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Porcupine

Porcupine

Porcupine inhibitors are compounds that block the activity of Porcupine, an enzyme that is essential for the secretion and activity of Wnt proteins, which are key regulators of the Wnt signaling pathway. The Wnt pathway is involved in various developmental processes, including stem cell maintenance and differentiation. Inhibiting Porcupine is a strategic approach in cancer research, as it can disrupt Wnt-driven tumorigenesis. At CymitQuimica, we provide Porcupine inhibitors to aid your research in stem cell biology, developmental biology, and cancer therapy.

Found 9 products of "Porcupine"

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  • ETC-159
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    ETC-159

    CAS:
    <p>ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.</p>
    Formula:C19H17N7O3
    Purity:96.87% - 99.30%
    Color and Shape:Solid
    Molecular weight:391.38

    Ref: TM-T4043

  • IWP L6
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    IWP L6

    CAS:
    <p>IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).</p>
    Formula:C25H20N4O2S2
    Purity:99.51% - >99.99%
    Color and Shape:Solid
    Molecular weight:472.58

    Ref: TM-T2683

  • Wnt-C59
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    Wnt-C59

    CAS:
    <p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>
    Formula:C25H21N3O
    Purity:99.56% - 99.95%
    Color and Shape:Solid
    Molecular weight:379.45

    Ref: TM-T2242

  • Porcn-IN-1
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    Porcn-IN-1

    CAS:
    <p>Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).</p>
    Formula:C25H19FN4O
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:410.44

    Ref: TM-T4438

  • IWP-O1
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    IWP-O1

    CAS:
    <p>IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.</p>
    Formula:C26H20N6O
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:432.48

    Ref: TM-T5342

  • LGK974
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    LGK974

    CAS:
    <p>LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.</p>
    Formula:C23H20N6O
    Purity:98.8% - >99.99%
    Color and Shape:Solid
    Molecular weight:396.44

    Ref: TM-T2618

  • IWP-2
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    IWP-2

    CAS:
    <p>IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.</p>
    Formula:C22H18N4O2S3
    Purity:96.1% - 99.49%
    Color and Shape:Solid
    Molecular weight:466.6

    Ref: TM-T2702

  • GNF-6231
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    GNF-6231

    CAS:
    <p>GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.</p>
    Formula:C24H25FN6O2
    Purity:99.74% - >99.99%
    Color and Shape:Solid
    Molecular weight:448.49

    Ref: TM-T11444

  • WHN-88
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    WHN-88

    CAS:
    <p>WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.</p>
    Formula:C18H13I2N3O2
    Color and Shape:Solid
    Molecular weight:557.12

    Ref: TM-T89881

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