Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 91 products for "Proteasome".
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Brensocatib
CAS:Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).Formula:C23H24N4O4Purity:97.55% - 98.69%Color and Shape:SolidMolecular weight:420.46Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Formula:C4H4N2O5Purity:99.01% - 99.42%Color and Shape:SolidMolecular weight:160.09VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Formula:C19H16ClN5O6SPurity:98.99% - 99.22%Color and Shape:White SolidMolecular weight:477.88TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Formula:C39H37N3O3Purity:98.2% - 99.97%Color and Shape:White SolidMolecular weight:595.734'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFormula:C15H12O2Purity:99.86% - 99.87%Color and Shape:SolidMolecular weight:224.2518α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formula:C30H46O4Purity:98.54% - 99.68%Color and Shape:SolidMolecular weight:470.68ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purity:98.24% - 99.31%Color and Shape:SolidMolecular weight:580.67Ixazomib
CAS:Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.Formula:C14H19BCl2N2O4Purity:98% - 99.77%Color and Shape:SolidMolecular weight:361.03Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:97.79% - >99.99%Color and Shape:White SolidMolecular weight:384.24Ref: TM-T2399
5mg50.00€1mL*10mM (DMSO)50.00€10mg60.00€25mg75.00€50mg92.00€100mg137.00€200mg213.00€500mg353.00€PSI
CAS:PSI is a proteasome inhibitor.Formula:C32H50N4O8Purity:97% - 98.33%Color and Shape:SolidMolecular weight:618.76KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Formula:C21H23N3O6Color and Shape:SolidMolecular weight:413.42Z-LLF-CHO
CAS:Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.Formula:C29H39N3O5Purity:98%Color and Shape:SolidMolecular weight:509.64Proteasome-IN-1
CAS:Proteasome-IN-1 is an inhibitor of proteasome.Formula:C42H35N5O3Purity:98%Color and Shape:SolidMolecular weight:657.76BC-23
CAS:BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.Formula:C21H14ClN3O4SPurity:99.99%Color and Shape:SolidMolecular weight:439.87Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Formula:C16H29N3O4Purity:98%Color and Shape:SolidMolecular weight:327.4220S Proteasome activator 1
CAS:20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Formula:C27H19ClF2N2OSPurity:99.82%Color and Shape:SolidMolecular weight:492.97Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Formula:C35H52N4O7Purity:98%Color and Shape:SolidMolecular weight:640.81Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Formula:C32H48N4O7Purity:98%Color and Shape:SolidMolecular weight:600.75Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Formula:C20H30BN5O7Purity:98%Color and Shape:SolidMolecular weight:463.29
