 150310
CAS:<p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>Formula:C13H14N2Color and Shape:SolidMolecular weight:198.26PC407-ws
CAS:<p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>Formula:C24H18F3N3Na2O5SPurity:98%Color and Shape:SolidMolecular weight:563.46Isonixin
CAS:<p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>Formula:C14H14N2O2Purity:98%Color and Shape:SolidMolecular weight:242.27Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Formula:C13H11ClN2OPurity:99.76%Color and Shape:SolidMolecular weight:246.69Tenosal
CAS:<p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>Formula:C12H8O4SPurity:98%Color and Shape:SolidMolecular weight:248.25LY 178002
CAS:<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Formula:C18H25NO2SPurity:98%Color and Shape:SolidMolecular weight:319.46L 748780
CAS:<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Formula:C19H14Cl3NO4Purity:98%Color and Shape:SolidMolecular weight:426.68Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Formula:C20H24O2Purity:98%Color and Shape:SolidMolecular weight:296.4COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Formula:C11H9ClFN3O2Color and Shape:SolidMolecular weight:269.66Feprazone
CAS:<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Formula:C20H20N2O2Purity:99.6% - 99.89%Color and Shape:SolidMolecular weight:320.39Tilmacoxib
CAS:<p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>Formula:C16H19FN2O3SPurity:98%Color and Shape:SolidMolecular weight:338.4COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Formula:C18H14ClF3N4O2SPurity:>99.99%Color and Shape:SolidMolecular weight:442.84Carpro-AM1
CAS:<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Formula:C21H18ClN3OColor and Shape:SolidMolecular weight:363.84Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Formula:C16H12F5N3O2SPurity:99.88%Color and Shape:SolidMolecular weight:405.34Insulin levels modulator
CAS:<p>Insulin level regulators can be used to treat diabetes.</p>Formula:C21H23N7OSPurity:98%Color and Shape:SolidMolecular weight:421.52SC58451
CAS:<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Formula:C20H19FO2SPurity:>99.99%Color and Shape:SolidMolecular weight:342.43COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Formula:C21H22N6O4Color and Shape:SolidMolecular weight:422.44APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Formula:C15H18O2SColor and Shape:SolidMolecular weight:262.37Safrole oxide
CAS:<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Formula:C10H10O3Purity:100%Color and Shape:SolidMolecular weight:178.18(-)-Ibuprofenamide
CAS:<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Formula:C13H19NOPurity:98%Color and Shape:SolidMolecular weight:205.3Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Formula:C24H19N3O5SColor and Shape:SolidMolecular weight:461.49GW-406381
CAS:<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Formula:C21H19N3O3SPurity:99.54%Color and Shape:SolidMolecular weight:393.46COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Formula:C18H13N3O4S2Color and Shape:SolidMolecular weight:399.44COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Formula:C18H18N4O2SColor and Shape:SolidMolecular weight:354.43Timegadine
CAS:<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Formula:C20H23N5SPurity:98%Color and Shape:SolidMolecular weight:365.5ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formula:C20H24N10O10P2S2Purity:99.83%Color and Shape:SolidMolecular weight:690.54COX-2/5-LOX-IN-1
CAS:<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Formula:C14H10ClN3O4S2Color and Shape:SolidMolecular weight:383.83Heterophdoid A
CAS:<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Formula:C26H42O10Color and Shape:SolidMolecular weight:514.61Naproxcinod
CAS:<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Formula:C18H21NO6Color and Shape:SolidMolecular weight:347.36Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Formula:C19H20FNO5Purity:99.88%Color and Shape:SolidMolecular weight:361.36COX-2-IN-28
CAS:<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Formula:C30H27N7S3Color and Shape:SolidMolecular weight:581.78COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Formula:C12H12OS3Color and Shape:SolidMolecular weight:268.42Naproxen etemesil
CAS:<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Formula:C17H20O5SPurity:98%Color and Shape:SolidMolecular weight:336.4Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Formula:C27H23ClN2O5Purity:99.93%Color and Shape:SolidMolecular weight:490.93ABT-963
CAS:<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Formula:C22H22F2N2O5SPurity:98% - 99.85%Color and Shape:SolidMolecular weight:464.48ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Formula:C27H26ClN3O5Purity:>99.99%Color and Shape:SolidMolecular weight:507.96Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Formula:C12H9Cl2NO2SPurity:98.53%Color and Shape:SolidMolecular weight:302.18Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Formula:C13H11N3O4S2Purity:99.93%Color and Shape:SolidMolecular weight:337.37LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Formula:C18H16ClNO4SPurity:98.16%Color and Shape:SolidMolecular weight:377.84SC-75416
CAS:<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Formula:C15H14ClF3O3Purity:98.67% - 98.67%Color and Shape:SolidMolecular weight:334.72BN-82451 2HCl
CAS:<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Formula:C18H28Cl2N2OSPurity:99.84% - >99.99%Color and Shape:SolidMolecular weight:391.4Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Formula:C13H9ClN2O2Purity:99.02% - 99.86%Color and Shape:SolidMolecular weight:260.68Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Formula:C20H29NO3Purity:98.84% - 99.97%Color and Shape:SolidMolecular weight:331.45L 651896
CAS:<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Formula:C18H18O3Purity:96.06% - 99.85%Color and Shape:SolidMolecular weight:282.33Prostaglandin E2 Ethanolamide
CAS:<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Formula:C22H37NO5Color and Shape:SolidMolecular weight:395.54Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Formula:C16H12ClNO3Purity:98.87%Color and Shape:SolidMolecular weight:301.72BW 755C
CAS:<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Formula:C10H10F3N3Purity:96.52%Color and Shape:SolidMolecular weight:229.2Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Formula:C19H14O2Purity:98%Color and Shape:SolidMolecular weight:274.31Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Formula:C16H13F2NO3S2Purity:>99.99%Color and Shape:SolidMolecular weight:369.41Thromboxane B3
CAS:<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Formula:C20H32O6Color and Shape:SolidMolecular weight:368.5Amtolmetin guacil
CAS:<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Formula:C24H24N2O5Purity:99.85%Color and Shape:White Needle-Shaped CrystalMolecular weight:420.46(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Formula:C20H26O4Purity:98%Color and Shape:SolidMolecular weight:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Formula:C16H13ClFN3O3SPurity:98.22%Color and Shape:SolidMolecular weight:381.81COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Formula:C31H32FN5O2SColor and Shape:SolidMolecular weight:557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Formula:C17H19NO3Color and Shape:SolidMolecular weight:285.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Formula:C19H18N2O5SColor and Shape:SolidMolecular weight:386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Formula:C19H19N3O4S2Color and Shape:SolidMolecular weight:417.5Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Formula:C18H15N5O2SColor and Shape:SolidMolecular weight:365.41Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Formula:C25H30N4O4S2Purity:99.54%Color and Shape:SolidMolecular weight:514.66NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Formula:C25H24O7Color and Shape:SolidMolecular weight:436.454Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Formula:C17H13BrN4O3S2Color and Shape:SolidMolecular weight:465.34STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Formula:C28H25ClN6O5Color and Shape:SolidMolecular weight:560.988XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Formula:C24H20N4O2SColor and Shape:SolidMolecular weight:428.51COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Formula:C20H27NO6SPurity:99.29% - 99.69%Color and Shape:SoildMolecular weight:409.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Formula:C15H10ClIN2OColor and Shape:SolidMolecular weight:396.61COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Formula:C22H23FN2O6S2Color and Shape:SolidMolecular weight:494.56(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Formula:C16H14O3Color and Shape:SolidMolecular weight:254.28Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Formula:C19H26O6Color and Shape:SolidMolecular weight:350.41COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Formula:C15H13N3O2S2Color and Shape:SolidMolecular weight:331.41Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formula:C31H50O4Color and Shape:SolidMolecular weight:486.73Neral
CAS:<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Formula:C10H16OColor and Shape:SolidMolecular weight:152.23COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Formula:C23H18F4O3SColor and Shape:SolidMolecular weight:450.446COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Formula:C25H21N3O3SColor and Shape:SolidMolecular weight:443.52COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Formula:C15H15NO3Color and Shape:SolidMolecular weight:257.28COX-2-IN-47
CAS:<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Formula:C18H18N2O4Color and Shape:SolidMolecular weight:326.35COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Formula:C16H17N5O2Color and Shape:SolidMolecular weight:311.34COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Formula:C19H14ClN5S2Color and Shape:SolidMolecular weight:411.93COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Formula:C25H23N5O4S2Color and Shape:SolidMolecular weight:521.61Racemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Formula:C14H14O3Purity:98%Color and Shape:Crystals From Acetone-Hexane White SolidMolecular weight:230.26Alminoprofen
CAS:<p>Alminoprofen: NSAID; reduces anaphylactic bronchoconstriction at 30 mg/kg intraduodenally.</p>Formula:C13H17NO2Color and Shape:SolidMolecular weight:219.28
