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ALK

ALK

ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.

Found 158 products for "ALK".

products per page.
  • DDO-02267
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    DDO-02267

    CAS:
    DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.
    Formula:C18H12N2O7S
    Color and Shape:Solid
    Molecular weight:400.362

    Ref: TM-T204967

  • DA-0157
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    DA-0157

    CAS:
    DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.
    Formula:C31H43BrN7O2P
    Color and Shape:Solid
    Molecular weight:656.597

    Ref: TM-T205118

  • PF-06463922 acetate
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    PF-06463922 acetate

    CAS:
    PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.
    Formula:C23H23FN6O4
    Color and Shape:Solid
    Molecular weight:466.46

    Ref: TM-T70060

  • CDD-1115
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    CDD-1115

    CAS:
    CDD-1115 is a potent and selective BMPR2 inhibitor, with an IC50 of 1.8 nM and a Kiapp of 6.2 nM. It effectively suppresses gene expression mediated by bone morphogenetic proteins (BMPs). BMPs regulate cellular processes in various tissue types, such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.
    Formula:C32H30N6O3
    Color and Shape:Solid
    Molecular weight:546.619

    Ref: TM-T205172

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    ALK-IN-23

    ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.
    Formula:C26H29ClN8O3S
    Color and Shape:Solid
    Molecular weight:569.08

    Ref: TM-T64027

  • CEP-14083
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    CEP-14083

    CAS:
    CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.
    Formula:C31H30N6O2
    Color and Shape:Solid
    Molecular weight:518.61

    Ref: TM-T68538

  • DDO-2728
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    DDO-2728

    CAS:
    DDO-2728 is an ALKBH5 inhibitor (IC50 2.97 μM) with anti-AML activity.
    Formula:C28H17F3N4O7
    Color and Shape:Solid
    Molecular weight:578.45

    Ref: TM-T205009

  • ALK ligand-Linker Conjugate 1
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    ALK ligand-Linker Conjugate 1

    CAS:
    ALK ligand-Linker Conjugate 1 is an ALK ligand-connector conjugate used for the synthesis of PROTACALK degrader-4.
    Formula:C36H45N5O3
    Color and Shape:Solid
    Molecular weight:595.77

    Ref: TM-T212133

  • WZH-15-125
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    WZH-15-125

    CAS:
    WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.
    Formula:C33H45BrN8O5S
    Color and Shape:Solid
    Molecular weight:745.73

    Ref: TM-T210936

  • TGF-βRI inhibitor 3
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    TGF-βRI inhibitor 3

    CAS:
    TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.
    Formula:C21H21NO4
    Color and Shape:Solid
    Molecular weight:351.396

    Ref: TM-T205215

  • CEP-28122 mesylate hydrochloride
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    CEP-28122 mesylate hydrochloride

    CAS:
    CEP-28122 mesylate hydrochloride, a diaminopyrimidine derivative, is a potent, selective, and orally bioavailable ALK inhibitor with an IC50 of 1.9 nM, exhibiting antitumor and good pharmacokinetic activity [1].
    Formula:C29H40Cl2N6O6S
    Molecular weight:671.635

    Ref: TM-T86040

  • W23-1006
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    W23-1006

    CAS:
    W23-1006 is a selective covalent ALKBH5 inhibitor. By targeting the C200 residue to increase m6A levels, it suppresses growth and metastasis in TNBC models, utilized in research for RNA methylation and breast cancer therapy.
    Formula:C17H12BrN3O5
    Color and Shape:Brown Solid
    Molecular weight:418.2

    Ref: TM-T205034

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    (E)-Belizatinib

    CAS:
    (E)-Belizatinib ((E)-TSR-011) (compound 36) is the (E)-isomer of Belizatinib, and serves as a potent, highly selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK), with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. The compound exhibits over 61-fold selectivity against JAK2, SRC, and IGF1R, and demonstrates excellent efficacy and pharmacokinetic properties in rats and dogs. (E)-Belizatinib is applicable for research in ALK-driven cancers.
    Formula:C33H44FN5O3
    Molecular weight:577.75

    Ref: TM-T214502

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    ALK-IN-35

    CAS:
    ALK-IN-35 is an ALK degrader with an IC50 of 0.74 nM. It inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes the formation of partially unfolded ALK conformations, and induces proteasome-mediated degradation of ALK. ALK-IN-35 effectively inhibits cancer cell proliferation and is applicable in research related to non-small-cell lung cancer.
    Formula:C36H45ClN7O3P
    Molecular weight:690.21

    Ref: TM-T218942

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    ALK-IN-24

    CAS:
    ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. It also inhibits the insulin receptor kinase, with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells and hinders ALK-driven tumor growth in xenograft mouse models. It is applicable for research related to non-small cell lung cancer.
    Formula:C26H30ClN7O3S
    Molecular weight:556.08

    Ref: TM-T218696

  • AZ12601011
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    AZ12601011

    CAS:
    AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.
    Formula:C19H15N5
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:313.3559

    Ref: TM-T10426

  • Zotizalkib
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    Zotizalkib

    CAS:
    TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.
    Formula:C21H20F3N5O3
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:447.4104

    Ref: TM-T9414

  • CEP-28122 mesylate salt
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    CEP-28122 mesylate salt

    CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.
    Formula:C29H39ClN6O6S
    Color and Shape:Solid
    Molecular weight:635.17

    Ref: TM-T72317

    2mg
    Discontinued
    Discontinued product