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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1372 products of "Tyrosine Kinase/Adaptors"

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  • HER2/neu (654-662) GP2
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    HER2/neu (654-662) GP2

    CAS:
    <p>Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.</p>
    Formula:C42H77N9O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:884.11

    Ref: TM-TP1583

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    EGFR-IN-127

    <p>EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).</p>
    Color and Shape:Odour Solid

    Ref: TM-T200430

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    EGFR-IN-124

    <p>EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200720

  • Ack1 inhibitor 2
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    Ack1 inhibitor 2

    CAS:
    <p>Ack1 Inhibitor 2, also referred to as Example 259, effectively inhibits Ack1 with an IC50 value of 0.46 μM [1].</p>
    Formula:C23H23N5O2
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T85584

  • HDS 029
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    HDS 029

    CAS:
    <p>HDS 029 has a wide range of applications in life science related research.</p>
    Formula:C17H11ClFN5O
    Color and Shape:Solid
    Molecular weight:355.76

    Ref: TM-T37080

  • Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH
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    Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

    CAS:
    <p>Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.</p>
    Formula:C32H46N5O17P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:803.71

    Ref: TM-TP2085

  • HER2/neu (654-662) GP2 acetate
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    HER2/neu (654-662) GP2 acetate

    <p>GP2 acetate, from HER2 (654-662), triggers HLA-A2-restricted T cells to attack epithelial cancers.</p>
    Formula:C44H81N9O13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:944.17

    Ref: TM-TP1583L

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    PROTAC EGFR degrader 2

    <p>Potent PROTAC EGFR degrader 2; IC50: 4.0 nM, DC50: 36.51 nM; inhibits cell growth; for NTR-responsive synthesis.</p>
    Formula:C58H72ClFN12O8S
    Color and Shape:Solid
    Molecular weight:1151.78

    Ref: TM-T74333

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    Mecbotamab vedotin

    CAS:
    <p>Mecbotamab vedotin (BA301) is an inhibitory IgG1 antibody that targets human tyrosine kinase receptor AXL and the humanized murine monoclonal BA301 γ1 chain. It can be utilized in the preparation of immunoconjugates for research into cancers expressing the Axl type.</p>
    Color and Shape:Liquid

    Ref: TM-T9901A-225

  • BI-4732
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    BI-4732

    CAS:
    <p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>
    Formula:C32H36N10O2
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:592.69

    Ref: TM-T85354

  • PKI (5-24),amide
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    PKI (5-24),amide

    CAS:
    <p>PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.</p>
    Formula:C94H149N33O30
    Color and Shape:Solid
    Molecular weight:2221.4

    Ref: TM-T76482

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    Cetuximab MMAE

    <p>Cetuximab-MMAE, an antibody-drug conjugate (ADC), combines an EGFR-targeting antibody with Monomethyl auristatin E (MMAE) to investigate colorectal and head and neck cancers.</p>
    Color and Shape:Liquid
    Molecular weight:150 kDa

    Ref: TM-T9901A-219

  • PROTAC EGFR degrader 11
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    PROTAC EGFR degrader 11

    CAS:
    <p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>
    Formula:C49H64ClFN10O7S
    Color and Shape:Solid
    Molecular weight:991.61

    Ref: TM-T88077

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    EGFR/VEGFR2-IN-5

    <p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>
    Formula:C17H15N7O5S
    Color and Shape:Solid
    Molecular weight:429.41

    Ref: TM-T205483

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    Lumretuzumab

    CAS:
    <p>Lumretuzumab (RG-7116) is a humanized anti-HER3 monoclonal antibody with antitumor activity.</p>
    Purity:95.3% (SDS-PAGE); 96.4% (SEC-HPLC) - 95.3% (SDS-PAGE); 96.4% (SEC-HPLC)
    Color and Shape:Liquid

    Ref: TM-T76818

  • KYL peptide
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    KYL peptide

    CAS:
    <p>EphA4 inhibitor, Kd 0.8 μM, blocks EphA4-EphrinA5; avoids AβO damage, preserves spines &amp; LTP; long half-life (8-12h), neuroprotective.</p>
    Formula:C74H108N14O17
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1465.75

    Ref: TM-TP1895

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    Antiproliferative agent-57

    <p>Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor that suppresses VEGF secretion in SiHa cells under hypoxic conditions without inducing cytotoxicity (IC50=0.68 μM). It modulates the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells, thereby inhibiting the expression of HIF-1α and VEGF within tumor tissues.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200522

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    Inetetamab

    <p>Inetetamab is a recombinant humanized antibody targeting HER2 receptor domain IV, with anticancer activity, inducing pyroptosis in lung adenocarcinoma.</p>
    Purity:96.54% (SEC-HPLC) - 96.54% (SEC-HPLC)
    Color and Shape:Odour Liquid

    Ref: TM-T78335

  • SJF 1528
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    SJF 1528

    CAS:
    <p>Potent EGFR &amp; HER2 degrader; DC50 of 39.2 nM in OVCAR8, 736 nM in HeLa; has lapatinib, VHL ligand; inhibits HER2+ breast cancer (IC50=102 nM for SKBr3).</p>
    Formula:C55H57ClFN7O8S
    Color and Shape:Solid
    Molecular weight:1030.61

    Ref: TM-T36245

  • ErbB-2-binding peptide
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    ErbB-2-binding peptide

    CAS:
    <p>ErbB-2-binding peptide (HER2-binding peptide), a tumor-targeting peptide, holds potential for cancer research applications [1].</p>
    Formula:C43H60N8O11
    Color and Shape:Solid
    Molecular weight:864.98

    Ref: TM-T76542