Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
Found 94 products of "Proteasome"
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DD1
CAS:<p>DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.</p>Formula:C16H14N2O3Purity:99.57%Color and Shape:SolidMolecular weight:282.29Tripterin
CAS:<p>Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.</p>Formula:C29H38O4Purity:98.56% - 99.8%Color and Shape:Red Crystalline PowderMolecular weight:450.61Cilastatin
CAS:<p>Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.</p>Formula:C16H26N2O5SPurity:97.76% - 99.71%Color and Shape:SolidMolecular weight:358.45Proteasome inhibitor IX
CAS:<p>Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).</p>Formula:C20H21B2NO5Purity:99.77%Color and Shape:SolidMolecular weight:377.01VR23
CAS:<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Formula:C19H16ClN5O6SPurity:98.99% - 99.22%Color and Shape:SolidMolecular weight:477.88Anagliptin
CAS:<p>Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.</p>Formula:C19H25N7O2Purity:97.59% - 99.98%Color and Shape:SolidMolecular weight:383.45Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Formula:C14H19BCl2N2O4Purity:98% - 98.92%Color and Shape:SolidMolecular weight:361.03Trelagliptin succinate
CAS:<p>Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (</p>Formula:C22H26FN5O6Purity:99.27% - 99.92%Color and Shape:SolidMolecular weight:475.47(R)-MG-132
CAS:<p>(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.</p>Formula:C26H41N3O5Purity:98.45%Color and Shape:SolidMolecular weight:475.62Delanzomib
CAS:<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Formula:C21H28BN3O5Purity:95.52% - 99.46%Color and Shape:SolidMolecular weight:413.28Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Formula:C16H15F6N5O·H3PO4·H2OPurity:99.85% - 99.98%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:523.33KZR-504
CAS:<p>KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).</p>Formula:C21H23N3O6Color and Shape:SolidMolecular weight:413.42Diprotin B
CAS:<p>Diprotin B is a dipeptidyl peptidase IV inhibitor.</p>Formula:C16H29N3O4Purity:98%Color and Shape:White Lyophilized PowderMolecular weight:327.42Gemigliptin Tartrate(911637-19-9 free base)
CAS:<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Formula:C22H25F8N5O8Purity:>99.99%Color and Shape:SolidMolecular weight:639.45BC-23
CAS:<p>BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.</p>Formula:C21H14ClN3O4SPurity:98%Color and Shape:SolidMolecular weight:439.87Z-LLF-CHO
CAS:<p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>Formula:C29H39N3O5Purity:98%Color and Shape:SolidMolecular weight:509.64Proteasome-IN-1
CAS:<p>Proteasome-IN-1 is an inhibitor of proteasome.</p>Formula:C42H35N5O3Purity:98%Color and Shape:SolidMolecular weight:657.7620S Proteasome activator 1
CAS:<p>20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.</p>Formula:C27H19ClF2N2OSPurity:99.82%Color and Shape:SolidMolecular weight:492.97Gemigliptin
CAS:<p>Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)</p>Formula:C18H19F8N5O2Purity:99.72%Color and Shape:SolidMolecular weight:489.36Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Formula:C14H20ClN3O3Purity:99.15%Color and Shape:SolidMolecular weight:313.78
