Porcupine
Porcupine inhibitors are compounds that block the activity of Porcupine, an enzyme that is essential for the secretion and activity of Wnt proteins, which are key regulators of the Wnt signaling pathway. The Wnt pathway is involved in various developmental processes, including stem cell maintenance and differentiation. Inhibiting Porcupine is a strategic approach in cancer research, as it can disrupt Wnt-driven tumorigenesis. At CymitQuimica, we provide Porcupine inhibitors to aid your research in stem cell biology, developmental biology, and cancer therapy.
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ETC-159
CAS:1638250-96-0
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with …
Formula:
C19H17N7O3
Purity:
96.87% - 99.4%
Color and Shape:
Solid
Molecular weight:
391.38
Ref: TM-T4043
| 5mg | 50.00 € | ||
| 10mg | 73.00 € | ||
| 25mg | 121.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 345.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
IWP L6
CAS:1427782-89-5
IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Formula:
C25H20N4O2S2
Purity:
100% - 99.74%
Color and Shape:
Solid
Molecular weight:
472.58
Ref: TM-T2683
| 5mg | 53.00 € | ||
| 10mg | 72.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 190.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Wnt-C59
CAS:1243243-89-1
Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
Formula:
C25H21N3O
Purity:
99.56% - 99.91%
Color and Shape:
Solid
Molecular weight:
379.45
Ref: TM-T2242
| 2mg | 39.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 81.00 € | ||
| 25mg | 128.00 € | ||
| 50mg | 196.00 € | ||
| 100mg | 337.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Porcn-IN-1
CAS:2036044-77-4
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Formula:
C25H19FN4O
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
410.44
Ref: TM-T4438
| 1mg | 52.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 158.00 € | ||
| 25mg | 279.00 € | ||
| 50mg | 418.00 € | ||
| 100mg | 543.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
IWP-O1
CAS:2074607-48-8
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation …
Formula:
C26H20N6O
Purity:
99.12%
Color and Shape:
Solid
Molecular weight:
432.48
Ref: TM-T5342
| 2mg | 38.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 98.00 € | ||
| 25mg | 158.00 € | ||
| 50mg | 218.00 € | ||
| 100mg | 309.00 € | ||
| 200mg | 443.00 € | ||
| 1mL*10mM (DMSO) | 68.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
LGK974
CAS:1243244-14-5
LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal …
Formula:
C23H20N6O
Purity:
100% - ≥98%
Color and Shape:
Solid
Molecular weight:
396.44
Ref: TM-T2618
| 1mg | 48.00 € | ||
| 2mg | 64.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 161.00 € | ||
| 25mg | 297.00 € | ||
| 50mg | 535.00 € | ||
| 100mg | 760.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
IWP-2
CAS:686770-61-6
IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of …
Formula:
C22H18N4O2S3
Purity:
96.1% - 99.76%
Color and Shape:
Solid
Molecular weight:
466.6
Ref: TM-T2702
| 5mg | 50.00 € | ||
| 10mg | 66.00 € | ||
| 25mg | 109.00 € | ||
| 50mg | 196.00 € | ||
| 100mg | 293.00 € | ||
| 200mg | 440.00 € | ||
| 500mg | 720.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
GNF-6231
CAS:1243245-18-2
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
Formula:
C24H25FN6O2
Purity:
100% - 99.54%
Color and Shape:
Solid
Molecular weight:
448.49
Ref: TM-T11444
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 71.00 € | ||
| 25mg | 113.00 € | ||
| 50mg | 174.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Thursday 30 Jan 2025
WHN-88
CAS:2490686-86-5
WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion …
Formula:
C18H13I2N3O2
Color and Shape:
Liquid
Molecular weight:
557.12
Ref: TM-T89881
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 27 Feb 2025
