Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
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Calpeptin
CAS:117591-20-5
Calpeptin is a potent, cell-permeable calpain inhibitor.
Formula:
C20H30N2O4
Purity:
97.06% - 98.33%
Color and Shape:
White To Off-White Powder
Molecular weight:
362.46
Ref: TM-T6432
| 2mg | 36.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 67.00 € | ||
| 25mg | 111.00 € | ||
| 50mg | 176.00 € | ||
| 100mg | 259.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Talabostat mesylate
CAS:150080-09-4
Talabostat mesylate (PT100): Oral DPP4 inhibitor, IC50 0.18 nM, targets tumor-linked proteins, boosts hematopoiesis.
Formula:
C10H23BN2O6S
Purity:
98% - 99.91%
Color and Shape:
Solid
Molecular weight:
310.18
Ref: TM-T4042
| 1mg | 54.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 153.00 € | ||
| 50mg | 370.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PI-1840
CAS:1401223-22-0
PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on …
Formula:
C22H26N4O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
394.47
Ref: TM-T6941
| 5mg | 37.00 € | ||
| 10mg | 68.00 € | ||
| 25mg | 114.00 € | ||
| 50mg | 215.00 € | ||
| 100mg | 321.00 € | ||
| 200mg | 459.00 € | ||
| 1mL*10mM (DMSO) | 37.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MLN9708
CAS:1201902-80-8
MLN2238 inhibits 20S proteasome's β5 site (Ki50=0.93 nM, IC50=3.4 nM), active form of Ixazomib Citrate …
Formula:
C20H23BCl2N2O9
Purity:
98.24% - ≥95%
Color and Shape:
Solid
Molecular weight:
517.12
Ref: TM-T2016
| 5mg | 50.00 € | ||
| 10mg | 66.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 129.00 € | ||
| 100mg | 211.00 € | ||
| 200mg | 314.00 € | ||
| 500mg | 523.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RA375
CAS:2649154-57-2
RA375 inhibits RPN13, enhances UPR, ROS, apoptosis, and is 10x more potent against cancer than …
Formula:
C30H25ClN4O7
Purity:
99.35%
Color and Shape:
Liquid
Molecular weight:
588.99
Ref: TM-T36902
| 1mg | 41.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 233.00 € | ||
| 50mg | 333.00 € | ||
| 100mg | 482.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
4'-Hydroxychalcone
CAS:2657-25-2
4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity
Formula:
C15H12O2
Purity:
99.71% - 99.86%
Color and Shape:
Yellow-Cream Powder
Molecular weight:
224.25
Ref: TM-T7917
| 5g | 358.00 € | ||
| 100mg | 56.00 € | ||
| 500mg | 103.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
ONX-0914
CAS:960374-59-8
ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the …
Formula:
C31H40N4O7
Purity:
98.35% - 99.31%
Color and Shape:
Solid
Molecular weight:
580.67
Ref: TM-T6029
| 1mg | 52.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 311.00 € | ||
| 50mg | 466.00 € | ||
| 1mL*10mM (DMSO) | 154.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Bortezomib
CAS:179324-69-7
Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.
Formula:
C19H25BN4O4
Purity:
100% - 99.97%
Color and Shape:
Yellow Solid
Molecular weight:
384.24
Ref: TM-T2399
| 5mg | 50.00 € | ||
| 10mg | 61.00 € | ||
| 25mg | 76.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 138.00 € | ||
| 200mg | 214.00 € | ||
| 500mg | 354.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TPCK
CAS:402-71-1
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
Formula:
C17H18ClNO3S
Purity:
96.77%
Color and Shape:
Powder
Molecular weight:
351.85
Ref: TM-T8350
| 10mg | 32.00 € | ||
| 25mg | 46.00 € | ||
| 50mg | 59.00 € | ||
| 100mg | 87.00 € | ||
| 200mg | 112.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Epoxomicin
CAS:134381-21-8
Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at …
Formula:
C28H50N4O7
Purity:
98.65% - 98.86%
Color and Shape:
White To Off-White Solid
Molecular weight:
554.72
Ref: TM-T6830
| 1mg | 122.00 € | ||
| 5mg | 306.00 € | ||
| 10mg | 491.00 € | ||
| 25mg | 798.00 € | ||
| 50mg | 1,112.00 € | ||
| 100mg | 1,468.00 € | ||
| 500mg | 2,965.00 € | ||
| 1mL*10mM (DMSO) | 373.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Carfilzomib
CAS:868540-17-4
Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S …
Formula:
C40H57N5O7
Purity:
99.6% - 99.84%
Color and Shape:
Solid
Molecular weight:
719.91
Ref: TM-T1795
| 5mg | 52.00 € | ||
| 10mg | 73.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 134.00 € | ||
| 100mg | 176.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MDL-28170
CAS:88191-84-8
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
Formula:
C22H26N2O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
382.45
Ref: TM-T2470
| 1mg | 35.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 132.00 € | ||
| 50mg | 173.00 € | ||
| 100mg | 293.00 € | ||
| 1mL*10mM (DMSO) | 80.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
ISOGINKGETIN
CAS:548-19-6
ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.
Formula:
C32H22O10
Purity:
98% - 99.72%
Color and Shape:
Solid
Molecular weight:
566.51
Ref: TM-T4S21320
| 5mg | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Oprozomib
CAS:935888-69-0
Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 …
Formula:
C25H32N4O7S
Purity:
98% - 99.87%
Color and Shape:
Solid
Molecular weight:
532.61
Ref: TM-T6041
| 1mg | 63.00 € | ||
| 5mg | 125.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 291.00 € | ||
| 50mg | 435.00 € | ||
| 100mg | 614.00 € | ||
| 1mL*10mM (DMSO) | 144.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Proteasome inhibitor IX
CAS:856849-35-9
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 …
Formula:
C20H21B2NO5
Purity:
98.7%
Color and Shape:
Solid
Molecular weight:
377.01
Ref: TM-T21854
| 5mg | 34.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 163.00 € | ||
| 100mg | 263.00 € | ||
| 200mg | 379.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Brensocatib
CAS:1802148-05-5
Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and …
Formula:
C23H24N4O4
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
420.46
Ref: TM-TQ0038
| 1mg | 72.00 € | ||
| 5mg | 157.00 € | ||
| 10mg | 268.00 € | ||
| 25mg | 451.00 € | ||
| 50mg | 644.00 € | ||
| 1mL*10mM (DMSO) | 168.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Anagliptin
CAS:739366-20-2
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of …
Formula:
C19H25N7O2
Purity:
100% - 100%
Color and Shape:
Solid
Molecular weight:
383.45
Ref: TM-T7133
| 1mg | 46.00 € | ||
| 5mg | 91.00 € | ||
| 10mg | 151.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 463.00 € | ||
| 100mg | 674.00 € | ||
| 500mg | 1,366.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ixazomib
CAS:1072833-77-2
Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also …
Formula:
C14H19BCl2N2O4
Purity:
98% - 98.92%
Color and Shape:
Solid
Molecular weight:
361.03
Ref: TM-T2122
| 1mg | 48.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 124.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 460.00 € | ||
| 100mg | 639.00 € | ||
| 500mg | 1,328.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Trelagliptin succinate
CAS:1029877-94-8
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for …
Formula:
C22H26FN5O6
Purity:
100% - 99.27%
Color and Shape:
Solid
Molecular weight:
475.47
Ref: TM-T2296
| 10mg | 44.00 € | ||
| 25mg | 51.00 € | ||
| 50mg | 62.00 € | ||
| 100mg | 82.00 € | ||
| 200mg | 107.00 € | ||
| 500mg | 177.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
(R)-MG-132
CAS:1211877-36-9
(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor …
Formula:
C26H41N3O5
Purity:
98.45%
Color and Shape:
Solid
Molecular weight:
475.62
Ref: TM-T12628
| 1g | 1,082.00 € | ||
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 132.00 € | ||
| 50mg | 212.00 € | ||
| 100mg | 325.00 € | ||
| 500mg | 779.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
