Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 84 products for "Proteasome".
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Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Formula:C140H227N35O44SPurity:98%Color and Shape:SolidMolecular weight:3136.57Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColor and Shape:SolidMolecular weight:909.06Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SColor and Shape:SolidMolecular weight:3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Color and Shape:Odour SolidDazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38Ref: TM-T9710
1mg92.00€5mg192.00€1mL*10mM (DMSO)212.00€10mg289.00€25mg522.00€50mg732.00€100mg1,018.00€Phepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Formula:C41H58N6O6Color and Shape:SolidMolecular weight:730.94VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Formula:C18H32N4O5SColor and Shape:SolidMolecular weight:416.535Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Color and Shape:Odour SolidRef: TM-L1100
1mgTo inquire10μL*10mM (DMSO)To inquire20μL*10mM (DMSO)To inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquirePhepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Color and Shape:SolidMolecular weight:696.92LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formula:C16H27BN4O3Color and Shape:SoildMolecular weight:334.22Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Formula:C18H21N5O2Purity:98%Color and Shape:SolidMolecular weight:343.4Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Formula:C22H30N6OSPurity:98%Color and Shape:SolidMolecular weight:434.635-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurity:99.69%Color and Shape:SolidMolecular weight:160.17H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Formula:C13H22F3N3O5Color and Shape:SolidMolecular weight:357.33ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purity:98.24% - 99.31%Color and Shape:SolidMolecular weight:580.67MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purity:95.06%Color and Shape:SolidMolecular weight:382.45Ref: TM-T2470
1mg34.00€2mg49.00€5mg71.00€1mL*10mM (DMSO)75.00€10mg90.00€25mg128.00€50mg167.00€100mg284.00€Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Formula:C4H4N2O5Purity:99.01% - 99.42%Color and Shape:SolidMolecular weight:160.09ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purity:98% - 99.75%Color and Shape:Yellow SolidMolecular weight:566.514'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFormula:C15H12O2Purity:99.86% - 99.87%Color and Shape:Yellow-Cream PowderMolecular weight:224.25PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.47
