Proteasome
Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.
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VR23
CAS:1624602-30-7
VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.
Formula:
C19H16ClN5O6S
Purity:
98.99% - 99.22%
Color and Shape:
Solid
Molecular weight:
477.88
Ref: TM-T7016
| 10mg | 49.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 150.00 € | ||
| 100mg | 247.00 € | ||
| 200mg | 361.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
KZR-504
CAS:1629052-78-3
KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 …
Formula:
C21H23N3O6
Color and Shape:
Solid
Molecular weight:
413.42
Ref: TM-T15678
| 1mg | 1,073.00 € | ||
| 5mg | 2,361.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
BC-23
CAS:6298-15-3
BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study …
Formula:
C21H14ClN3O4S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
439.87
Ref: TM-T26754
| 1mg | 97.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 296.00 € | ||
| 25mg | 535.00 € | ||
| 50mg | 800.00 € | ||
| 100mg | 1,199.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
20S Proteasome activator 1
CAS:2761578-18-9
20S Proteasome activator 1: IC50-0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein …
Formula:
C27H19ClF2N2OS
Purity:
99.68%
Color and Shape:
Liquid
Molecular weight:
492.97
Ref: TM-T63321
| 5mg | 69.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 180.00 € | ||
| 50mg | 305.00 € | ||
| 100mg | 500.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
(1S,2S)-Bortezomib
CAS:1132709-14-8
(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib.
Formula:
C19H25BN4O4
Purity:
98.33%
Color and Shape:
Solid
Molecular weight:
384.24
Ref: TM-T10061
| 1mg | 63.00 € | ||
| 2mg | 95.00 € | ||
| 5mg | 166.00 € | ||
| 10mg | 278.00 € | ||
| 25mg | 445.00 € | ||
| 50mg | 604.00 € | ||
| 100mg | 811.00 € | ||
| 1mL*10mM (DMSO) | 171.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
1G244
CAS:847928-32-9
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties.
Formula:
C29H30F2N4O2
Purity:
98.23%
Color and Shape:
Solid
Molecular weight:
504.57
Ref: TM-T14005
| 5mg | 39.00 € | ||
| 10mg | 57.00 € | ||
| 25mg | 102.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 263.00 € | ||
| 500mg | To inquire |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Gemigliptin Tartrate(911637-19-9 free base)
CAS:1374639-74-3
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 …
Formula:
C22H25F8N5O8
Purity:
98%
Color and Shape:
Solid
Molecular weight:
639.45
Ref: TM-T7369L
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 253.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
K-7174 dihydrochloride
CAS:191089-60-8
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion …
Formula:
C33H50Cl2N2O6
Purity:
99.15%
Color and Shape:
Solid
Molecular weight:
641.67
Ref: TM-T11742L
| 1mg | 36.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 103.00 € | ||
| 25mg | 172.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Proteasome-IN-1
CAS:374080-21-4
Proteasome-IN-1 is an inhibitor of proteasome.
Formula:
C42H35N5O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
657.76
Ref: TM-T12561
| 25mg | 1,410.00 € | ||
| 50mg | 1,852.00 € | ||
| 100mg | 2,338.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Gemigliptin
CAS:911637-19-9
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Formula:
C18H19F8N5O2
Purity:
99.33%
Color and Shape:
Solid
Molecular weight:
489.36
Ref: TM-T7369
| 2mg | 40.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 155.00 € | ||
| 50mg | 256.00 € | ||
| 100mg | 402.00 € | ||
| 500mg | 900.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Z-LLF-CHO
CAS:133429-58-0
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a …
Formula:
C29H39N3O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
509.64
Ref: TM-T78640
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Arimoclomol
CAS:289893-25-0
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be …
Formula:
C14H20ClN3O3
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
313.78
Ref: TM-T13553
| 1mg | 183.00 € | ||
| 5mg | 410.00 € | ||
| 10mg | 606.00 € | ||
| 25mg | 926.00 € | ||
| 50mg | 1,295.00 € | ||
| 100mg | 1,745.00 € | ||
| 1mL*10mM (DMSO) | 410.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
MG-115
CAS:133407-86-0
MG-115 inhibits 20S (21 nM Ki) and 26S (35 nM Ki) proteasomes, targets chymotrypsin-like activity …
Formula:
C25H39N3O5
Purity:
97.12%
Color and Shape:
White Powder
Molecular weight:
461.59
Ref: TM-T21617
| 1mg | 52.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 168.00 € | ||
| 25mg | 307.00 € | ||
| 50mg | 456.00 € | ||
| 100mg | 666.00 € | ||
| 200mg | 922.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
UK-101
CAS:1000313-40-5
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c …
Formula:
C25H48N2O5Si
Purity:
100.00% - 99.58%
Color and Shape:
Solid
Molecular weight:
484.74
Ref: TM-T13247
| 1mg | 383.00 € | ||
| 5mg | 894.00 € | ||
| 10mg | 1,198.00 € | ||
| 25mg | 1,734.00 € | ||
| 50mg | 2,210.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Davelizomib
CAS:2409841-51-4
Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Formula:
C21H26BF2N3O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
481.25
Ref: TM-T79842
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Z-LLY-FMK
CAS:133410-84-1
Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated …
Formula:
C30H40FN3O6
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
557.65
Ref: TM-T78632
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Proteasome β2c/i-IN-1
CAS:2322333-75-3
Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits …
Formula:
C32H48N4O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
600.75
Ref: TM-T81373
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Proteasome-IN-5
CAS:1613134-34-1
Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].
Formula:
C20H30BN5O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
463.29
Ref: TM-T81371
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
LU-002i
CAS:1838705-22-8
LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an …
Formula:
C35H52N4O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
640.81
Ref: TM-T81909
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
M3258
CAS:2285330-15-4
LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases …
Formula:
C17H20BNO5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
329.16
Ref: TM-T11924
| 25mg | 829.00 € | ||
| 50mg | 1,081.00 € | ||
| 100mg | 1,733.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
