Stem Cells
Stem cell inhibitors are compounds that specifically target stem cells and their signaling pathways, affecting their ability to self-renew and differentiate. These inhibitors are crucial in research focused on controlling stem cell behavior, understanding developmental processes, and developing therapies for diseases like cancer, where stem cells are thought to play a key role. At CymitQuimica, we offer a variety of stem cell inhibitors to support your research in regenerative medicine, developmental biology, and oncology.
Found 145 products for "Stem Cells".
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CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formula:C30H33N3Purity:99.51%Color and Shape:SolidMolecular weight:435.6031(Rac)-SIS3 free base
CAS:(Rac)-SIS3 free base blocks Smad3 signaling, lowering ADAMTS-5 and raising miRNA-140 in chondrocytes, suppressing TGF-β1–Smad3–driven podocyte EMT, and reducing activin A–induced MHSteC proliferatFormula:C28H27N3O3Purity:98%Color and Shape:SolidMolecular weight:453.5323LY2382770
LY2382770 is a human monoclonal antibody (mAb) that specifically targets TGFB1. It is utilized in the study of diabetic nephropathy.SAR-439459
SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. It blocks TGFβ-mediated pSMAD signaling and inhibits T cell and NK cell activity. Additionally, SAR-439459 exhibits antitumor properties.PF-06952229
CAS:PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.Formula:C23H24ClFN4O3Purity:99.73% - 99.73%Color and Shape:SolidMolecular weight:458.913LM-41
CAS:LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Formula:C19H14FNO2Purity:99.97%Color and Shape:SolidMolecular weight:307.32IHMT-MST1-58
CAS:IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formula:C21H22N6O3SPurity:98.31% - 99.92%Color and Shape:SolidMolecular weight:438.503LEQ506
CAS:LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formula:C25H32N6OPurity:99.76%Color and Shape:White SolidMolecular weight:432.5612SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.Formula:C14H14ClFN2O2Purity:99.94%Color and Shape:White SolidMolecular weight:296.725TT-10
CAS:TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.Formula:C11H10FN3OS2Purity:99.76%Color and Shape:SolidMolecular weight:283.345MSC-4106
CAS:MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.Formula:C18H12F3N3O2Purity:99.89%Color and Shape:SolidMolecular weight:359.302Myristoyl tetrapeptide-12
CAS:Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formula:C32H63N7O5Purity:98%Color and Shape:SolidMolecular weight:625.8865TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Formula:C25H24ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:470.923,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purity:98%Color and Shape:SolidMolecular weight:282.29TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formula:C14H10N4S2Purity:97.26%Color and Shape:SolidMolecular weight:298.386DT-6
CAS:DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showingFormula:C89H130N20O29S2Purity:98%Color and Shape:SolidMolecular weight:2008.23MR24
CAS:MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Formula:C26H29ClN6O3Molecular weight:509.00SWTX-143
CAS:SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormula:C19H18F3N3OPurity:98%Color and Shape:SolidMolecular weight:361.36M4K2308
CAS:M4K2308, a selective ALK2 ether-linked inhibitor, demonstrates an IC50 of 2 nM and exhibits greater specificity for ALK2 over ALK5, with an IC50 of 224 nM for ALK5. This compound holds potential for research into Diffuse Intrinsic Pontine Glioma (DIPG).Formula:C26H29N3O4Molecular weight:447.53
