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Cysteine Protease

Cysteine Protease

Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.

Found 96 products of "Cysteine Protease"

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  • Cathepsin L-IN-3
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    Cathepsin L-IN-3

    CAS:
    <p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>
    Formula:C41H49N7O4S
    Color and Shape:Solid
    Molecular weight:735.94

    Ref: TM-TP2558

  • Z-Leu-Tyr-Chloromethylketone
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    Z-Leu-Tyr-Chloromethylketone

    CAS:
    <p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>
    Formula:C24H29ClN2O5
    Color and Shape:Solid
    Molecular weight:460.95

    Ref: TM-T80103

  • Z-Arg-Arg-βNA acetate
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    Z-Arg-Arg-βNA acetate

    CAS:
    <p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>
    Formula:C32H43N9O6
    Color and Shape:Solid
    Molecular weight:649.74

    Ref: TM-TP2701

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    Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

    <p>Fluorogenic substrate for cathepsins D &amp; E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.</p>
    Color and Shape:Odour Solid

    Ref: TM-T38254

  • Gallinamide A TFA
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    Gallinamide A TFA

    CAS:
    <p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>
    Formula:C33H53F3N4O9
    Color and Shape:Solid
    Molecular weight:706.79

    Ref: TM-TN7689

  • Protease Inhibitor Library
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    Protease Inhibitor Library

    <p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1100

  • Cathepsin D and E FRET Substrate
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    Cathepsin D and E FRET Substrate

    CAS:
    <p>Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.</p>
    Formula:C85H122N22O19
    Color and Shape:Solid
    Molecular weight:1756.046

    Ref: TM-T37504

  • Hepcidin-1 (mouse)
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    Hepcidin-1 (mouse)

    CAS:
    <p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>
    Formula:C111H169N31O35S8
    Color and Shape:Solid
    Molecular weight:2754.24

    Ref: TM-T80108

  • N-CBZ-Phe-Arg-AMC
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    N-CBZ-Phe-Arg-AMC

    CAS:
    <p>Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.</p>
    Formula:C33H36N6O6
    Purity:98%
    Color and Shape:White To Off-White Powder
    Molecular weight:612.68

    Ref: TM-TP1013

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    FGA139

    <p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>
    Formula:C48H58BF2N7O5
    Color and Shape:Solid
    Molecular weight:861.45605

    Ref: TM-T207702

  • Relacatib
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    Relacatib

    CAS:
    <p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>
    Formula:C27H32N4O6S
    Color and Shape:Solid
    Molecular weight:540.64

    Ref: TM-T40463

  • Z-FG-NHO-Bz
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    Z-FG-NHO-Bz

    CAS:
    <p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>
    Formula:C26H25N3O6
    Color and Shape:Solid
    Molecular weight:475.49

    Ref: TM-T80740

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    Cathepsin C-IN-6

    <p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>
    Formula:C24H35N5O4·xC2HF3O2
    Color and Shape:Solid

    Ref: TM-T79496

  • Leupeptin
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    Leupeptin

    CAS:
    <p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>
    Formula:C20H38N6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.562

    Ref: TM-T6564L

  • N-CBZ-Phe-Arg-AMC TFA
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    N-CBZ-Phe-Arg-AMC TFA

    <p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>
    Formula:C35H37F3N6O8
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:726.7

    Ref: TM-T76010

  • VK13
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    VK13

    <p>VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.</p>
    Formula:C24H28N4O5
    Color and Shape:Solid
    Molecular weight:452.503

    Ref: TM-T205197

  • 6,6′-Dihydroxythiobinupharidine
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    6,6′-Dihydroxythiobinupharidine

    CAS:
    <p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>
    Formula:C30H42N2O4S
    Color and Shape:Solid
    Molecular weight:526.73

    Ref: TM-T79978

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    Z-L(D-Val)G-CHN2

    <p>Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.</p>
    Formula:C22H31N5O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:445.51

    Ref: TM-T78119

  • Z-Phe-Tyr(tBu)-diazomethylketone
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    Z-Phe-Tyr(tBu)-diazomethylketone

    CAS:
    <p>Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.</p>
    Formula:C31H34N4O5
    Color and Shape:Solid
    Molecular weight:542.636

    Ref: TM-T35753

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    Cathepsin K inhibitor 7

    <p>Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T89126