Glutaminase
Glutaminase inhibitors are compounds that inhibit glutaminase, an enzyme that catalyzes the conversion of glutamine to glutamate, a critical step in cellular metabolism, especially in cancer cells. Glutaminase plays a key role in providing energy and biosynthetic precursors for rapidly proliferating cells. Inhibitors of glutaminase are important for exploring metabolic dependencies in cancer cells and developing potential therapeutic strategies. At CymitQuimica, we provide glutaminase inhibitors to support your research in cancer metabolism, cellular bioenergetics, and therapeutic discovery.
Found 45 products of "Glutaminase"
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BJJF078
CAS:BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Formula:C27H29N3O6SPurity:99.56%Color and Shape:SoildMolecular weight:523.6LDN-27219
CAS:LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Formula:C20H16N4O2S2Purity:99.01% - 99.38%Color and Shape:SolidMolecular weight:408.5Ref: TM-T11831
1mg34.00€5mg63.00€1mL*10mM (DMSO)67.00€10mg96.00€25mg152.00€50mg221.00€100mg334.00€200mg489.00€L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formula:C5H12N2O3SPurity:99.56% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:180.23PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Formula:C47H57N9O6SPurity:98%Color and Shape:SolidMolecular weight:876.086-Diazo-5-oxo-L-nor-Leucine
CAS:6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Formula:C6H9N3O3Purity:98.04% - 98.93%Color and Shape:SolidMolecular weight:171.15Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formula:C4H10AsNO4Molecular weight:210.98258PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Formula:C55H73N9O10SPurity:98%Color and Shape:SolidMolecular weight:1052.29GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFormula:C20H17F3N4O3S2Purity:98%Color and Shape:SolidMolecular weight:482.5Glutaminase C-IN-2
Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.Formula:C24H23N7O2SPurity:98%Color and Shape:SolidMolecular weight:473.55LM11
LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.Formula:C26H18Cl2N4O5Molecular weight:536.06543Glutaminase-IN-1
CAS:Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Formula:C26H24F3N7O3SePurity:98.65% - 98.65%Color and Shape:SolidMolecular weight:618.47Glutaminase-IN-3
CAS:Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.Formula:C19H19F3N6O2SPurity:98.51%Color and Shape:SolidMolecular weight:452.45Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formula:C26H24F3N7O3SPurity:97.57% - 99.89%Color and Shape:SolidMolecular weight:571.57Glutaminase C-IN-1
CAS:Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Formula:C27H27BrN2OPurity:99.68% - >99.99%Color and Shape:SolidMolecular weight:475.42Ref: TM-T3964
2mg39.00€5mg57.00€1mL*10mM (DMSO)64.00€10mg93.00€25mg154.00€50mg259.00€100mg358.00€200mg528.00€L-Albizziin
CAS:L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Formula:C4H9N3O3Purity:99.98%Color and Shape:White PowderMolecular weight:147.13GK921
CAS:GK921 is a transglutaminase 2 (TGase) inhibitor.Formula:C21H20N4OPurity:97.44% - 99.92%Color and Shape:SolidMolecular weight:344.41BPTES
CAS:BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.Formula:C24H24N6O2S3Purity:95.83% - 99.64%Color and Shape:SolidMolecular weight:524.68Ref: TM-T6791
1mg34.00€2mg49.00€5mg65.00€10mg84.00€1mL*10mM (DMSO)84.00€25mg142.00€50mg207.00€100mg308.00€200mg447.00€500mg732.00€Zampilimab
CAS:Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDaIrbesartan-d4
CAS:Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Formula:C25H28N6OPurity:>99.99%Color and Shape:SolidMolecular weight:432.55ZM39923
CAS:ZM39923 is an effective JAK3 inhibitor (IC50=79 nM), simultaneously inhibiting TGM2 and Factor XIIIa (IC50=10/25 nM).Formula:C23H25NOPurity:98%Color and Shape:SolidMolecular weight:331.45
