ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 154 products for "ALK".
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DDO-2728
CAS:DDO-2728 is an ALKBH5 inhibitor (IC50 2.97 μM) with anti-AML activity.Formula:C28H17F3N4O7Color and Shape:SolidMolecular weight:578.45CEP-28122 mesylate hydrochloride
CAS:CEP-28122 mesylate hydrochloride, a diaminopyrimidine derivative, is a potent, selective, and orally bioavailable ALK inhibitor with an IC50 of 1.9 nM, exhibiting antitumor and good pharmacokinetic activity [1].Formula:C29H40Cl2N6O6SMolecular weight:671.64(E)-Belizatinib
CAS:(E)-Belizatinib ((E)-TSR-011) (compound 36) is the (E)-isomer of Belizatinib, and serves as a potent, highly selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK), with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. The compound exhibits over 61-fold selectivity against JAK2, SRC, and IGF1R, and demonstrates excellent efficacy and pharmacokinetic properties in rats and dogs. (E)-Belizatinib is applicable for research in ALK-driven cancers.Formula:C33H44FN5O3Molecular weight:577.75ALK-IN-35
CAS:ALK-IN-35 is an ALK degrader with an IC50 of 0.74 nM. It inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes the formation of partially unfolded ALK conformations, and induces proteasome-mediated degradation of ALK. ALK-IN-35 effectively inhibits cancer cell proliferation and is applicable in research related to non-small-cell lung cancer.Formula:C36H45ClN7O3PMolecular weight:690.21DDO-02267
CAS:DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.Formula:C18H12N2O7SColor and Shape:SolidMolecular weight:400.362ALK-IN-24
CAS:ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. It also inhibits the insulin receptor kinase, with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells and hinders ALK-driven tumor growth in xenograft mouse models. It is applicable for research related to non-small cell lung cancer.Formula:C26H30ClN7O3SMolecular weight:556.08PF-06463922 acetate
CAS:PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.Formula:C23H23FN6O4Color and Shape:SolidMolecular weight:466.46ALK-IN-23
ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.Formula:C26H29ClN8O3SColor and Shape:SolidMolecular weight:569.08CEP-14083
CAS:CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.Formula:C31H30N6O2Color and Shape:SolidMolecular weight:518.61TGF-βRI inhibitor 3
CAS:TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.Formula:C21H21NO4Color and Shape:SolidMolecular weight:351.396WZH-15-125
CAS:WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.Formula:C33H45BrN8O5SColor and Shape:SolidMolecular weight:745.73AZ12601011
CAS:AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Formula:C19H15N5Purity:99.61%Color and Shape:SolidMolecular weight:313.36Ref: TM-T10426
1mg94.00€5mg222.00€1mL*10mM (DMSO)245.00€10mg356.00€25mg690.00€50mg1,035.00€100mg1,431.00€Zotizalkib
CAS:TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.Formula:C21H20F3N5O3Purity:99.98%Color and Shape:SolidMolecular weight:447.41Ref: TM-T9414
1mg114.00€5mg268.00€1mL*10mM (DMSO)303.00€10mg439.00€25mg879.00€50mg1,395.00€100mg1,873.00€CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Formula:C29H39ClN6O6SColor and Shape:SolidMolecular weight:635.17
