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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1375 products of "Tyrosine Kinase/Adaptors"

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  • EGFR-IN-130
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Formula:C27H25N3O6S
    Color and Shape:Solid
    Molecular weight:519.57

    Ref: TM-T201686

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    HER2-IN-12

    <p>HER2-IN-12 is an HER2 inhibitor with an IC50 value of 121 nM and can be used to study cancers such as breast cancer.</p>
    Formula:C17H18BrN5O2S
    Color and Shape:Solid
    Molecular weight:436.33

    Ref: TM-T62487

  • FGFR-IN-16
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    FGFR-IN-16

    CAS:
    <p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>
    Formula:C30H27Cl2N7O4
    Color and Shape:Solid
    Molecular weight:620.49

    Ref: TM-T201714

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    EGFR/HER2-IN-4

    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Color and Shape:Solid

    Ref: TM-T64253

  • G-744
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    G-744

    CAS:
    <p>G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM).</p>
    Formula:C29H29N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:527.64

    Ref: TM-T15365

  • TAS05567
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    TAS05567

    CAS:
    <p>TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).</p>
    Formula:C21H29N9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:439.51

    Ref: TM-T16995

  • EGFR-IN-126
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Formula:C28H28BrFN4O3
    Color and Shape:Solid
    Molecular weight:567.45

    Ref: TM-T200496

  • EGFR-IN-160
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    EGFR-IN-160

    CAS:
    <p>EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).</p>
    Formula:C15H12N2O4
    Color and Shape:Solid
    Molecular weight:284.27

    Ref: TM-T207600

  • 8-Br-cGMP-AM
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    8-Br-cGMP-AM

    CAS:
    <p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>
    Formula:C13H15BrN5O9P
    Color and Shape:Solid
    Molecular weight:496.16

    Ref: TM-T88538

  • DYRKs-IN-1
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    DYRKs-IN-1

    CAS:
    <p>DYRKs-IN-1 has antitumor activity.</p>
    Formula:C30H30ClN7O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:588.06

    Ref: TM-T11132

  • BIIB129
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    BIIB129

    CAS:
    <p>BIIB129 is a selective and brain-penetrant BTK covalent inhibitor used to study B-cell proliferation-related diseases.</p>
    Formula:C19H22N6O2
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:366.42

    Ref: TM-T88336

  • Vecabrutinib
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    Vecabrutinib

    CAS:
    <p>Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.</p>
    Formula:C22H24ClF4N7O2
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:529.92

    Ref: TM-T17220

  • Enbezotinib
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    Enbezotinib

    CAS:
    <p>Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.</p>
    Formula:C21H21FN6O3
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:424.43

    Ref: TM-T62285

  • AZ12601011
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    AZ12601011

    CAS:
    <p>AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.</p>
    Formula:C19H15N5
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:313.36

    Ref: TM-T10426

  • Zotizalkib
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    Zotizalkib

    CAS:
    <p>TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.</p>
    Formula:C21H20F3N5O3
    Purity:98.7%
    Color and Shape:Solid
    Molecular weight:447.41

    Ref: TM-T9414

  • AGL-2263
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    AGL-2263

    CAS:
    <p>AGL-2263 is a blocker of insulin receptor (IR)</p>
    Formula:C17H10N2O5
    Color and Shape:Solid
    Molecular weight:322.27

    Ref: TM-T14142

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  • EGFR-IN-7
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    EGFR-IN-7

    CAS:
    <p>EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.</p>
    Formula:C32H41BrN9O2P
    Purity:95.32% - 99.64%
    Color and Shape:Solid
    Molecular weight:694.6

    Ref: TM-T11161

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    HMBD-001

    <p>HMBD-001 is a humanized IgG1 monoclonal antibody inhibitor that targets HER3. By inhibiting the dimerization of HER3, HMBD-001 suppresses the growth and proliferation of tumor cells. It holds potential for research in cancer treatments, specifically for pancreatic cancer and non-small cell lung cancer.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-949

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    Discontinued product
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    Nimotuzumab (powder)

    CAS:
    <p>Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody that specifically targets the epidermal growth factor receptor (EGFR), possessing a dissociation constant (KD) of 0.21 nM. It blocks the binding to its ligand by targeting the extracellular domain of EGFR. Nimotuzumab exhibits strong antitumor activity by inducing both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), exerting cytolytic effects on target tumors.</p>
    Color and Shape:Liquid

    Ref: TM-T9901A-1025

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  • TLC9995-0188
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    TLC9995-0188

    CAS:
    <p>Tyrosine-protein kinase ABL, IC50: 1500 nM</p>
    Formula:C16H15N5
    Color and Shape:Yellow Solid
    Molecular weight:277.331

    Ref: TM-T116837

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    Discontinued product