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Proteasome

Proteasome

Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.

Found 94 products of "Proteasome"

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  • Proteasome-IN-5
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    Proteasome-IN-5

    CAS:
    <p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>
    Formula:C20H30BN5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:463.29

    Ref: TM-T81371

  • Proteasome β2c/i-IN-1
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    Proteasome β2c/i-IN-1

    CAS:
    <p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>
    Formula:C32H48N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:600.75

    Ref: TM-T81373

  • LU-002i
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    LU-002i

    CAS:
    <p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>
    Formula:C35H52N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:640.81

    Ref: TM-T81909

  • TCL1
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    TCL1

    CAS:
    <p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762

    Ref: TM-T206909

  • ZINC09518833
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    ZINC09518833

    CAS:
    <p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T200622

  • RBx-0597
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    RBx-0597

    CAS:
    <p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>
    Formula:C19H20F2N4O2
    Color and Shape:Solid
    Molecular weight:374.384

    Ref: TM-T206740

  • (2S,4R)-Teneligliptin
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    (2S,4R)-Teneligliptin

    CAS:
    <p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>
    Formula:C22H30N6OS
    Color and Shape:Solid
    Molecular weight:426.578

    Ref: TM-T206299

  • DPP-4-IN-15
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    DPP-4-IN-15

    CAS:
    <p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>
    Formula:C17H14F3N3O2S
    Color and Shape:Solid
    Molecular weight:381.372

    Ref: TM-T205036

  • Boc3Arg
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    Boc3Arg

    <p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>
    Formula:C21H39N5O7
    Color and Shape:Solid
    Molecular weight:473.56

    Ref: TM-T201495

  • Marizomib
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    Marizomib

    CAS:
    <p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>
    Formula:C15H20ClNO4
    Purity:98.03% - 99.41%
    Color and Shape:Solid
    Molecular weight:313.78

    Ref: TM-T16012

  • Immunoproteasome activator 1
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    Immunoproteasome activator 1

    CAS:
    <p>Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.</p>
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T200985

  • PB01
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    PB01

    CAS:
    <p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>
    Formula:C18H21N5O3
    Color and Shape:Solid
    Molecular weight:355.391

    Ref: TM-T204296

  • BI-1942
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    BI-1942

    CAS:
    <p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>
    Formula:C24H26N4O4
    Color and Shape:Solid
    Molecular weight:434.488

    Ref: TM-T205535

  • Davelizomib
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    Davelizomib

    CAS:
    <p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>
    Formula:C21H26BF2N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.25

    Ref: TM-T79842

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