Protease-activated Receptor
Protease-activated Receptor (PAR) inhibitors are compounds that target and inhibit the activity of PARs, a family of G-protein-coupled receptors that are activated by proteolytic cleavage. These receptors play a role in various physiological processes, including coagulation, inflammation, and tissue repair. PAR inhibitors are valuable tools for studying the mechanisms of these processes and their involvement in diseases such as cancer, cardiovascular disorders, and chronic inflammation. At CymitQuimica, we provide PAR inhibitors to aid your research in signal transduction, immune response, and therapeutic discovery.
Found 54 products of "Protease-activated Receptor"
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FLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Formula:C31H51N9O7Color and Shape:SolidMolecular weight:661.79YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Formula:C45H67N11O10Color and Shape:SolidMolecular weight:922.08TRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Formula:C30H51N9O6Color and Shape:SolidMolecular weight:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Formula:C28H41N7O9·xC2HF3O2Color and Shape:SolidP4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Color and Shape:Odour SolidTRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Formula:C36H58F3N11O10Color and Shape:SolidMolecular weight:861.922TFLLR-NH2(TFA)
CAS:TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)Formula:C33H54F3N9O8Purity:98%Color and Shape:SolidMolecular weight:761.83SLIGRL-NH2
CAS:SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.Formula:C29H56N10O7Purity:98.29%Color and Shape:SolidMolecular weight:656.82AZ3451
CAS:AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).Formula:C30H27BrN4O3Purity:98.12%Color and Shape:SolidMolecular weight:571.46PAR-2-IN-1
CAS:PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
Formula:C12H14ClN3O2Purity:99.75%Color and Shape:SolidMolecular weight:267.71Vorapaxar
CAS:Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).Formula:C29H33FN2O4Purity:98.77% - 99.93%Color and Shape:SolidMolecular weight:492.58Ref: TM-T7013
1mg71.00€5mg138.00€10mg192.00€25mg326.00€50mg447.00€100mg642.00€200mg888.00€1mL*10mM (DMSO)152.00€Vorapaxar sulfate
CAS:Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.Formula:C29H35FN2O8SPurity:99.9% - >99.99%Color and Shape:SolidMolecular weight:590.66Ref: TM-T3098
1mg38.00€2mg49.00€5mg79.00€10mg119.00€25mg210.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)99.00€TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).Formula:C35H55F6N9O10Purity:99.56%Color and Shape:SolidMolecular weight:875.87I-191
CAS:I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.Formula:C23H26FN5O2Purity:99.8%Color and Shape:SolidMolecular weight:423.48TRAP-6
CAS:TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).Formula:C34H56N10O9Purity:>99.99%Color and Shape:SolidMolecular weight:748.87Ref: TM-T7625
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg274.00€50mg411.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)126.00€PAR-4 Agonist Peptide, amide TFA
CAS:PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.Formula:C36H49F3N8O9Purity:99.72%Color and Shape:SolidMolecular weight:794.82Ref: TM-TP1065
1mg34.00€5mg92.00€10mg138.00€25mg225.00€50mg323.00€100mg467.00€200mg643.00€1mL*10mM (DMSO)131.00€Protease-Activated Receptor-1, PAR-1 Agonist acetate
PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.Formula:C37H62N10O11Purity:98.1800%Color and Shape:SolidMolecular weight:822.95PAR-2 Activating Peptide acetate
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).Formula:C31H60N10O9Purity:98.5% - 99.92%Color and Shape:SolidMolecular weight:716.88AC-55541
CAS:AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.
Formula:C25H20BrN5O3Purity:98% - 99.33%Color and Shape:SolidMolecular weight:518.36LRGILS-NH2 acetate
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.Formula:C29H56N10O7Purity:96.65%Color and Shape:SolidMolecular weight:656.82
