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Porcupine

Porcupine

Porcupine inhibitors are compounds that block the activity of Porcupine, an enzyme that is essential for the secretion and activity of Wnt proteins, which are key regulators of the Wnt signaling pathway. The Wnt pathway is involved in various developmental processes, including stem cell maintenance and differentiation. Inhibiting Porcupine is a strategic approach in cancer research, as it can disrupt Wnt-driven tumorigenesis. At CymitQuimica, we provide Porcupine inhibitors to aid your research in stem cell biology, developmental biology, and cancer therapy.

Found 9 products for "Porcupine".

  • CymitQuimica logo
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    WNT3Ap

    WNT3Ap is a peptide of the hairpin 2 domain of the WNT3A protein. It undergoes palmitoylation catalyzed by PORCN. WNT3Ap is crucial for elucidating the molecular mechanisms of the Wnt signaling pathway and acts as a key compound in the study of PORCN inhibitors.

    Ref: TM-TP4335

  • Porcn-IN-1
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    Porcn-IN-1

    CAS:
    Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
    Formula:C25H19FN4O
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:410.443

    Ref: TM-T4438

  • IWP-O1
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    IWP-O1

    CAS:
    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
    Formula:C26H20N6O
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:432.4766

    Ref: TM-T5342

  • LGK974
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    LGK974

    CAS:
    LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.
    Formula:C23H20N6O
    Purity:99.04% - >99.99%
    Color and Shape:Solid
    Molecular weight:396.4445

    Ref: TM-T2618

  • Wnt-C59
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    Wnt-C59

    CAS:
    Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
    Formula:C25H21N3O
    Purity:99.56% - 99.97%
    Color and Shape:Solid
    Molecular weight:379.45

    Ref: TM-T2242

  • IWP L6
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    IWP L6

    CAS:
    IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
    Formula:C25H20N4O2S2
    Purity:99.51% - >99.99%
    Color and Shape:White Solid
    Molecular weight:472.58

    Ref: TM-T2683

  • ETC-159
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    ETC-159

    CAS:
    ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
    Formula:C19H17N7O3
    Purity:96.87% - 99.30%
    Color and Shape:Solid
    Molecular weight:391.3834

    Ref: TM-T4043

  • IWP-2
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    IWP-2

    CAS:
    IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.
    Formula:C22H18N4O2S3
    Purity:96.1% - 99.86%
    Color and Shape:White Solid
    Molecular weight:466.599

    Ref: TM-T2702

  • GNF-6231
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    GNF-6231

    CAS:
    GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
    Formula:C24H25FN6O2
    Purity:99.74% - >99.99%
    Color and Shape:Solid
    Molecular weight:448.4927

    Ref: TM-T11444