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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1370 products of "Tyrosine Kinase/Adaptors"

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  • Src Inhibitor 3
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    Src Inhibitor 3

    CAS:
    <p>Src Inhibitor 3 blocks c-Src kinase (IC50 &lt;3 nM CSK HTRF, &lt;4 nM Caliper), boosting T cell growth from receptor signals.</p>
    Formula:C34H32ClFN8O4
    Purity:98.35%
    Color and Shape:Solid
    Molecular weight:671.12

    Ref: TM-T13000

  • AZ-23
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    AZ-23

    CAS:
    <p>AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.</p>
    Formula:C17H19ClFN7O
    Purity:99.4%
    Color and Shape:Solid
    Molecular weight:391.83

    Ref: TM-T14363

  • EGFR-IN-8
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Formula:C32H23ClF3N7O4
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:662.02

    Ref: TM-T11162

  • HER2-IN-21
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Color and Shape:Solid
    Molecular weight:394.447

    Ref: TM-T205331

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Formula:C10H8N2O
    Color and Shape:Solid
    Molecular weight:172.183

    Ref: TM-T204167

  • Tarloxotinib bromide
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    Tarloxotinib bromide

    CAS:
    Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.
    Formula:C24H24Br2ClN9O3
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:681.77

    Ref: TM-T13088

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Formula:C31H32N4O4
    Color and Shape:Solid
    Molecular weight:524.61

    Ref: TM-T206381

  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Formula:C13H14N2O2
    Color and Shape:Solid
    Molecular weight:230.262

    Ref: TM-T204439

  • CymitQuimica logo
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    DDR1-IN-8

    CAS:
    <p>DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, exhibiting IC50 values of 0.045 μM and 0.126 μM, respectively, and possesses antitumor activity.</p>
    Formula:C23H24F3N5O2
    Molecular weight:459.46

    Ref: TM-T209082

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Formula:C28H20BrN5O2
    Color and Shape:Solid
    Molecular weight:538.395

    Ref: TM-T206472

  • TrkA-IN-8
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    TrkA-IN-8

    CAS:
    <p>TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T205511

  • IGF-1R inhibitor-4
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    IGF-1R inhibitor-4

    CAS:
    <p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>
    Formula:C13H15ClN4O
    Color and Shape:Solid
    Molecular weight:278.737

    Ref: TM-T204141

  • Andamertinib
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formula:C31H36N8O3
    Color and Shape:Solid
    Molecular weight:568.669

    Ref: TM-T206579

  • FGFR4-IN-4
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    FGFR4-IN-4

    CAS:
    <p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>
    Formula:C28H32Cl2N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:603.5

    Ref: TM-T11280

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formula:C27H25ClN2O4
    Color and Shape:Solid
    Molecular weight:476.951

    Ref: TM-T204772

  • GENZ-882706
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    GENZ-882706

    CAS:
    <p>GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.</p>
    Formula:C26H25N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:455.51

    Ref: TM-T11390

  • ITK inhibitor 2
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    ITK inhibitor 2

    CAS:
    <p>ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.</p>
    Formula:C25H33N5O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:435.56

    Ref: TM-T11690

  • Pimicotinib hydrochloride
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    Pimicotinib hydrochloride

    CAS:
    <p>Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.</p>
    Formula:C22H25ClN6O3
    Color and Shape:Solid
    Molecular weight:456.925

    Ref: TM-T204920

  • DYR530
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    DYR530

    CAS:
    <p>DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.</p>
    Formula:C23H24FN7
    Color and Shape:Solid
    Molecular weight:417.48

    Ref: TM-T201243

  • CGP062464
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    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Formula:C18H14N4
    Color and Shape:Solid
    Molecular weight:286.331

    Ref: TM-T205732