CymitQuimica logo
Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

Show 13 more subcategories

Found 1372 products of "Tyrosine Kinase/Adaptors"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • DYR530
    Targetmol
    + Info

    DYR530

    CAS:
    <p>DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.</p>
    Formula:C23H24FN7
    Color and Shape:Solid
    Molecular weight:417.48

    Ref: TM-T201243

  • Enrupatinib
    Targetmol
    + Info

    Enrupatinib

    CAS:
    <p>Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.</p>
    Formula:C27H26N6O3
    Color and Shape:Solid
    Molecular weight:482.53

    Ref: TM-T201165

  • BPI-15086
    Targetmol
    + Info

    BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Formula:C29H33ClN8O4
    Color and Shape:Solid
    Molecular weight:593.08

    Ref: TM-T200004

  • c-Met-IN-26
    Targetmol
    + Info

    c-Met-IN-26

    CAS:
    c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.
    Formula:C24H19F2N9
    Color and Shape:Solid
    Molecular weight:471.46

    Ref: TM-T201085

  • Fanregratinib
    Targetmol
    + Info

    Fanregratinib

    CAS:
    Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
    Formula:C27H33ClN6O2
    Color and Shape:Solid
    Molecular weight:509.04

    Ref: TM-T201139

  • WS-11
    Targetmol
    + Info

    WS-11

    CAS:
    <p>WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust π-π interactions with PHE540, and p-π interactions with LYS430 within the active pocket.</p>
    Formula:C26H22FN9O2
    Color and Shape:Solid
    Molecular weight:511.51

    Ref: TM-T201126

  • MerTK-IN-1
    Targetmol
    + Info

    MerTK-IN-1

    CAS:
    <p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>
    Formula:C23H26N8O4
    Color and Shape:Solid
    Molecular weight:478.50

    Ref: TM-T200963

  • ES-072
    Targetmol
    + Info

    ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Formula:C25H27F3N8O2
    Color and Shape:Solid
    Molecular weight:528.53

    Ref: TM-T200087

  • Dyrk1A-IN-11
    Targetmol
    + Info

    Dyrk1A-IN-11

    CAS:
    <p>Dyrk1A-IN-11 (compound 166) is an effective inhibitor targeting dual-specificity tyrosine phosphorylation-regulated 1A (DYRK1A) with an EC50 of 0.0021 µM. Additionally, this compound inhibits the phosphorylation of Tau (Thr212) with an EC50 of 0.0361 µM.</p>
    Formula:C23H23F5N8O
    Color and Shape:Solid
    Molecular weight:522.47

    Ref: TM-T201128

  • BTK-IN-38
    Targetmol
    + Info

    BTK-IN-38

    CAS:
    <p>BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.</p>
    Formula:C27H26F2N4O2
    Color and Shape:Solid
    Molecular weight:476.52

    Ref: TM-T201231

  • c-Kit-IN-8
    Targetmol
    + Info

    c-Kit-IN-8

    CAS:
    <p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>
    Formula:C24H26FN5O4
    Color and Shape:Solid
    Molecular weight:467.49

    Ref: TM-T200947

  • c-Met-IN-2
    Targetmol
    + Info

    c-Met-IN-2

    CAS:
    <p>c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.</p>
    Formula:C24H21FN10O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.49

    Ref: TM-T10654

  • JBJ-09-063
    Targetmol
    + Info

    JBJ-09-063

    CAS:
    <p>JBJ-09-063: EGFR inhibitor, IC50s 0.147-0.396 nM for various mutants; hinders EGFR/Akt/ERK1/2 phosphorylation; targets TKI-sensitive/resistant lung cancer.</p>
    Formula:C31H29FN4O3S
    Color and Shape:Solid
    Molecular weight:556.65

    Ref: TM-T63939

  • BTK-IN-16
    Targetmol
    + Info

    BTK-IN-16

    CAS:
    <p>BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.</p>
    Formula:C15H14N4O2
    Purity:99.04%
    Color and Shape:Soild
    Molecular weight:282.3

    Ref: TM-T60542

  • ITK inhibitor 2
    Targetmol
    + Info

    ITK inhibitor 2

    CAS:
    <p>ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.</p>
    Formula:C25H33N5O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:435.56

    Ref: TM-T11690

  • D-69491 hydrochloride
    Targetmol
    + Info

    D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Formula:C25H26Cl2FN7O3
    Color and Shape:Solid
    Molecular weight:562.42

    Ref: TM-T201568

  • Pred17
    Targetmol
    + Info

    Pred17

    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Formula:C27H22BN3O
    Color and Shape:Solid
    Molecular weight:415.29

    Ref: TM-T201786

  • EGFR-IN-133
    Targetmol
    + Info

    EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Formula:C27H29F2N7O3
    Color and Shape:Solid
    Molecular weight:537.56

    Ref: TM-T201790

  • CGP062464
    Targetmol
    + Info

    CGP062464

    CAS:
    <p>CGP062464 is an inhibitor of the tyrosine kinase c-Src, with an IC50 of less than 50 nM. It is utilized in research related to osteoporosis and tumor-induced hypercalcemia.</p>
    Formula:C18H14N4
    Color and Shape:Solid
    Molecular weight:286.331

    Ref: TM-T205732

  • EGFR-IN-132
    Targetmol
    + Info

    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formula:C27H31N7O3
    Color and Shape:Solid
    Molecular weight:501.58

    Ref: TM-T201638