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Stem Cells

Stem Cells

Stem cell inhibitors are compounds that specifically target stem cells and their signaling pathways, affecting their ability to self-renew and differentiate. These inhibitors are crucial in research focused on controlling stem cell behavior, understanding developmental processes, and developing therapies for diseases like cancer, where stem cells are thought to play a key role. At CymitQuimica, we offer a variety of stem cell inhibitors to support your research in regenerative medicine, developmental biology, and oncology.

Found 145 products for "Stem Cells".

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    LATS-IN-2

    CAS:
    LATS-IN-2 is a potent inhibitor of LATS, demonstrating significant inhibitory activity against LATS1 with an IC50 value of 1.3 nM. By inhibiting LATS kinase activity, LATS-IN-2 reduces the phosphorylation of YAP. Additionally, LATS-IN-2 increases the thickness of mouse epidermis and can be used in research on ocular diseases, such as limbal stem cell deficiency and corneal endothelial dysfunction.
    Formula:C15H16N6
    Molecular weight:280.34

    Ref: TM-T213611

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    VS3

    CAS:
    VS3 is an inhibitor of the YAP-TEAD interaction. By directly binding to the TEAD4 Interface 3 (Kd = 6 μM), VS3 disrupts the interaction between YAP and TEAD. It exhibits antiproliferative activity against HT29, HCT116, and A2780 cells. VS3 is useful for studying colorectal adenocarcinoma and ovarian cancer.
    Formula:C21H21N3O3
    Molecular weight:363.42

    Ref: TM-T214392

  • M3686
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    M3686

    CAS:
    M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.
    Formula:C21H18F3N5O2
    Color and Shape:Solid
    Molecular weight:429.395

    Ref: TM-T205477

  • TGFβ1-IN-1
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    TGFβ1-IN-1

    CAS:
    TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.
    Formula:C22H24N2O3
    Purity:99.89% - 99.89%
    Color and Shape:White Solid
    Molecular weight:364.438

    Ref: TM-T61389

  • TGFβRI-IN-3
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    TGFβRI-IN-3

    CAS:
    TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4.
    Formula:C28H23N3O2S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:465.566

    Ref: TM-T9523