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Proteasome

Proteasome

Proteasome inhibitors are compounds that inhibit the proteasome, a large protein complex responsible for degrading unwanted or damaged proteins within the cell. Inhibition of the proteasome leads to the accumulation of proteins, which can induce cell cycle arrest and apoptosis, particularly in rapidly dividing cells like cancer cells. Proteasome inhibitors are crucial in cancer research and therapy, especially in the treatment of multiple myeloma and other hematologic malignancies. At CymitQuimica, we offer proteasome inhibitors to support your research in oncology, cell biology, and drug development.

Found 72 products for "Proteasome".

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  • Z-LLF-CHO
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    Z-LLF-CHO

    CAS:
    Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.
    Formula:C29H39N3O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:509.64

    Ref: TM-T78640

  • BC-23
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    BC-23

    CAS:
    BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.
    Formula:C21H14ClN3O4S
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:439.87

    Ref: TM-T26754

  • 20S Proteasome activator 1
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    20S Proteasome activator 1

    CAS:
    20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.
    Formula:C27H19ClF2N2OS
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:492.97

    Ref: TM-T63321

  • Arimoclomol
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    Arimoclomol

    CAS:
    Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (
    Formula:C14H20ClN3O3
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:313.78

    Ref: TM-T13553

  • LONP1-IN-2
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    LONP1-IN-2

    CAS:
    LONP1-IN-2 is a selective LONP1 inhibitor (IC50=0.187 μM, >10 μM vs 20S) for cancer research.
    Formula:C16H27BN4O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:350.22

    Ref: TM-T73191

  • Proteasome-IN-5
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    Proteasome-IN-5

    CAS:
    Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].
    Formula:C20H30BN5O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:463.29

    Ref: TM-T81371

  • Proteasome β2c/i-IN-1
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    Proteasome β2c/i-IN-1

    CAS:
    Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].
    Formula:C32H48N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:600.75

    Ref: TM-T81373

  • LU-002i
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    LU-002i

    CAS:
    LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].
    Formula:C35H52N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:640.81

    Ref: TM-T81909

  • ZINC09518833
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    ZINC09518833

    CAS:
    ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).
    Formula:C24H25N3O5
    Color and Shape:Solid
    Molecular weight:435.4724

    Ref: TM-T200622

  • TCL1
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    TCL1

    CAS:
    TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
    Formula:C19H14BrClN4O2S
    Color and Shape:Solid
    Molecular weight:477.762

    Ref: TM-T206909

  • LMP7/LMP2-IN-1
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    LMP7/LMP2-IN-1

    CAS:
    LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.
    Formula:C16H27BN4O3
    Color and Shape:Soild
    Molecular weight:334.22

    Ref: TM-T88971

  • Immunoproteasome activator 1
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    Immunoproteasome activator 1

    CAS:
    Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.
    Formula:C24H23N3O3
    Color and Shape:Solid
    Molecular weight:401.4577

    Ref: TM-T200985