Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 91 products for "Proteasome".
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Gly-Pro-pNA hydrochloride
CAS:Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidaseFormula:C13H17ClN4O4Purity:99.84%Color and Shape:SolidMolecular weight:328.75RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Formula:C28H23Cl5N2O2Purity:97.7%Color and Shape:SolidMolecular weight:596.76Ref: TM-T13858
1mg54.00€5mg109.00€1mL*10mM (DMSO)142.00€10mg159.00€25mg233.00€50mg414.00€100mg608.00€Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purity:96.74% - 99.94%Color and Shape:SolidMolecular weight:685.89Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Formula:C17H27N3O7SPurity:99.2% - 99.64%Color and Shape:White CrystalMolecular weight:417.48Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formula:C18H24ClN3O7Purity:99.44% - 99.98%Color and Shape:SolidMolecular weight:429.85RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Formula:C19H13Cl4NOPurity:98.89% - 99.38%Color and Shape:Yellow SolidMolecular weight:413.12ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formula:C17H24BF3N2O4Purity:97.06%Color and Shape:SolidMolecular weight:388.19Ref: TM-T12079
1mg109.00€2mg158.00€5mg259.00€1mL*10mM (DMSO)285.00€10mg409.00€25mg677.00€50mg954.00€100mg1,288.00€200mg1,728.00€UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormula:C15H12F4N4O2Purity:98.12%Color and Shape:SolidMolecular weight:356.27Ref: TM-T13273
1mg50.00€5mg113.00€1mL*10mM (DMSO)124.00€10mg177.00€25mg334.00€50mg505.00€100mg782.00€Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38Ref: TM-T9710
1mg92.00€5mg192.00€1mL*10mM (DMSO)212.00€10mg289.00€25mg522.00€50mg732.00€100mg1,018.00€Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Color and Shape:Odour SolidRef: TM-L1100
1mgTo inquire10μL*10mM (DMSO)To inquire20μL*10mM (DMSO)To inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireLXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Formula:C27H22FN7O6Purity:99.89%Color and Shape:SolidMolecular weight:559.51Ref: TM-T39214L
1mg299.00€2mg447.00€5mg563.00€1mL*10mM (DMSO)830.00€10mg897.00€25mg1,324.00€50mg1,791.00€100mg2,412.00€Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Color and Shape:Odour SolidAcetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formula:C142H230N36O44SPurity:98%Color and Shape:SolidMolecular weight:3177.65DPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Formula:C33H27N7O3Color and Shape:SolidMolecular weight:569.613DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Color and Shape:Odour SolidAcetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formula:C144H231F3N36O46SColor and Shape:SolidMolecular weight:3291.65VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Formula:C18H32N4O5SColor and Shape:SolidMolecular weight:416.535Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SColor and Shape:SolidMolecular weight:3175.65874Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Color and Shape:Odour SolidZ-Gly-Pro-Phe-Leu-CHO
CAS:Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) ofFormula:C30H38N4O6Purity:98%Color and Shape:SolidMolecular weight:550.65Z-Leu-Leu-Tyr-COCHO
CAS:Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].Formula:C30H39N3O7Purity:98%Color and Shape:SolidMolecular weight:553.65Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Formula:C140H227N35O44SPurity:98%Color and Shape:SolidMolecular weight:3136.57Phepropeptin B
CAS:Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.Formula:C40H56N6O6Color and Shape:SolidMolecular weight:716.91Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Color and Shape:SolidMolecular weight:696.92Phepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Formula:C37H58N6O6Color and Shape:SolidMolecular weight:682.89Phepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Formula:C41H58N6O6Color and Shape:SolidMolecular weight:730.94β5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.Purity:98%Color and Shape:Odour SolidLU-002i TFA
LU-002i TFA is a subunit-selective protease inhibitor targeting β2c and β2i proteins, with an IC50 value of 220 nM for β2i.Formula:C37H53F3N4O9Molecular weight:754.37646SGLT2-IN-5
SGLT2-IN-5 (Compound 99) is an orally active SGLT2 inhibitor with IC₅₀ values of 0.8 nM for SGLT2, 23 nM for SGLT1, and 58 nM for DPP4. In diabetic rat models, SGLT2-IN-5 effectively regulates blood glucose and increases the levels of active GLP-1. It is suitable for research on type 2 diabetes.SGLT2-IN-6
SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values of 0.8 nM, 6.7 nM, and 72 nM for SGLT2, SGLT1, and DPP4, respectively. In diabetic rat models, SGLT2-IN-6 controls blood glucose levels and increases active GLP-1 levels. It is suitable for research on type 2 diabetes.Anticancer agent 233
Anticanceragent 233 (compound 5g) is a 3,5-bis(arylmethyl)-4-piperidone derivative exhibiting anticancer activity, with GI50 values of 0.25 and 0.23 μM against cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chloro substituents on the aryl ring of Anticanceragent 233 interact effectively with the catalytic site of the 20S proteasome, inhibiting its activity to deliver its anticancer effects.Bz-VGR-AMC
CAS:Bz-VGR-AMC is a substrate for the 20S proteasome (20Sproteasome), used to measure the chymotrypsin-like (β2) activity of the 20S proteasome.Formula:C30H37N7O6Molecular weight:591.67Biotin-epoxomicin
CAS:Biotin-epoxomicin is a biotin-labeled form of epoxomicin. It acts as a high-affinity probe targeting the proteasome (Proteasome) and is capable of covalently binding to various proteasome catalytic subunits, such as LMP7, Z, and MECL1.Formula:C35H60N6O8SMolecular weight:724.96Ac-RLR-AMC TFA
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA serves as a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). Upon enzymatic cleavage, AMC is released, and its fluorescence allows for the quantification of the trypsin-like activity of the 26S proteasome.Formula:C30H46N10O6·xCF3COOHBiotin-(Oaa)3-epoxomicin
CAS:Biotin-(Oaa)3-epoxomicin (Compound 13) is the biotinylated active form of Epoxomicin. It serves as a high-affinity probe targeting the proteasome. Biotin-(Oaa)3-epoxomicin can covalently bind to multiple proteasome catalytic subunits, such as LMP7, Z, and MECL1.Formula:C54H95N9O11SMolecular weight:1078.47Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Formula:C18H21N5O2Purity:98%Color and Shape:SolidMolecular weight:343.4H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Formula:C13H22F3N3O5Color and Shape:SolidMolecular weight:357.335-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurity:99.69%Color and Shape:SolidMolecular weight:160.17Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Formula:C22H30N6OSPurity:98%Color and Shape:SolidMolecular weight:434.63Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formula:C21H28BN3O5Purity:95.52% - 99.46%Color and Shape:SolidMolecular weight:413.28Ref: TM-T6027
1mg43.00€1mL*10mM (DMSO)89.00€5mg92.00€10mg133.00€25mg260.00€50mg416.00€100mg625.00€200mg868.00€MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purity:95.06%Color and Shape:SolidMolecular weight:382.45Ref: TM-T2470
1mg34.00€2mg49.00€5mg71.00€1mL*10mM (DMSO)75.00€10mg90.00€25mg128.00€50mg167.00€100mg284.00€ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purity:98% - 99.75%Color and Shape:Yellow SolidMolecular weight:566.51Oprozomib
CAS:Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.Formula:C25H32N4O7SPurity:98% - 99.87%Color and Shape:White SolidMolecular weight:532.61UAMC00039 dihydrochloride
CAS:UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.Formula:C16H26Cl3N3OPurity:99.70%Color and Shape:SolidMolecular weight:382.76(R)-MG-132
CAS:(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.Formula:C26H41N3O5Purity:99.90%Color and Shape:SolidMolecular weight:475.62Ref: TM-T12628
2mg38.00€5mg57.00€1mL*10mM (DMSO)71.00€10mg79.00€25mg120.00€50mg177.00€100mg268.00€200mg398.00€Epoxomicin
CAS:Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.Formula:C28H50N4O7Purity:98.65% - 98.86%Color and Shape:SolidMolecular weight:554.72Ref: TM-T6830
1mg118.00€5mg295.00€1mL*10mM (DMSO)355.00€10mg475.00€25mg773.00€50mg1,071.00€100mg1,423.00€500mg2,862.00€Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Formula:C40H57N5O7Purity:99.6% - 99.84%Color and Shape:White SolidMolecular weight:719.91MG-132
CAS:MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!Formula:C26H41N3O5Purity:95% - 99.99%Color and Shape:SolidMolecular weight:475.62Ref: TM-T2154
1mL*10mM (DMSO)44.00€10mg46.00€25mg84.00€50mg137.00€100mg205.00€200mg356.00€500mg447.00€MUN57694
CAS:MUN57694 is an inhibitor of 26S proteasome.Formula:C23H25N3O4Purity:99%Color and Shape:White SolidMolecular weight:407.46Ref: TM-T9090
2mg35.00€5mg52.00€1mL*10mM (DMSO)64.00€10mg86.00€25mg145.00€50mg210.00€100mg296.00€200mg414.00€
