Glutaminase
Glutaminase inhibitors are compounds that inhibit glutaminase, an enzyme that catalyzes the conversion of glutamine to glutamate, a critical step in cellular metabolism, especially in cancer cells. Glutaminase plays a key role in providing energy and biosynthetic precursors for rapidly proliferating cells. Inhibitors of glutaminase are important for exploring metabolic dependencies in cancer cells and developing potential therapeutic strategies. At CymitQuimica, we provide glutaminase inhibitors to support your research in cancer metabolism, cellular bioenergetics, and therapeutic discovery.
Found 40 products of "Glutaminase"
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BJJF078
CAS:<p>BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.</p>Formula:C27H29N3O6SPurity:98.19%Color and Shape:SoildMolecular weight:523.6LDN-27219
CAS:<p>LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.</p>Formula:C20H16N4O2S2Purity:99.01% - 99.38%Color and Shape:SolidMolecular weight:408.5Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Formula:C24H23N7O2SPurity:98%Color and Shape:SolidMolecular weight:473.55L-Methionine-DL-sulfoximine
CAS:<p>MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.</p>Formula:C5H12N2O3SPurity:99.56% - ≥98%Color and Shape:White Crystalline PowderMolecular weight:180.23PROTAC TG2 degrader-1
<p>PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.</p>Formula:C55H73N9O10SPurity:98%Color and Shape:SolidMolecular weight:1052.29PROTAC TG2 degrader-2
<p>PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.</p>Formula:C47H57N9O6SPurity:98%Color and Shape:SolidMolecular weight:876.08LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Formula:C26H18Cl2N4O5Molecular weight:536.06543Trivalent hydroxyarsinothricn
<p>Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.</p>Formula:C4H10AsNO4Molecular weight:210.982586-Diazo-5-oxo-L-nor-Leucine
CAS:<p>6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).</p>Formula:C6H9N3O3Purity:98.04% - 98.93%Color and Shape:SolidMolecular weight:171.15GLS1 Inhibitor-7
<p>GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and</p>Formula:C20H17F3N4O3S2Purity:98%Color and Shape:SolidMolecular weight:482.5Glutaminase-IN-1
CAS:<p>Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.</p>Formula:C26H24F3N7O3SePurity:98.65% - 98.65%Color and Shape:SolidMolecular weight:618.47Glutaminase-IN-3
CAS:<p>Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.</p>Formula:C19H19F3N6O2SPurity:98.51%Color and Shape:SolidMolecular weight:452.45Glutaminase C-IN-1
CAS:<p>Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.</p>Formula:C27H27BrN2OPurity:99.68% - >99.99%Color and Shape:SolidMolecular weight:475.42GK921
CAS:<p>GK921 is a transglutaminase 2 (TGase) inhibitor.</p>Formula:C21H20N4OPurity:97.44% - 99.49%Color and Shape:SolidMolecular weight:344.41BPTES
CAS:<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>Formula:C24H24N6O2S3Purity:95.83% - 99.64%Color and Shape:SolidMolecular weight:524.68Telaglenastat
CAS:<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>Formula:C26H24F3N7O3SPurity:97.57% - 99.89%Color and Shape:SolidMolecular weight:571.57L-Albizziin
CAS:<p>L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.</p>Formula:C4H9N3O3Purity:99.98%Color and Shape:White PowderMolecular weight:147.13Zampilimab
CAS:<p>Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.</p>Purity:95%Color and Shape:LiquidIrbesartan-d4
CAS:<p>Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.</p>Formula:C25H28N6OPurity:>99.99%Color and Shape:SolidMolecular weight:432.55VA4 TG2 inhibitor
CAS:<p>VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.</p>Formula:C33H41N5O6SColor and Shape:SolidMolecular weight:635.77GLS1 Inhibitor-3
CAS:<p>GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.</p>Formula:C30H32N10O2SColor and Shape:SolidMolecular weight:596.71α-Glucosidase-IN-5
CAS:<p>α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.</p>Formula:C15H13NO3Color and Shape:SolidMolecular weight:255.27Glutaminase-IN-4
CAS:<p>Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).</p>Formula:C23H22N6O2S2Color and Shape:SolidMolecular weight:478.59AA10 TG2 inhibitor
CAS:<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Formula:C32H36N4O5Color and Shape:SolidMolecular weight:556.65Duazomycin
CAS:<p>Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.</p>Formula:C8H11N3O4Color and Shape:SolidMolecular weight:213.19AA9 TG2 inhibitor
CAS:<p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>Formula:C32H36N4O5Color and Shape:SolidMolecular weight:556.65JHU-083
CAS:<p>JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.</p>Formula:C14H24N4O4Purity:97.89% - 99.53%Color and Shape:SolidMolecular weight:312.37GLS1 Inhibitor
CAS:<p>GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.</p>Formula:C19H21N7O2SColor and Shape:SolidMolecular weight:411.48NC9 TG2 inhibitor
CAS:<p>NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).</p>Formula:C35H47N5O8SPurity:98%Color and Shape:SolidMolecular weight:697.84IPN60090
CAS:<p>IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.</p>Formula:C24H27F3N8O3Purity:99.76%Color and Shape:SolidMolecular weight:532.52UPGL00004
CAS:<p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>Formula:C25H26N8O2S2Purity:97.93%Color and Shape:SolidMolecular weight:534.66Sirpiglenastat
CAS:<p>Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.</p>Formula:C22H27N5O5Purity:98.01% - 98.37%Color and Shape:SolidMolecular weight:441.48TG2-IN-3h
CAS:<p>TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor</p>Formula:C21H26N4O4SPurity:99.34% - 99.76%Color and Shape:SolidMolecular weight:430.52TG-2-IN-1
CAS:<p>TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].</p>Formula:C8H13ClN2OSPurity:98.43%Color and Shape:SolidMolecular weight:220.72KCC009
CAS:<p>KCC009 is a potent and selective Transglutaminase 2 Inhibitor.</p>Formula:C21H22BrN3O5Color and Shape:SolidMolecular weight:476.32ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Formula:C26H36N6O6Purity:99.04%Color and Shape:SolidMolecular weight:528.6TG-2-IN-4
CAS:<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Formula:C34H40N6O5Color and Shape:SolidMolecular weight:612.72TGase2-IN-1
CAS:<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Formula:C23H25N3O3Color and Shape:SolidMolecular weight:391.46GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formula:C26H25FN4OSColor and Shape:SolidMolecular weight:460.57IPN60090 dihydrochloride
CAS:<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Formula:C24H29Cl2F3N8O3Color and Shape:SolidMolecular weight:605.44
