Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 72 products for "Proteasome".
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Biotin-(Oaa)3-epoxomicin
CAS:Biotin-(Oaa)3-epoxomicin (Compound 13) is the biotinylated active form of Epoxomicin. It serves as a high-affinity probe targeting the proteasome. Biotin-(Oaa)3-epoxomicin can covalently bind to multiple proteasome catalytic subunits, such as LMP7, Z, and MECL1.Formula:C54H95N9O11SMolecular weight:1078.47Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Color and Shape:Odour SolidPhepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Formula:C37H58N6O6Color and Shape:SolidMolecular weight:682.89Ac-Nle-Pro-Nle-Asp-AMC
CAS:Ac-Nle-Pro-Nle-Asp-AMC: 26S proteasome substrate for caspase-like activity analysis.Formula:C33H45N5O9Molecular weight:655.7385Suc-Leu-Leu-Val-Tyr-AMC
CAS:Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic tetrapeptide substrate for 20S proteasome and chymotrypsin-like proteases, used in drug screening.Formula:C40H53N5O10Purity:98%Color and Shape:SolidMolecular weight:763.8763Bz-VGR-AMC
CAS:Bz-VGR-AMC is a substrate for the 20S proteasome (20Sproteasome), used to measure the chymotrypsin-like (β2) activity of the 20S proteasome.Formula:C30H37N7O6Molecular weight:591.67Anticancer agent 233
Anticanceragent 233 (compound 5g) is a 3,5-bis(arylmethyl)-4-piperidone derivative exhibiting anticancer activity, with GI50 values of 0.25 and 0.23 μM against cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chloro substituents on the aryl ring of Anticanceragent 233 interact effectively with the catalytic site of the 20S proteasome, inhibiting its activity to deliver its anticancer effects.Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38375-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurity:99.69%Color and Shape:SolidMolecular weight:160.1726(R)-MG-132
CAS:(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.Formula:C27H43N3O5Purity:99.90%Color and Shape:SolidMolecular weight:489.6474VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Formula:C19H16ClN5O6SPurity:98.99% - 99.22%Color and Shape:White SolidMolecular weight:477.878TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Formula:C39H37N3O3Purity:98.2% - 99.97%Color and Shape:White SolidMolecular weight:595.7294Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Formula:C20H23BCl2N2O9Purity:98.37% - >99.99%Color and Shape:White SolidMolecular weight:517.122MG-132
CAS:MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!Formula:C26H41N3O5Purity:95% - 99.99%Color and Shape:SolidMolecular weight:475.62Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Formula:C4H4N2O5Purity:99.01% - 99.42%Color and Shape:SolidMolecular weight:160.085Vepdegestrant
CAS:Vepdegestrant(ARV-471 ) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.Formula:C45H49N5O4Purity:97.15% - >99.99%Color and Shape:SolidMolecular weight:723.9Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Formula:C20H30N2O4Purity:97.06% - 99.46%Color and Shape:SolidMolecular weight:362.46PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.46684'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFormula:C15H12O2Purity:99.86% - 99.87%Color and Shape:SolidMolecular weight:224.2546ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purity:98.24% - 99.31%Color and Shape:SolidMolecular weight:580.6719
