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c-RET

c-RET

c-RET inhibitors target the RET (Rearranged during Transfection) proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth, differentiation, and survival. Abnormal activation of RET signaling can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of cancers such as medullary thyroid carcinoma and non-small cell lung cancer. Inhibiting c-RET can induce apoptosis in cancer cells and is a promising approach in targeted cancer therapy. At CymitQuimica, we offer a variety of high-quality c-RET inhibitors to support your research in oncology, signal transduction, and apoptosis.

Found 51 products of "c-RET"

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  • BT-13
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    BT-13

    CAS:
    <p>BT-13 activates RET receptor without GFLs, fostering sensory neuron neurite growth in vitro.</p>
    Formula:C23H27F4N3O4S
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:517.54

    Ref: TM-T10624

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    RET Ligand-Linker Conjugate-1

    <p>RET Ligand-Linker Conjugate-1 consists of a complex formed by a RET ligand and a linker, which can be utilized in the synthesis of QZ2135.</p>
    Formula:C40H44N10O
    Color and Shape:Solid
    Molecular weight:680.84

    Ref: TM-T205264

  • RET ligand-1
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    RET ligand-1

    CAS:
    <p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>
    Formula:C28H24F2N6O3
    Color and Shape:Solid
    Molecular weight:530.525

    Ref: TM-T204842

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    RET-IN-26

    <p>RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].</p>
    Color and Shape:Odour Solid

    Ref: TM-T81296

  • AD57 (hydrochloride)
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    AD57 (hydrochloride)

    CAS:
    <p>AD57, a polypharmacological agent, blocks RET kinase (IC50: 2 nM), disrupts related kinases, and hinders cancerous activities like invasion and proliferation.</p>
    Formula:C22H21ClF3N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:491.9

    Ref: TM-T22552

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    YW-N-7 TFA

    <p>YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.</p>
    Formula:C58H63F3N12O9
    Color and Shape:Solid
    Molecular weight:1129.19

    Ref: TM-T205127

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    RET ligand-3

    <p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>
    Formula:C38H42N10O3
    Color and Shape:Solid
    Molecular weight:686.81

    Ref: TM-T205712

  • RET-IN-28
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    RET-IN-28

    CAS:
    <p>RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.</p>
    Formula:C26H29N9
    Color and Shape:Solid
    Molecular weight:467.57

    Ref: TM-T203439

  • Zeteletinib hemiadipate
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    Zeteletinib hemiadipate

    CAS:
    <p>Zeteletinib hemiadipate (BOS-172738; DS-5010) is an oral RET kinase blocker with nanomolar potency and strong anti-tumor properties.</p>
    Formula:C56H56F6N8O12
    Color and Shape:Solid
    Molecular weight:1147.098

    Ref: TM-T39927

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    PLM-101

    <p>PLM-101 is an anticancer compound orally active against acute myeloid leukemia by targeting FLT3 and RET.</p>
    Formula:C22H22FN5O2
    Color and Shape:Solid
    Molecular weight:407.44

    Ref: TM-T78871

  • RET-IN-4
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    RET-IN-4

    CAS:
    <p>RET-IN-4: Oral RET inhibitor, IC50 ~1 nM for variants. Selective over JAK2/FLT3. Potent anticancer use.</p>
    Formula:C27H31FN10O2
    Color and Shape:Solid
    Molecular weight:546.611

    Ref: TM-T40097

  • BT44
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    BT44

    CAS:
    <p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>
    Formula:C28H27F4N3O4S
    Purity:99.87%
    Color and Shape:Soild
    Molecular weight:577.59

    Ref: TM-T67733

  • Compound TPX-0046
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    Compound TPX-0046

    CAS:
    <p>Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.</p>
    Formula:C21H21FN6O3
    Purity:99.94%
    Color and Shape:Soild
    Molecular weight:424.43

    Ref: TM-T67779

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    QZ2135

    <p>QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.</p>
    Formula:C53H54N12O4
    Color and Shape:Solid
    Molecular weight:923.07

    Ref: TM-T205359

  • trans-Pralsetinib
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    trans-Pralsetinib

    CAS:
    <p>trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).</p>
    Formula:C27H32FN9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:533.6

    Ref: TM-T10823

  • TPX-0046
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    TPX-0046

    CAS:
    <p>TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.</p>
    Formula:C21H21FN6O3
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:424.43

    Ref: TM-T35384

  • Pralsetinib
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    Pralsetinib

    CAS:
    <p>Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T</p>
    Formula:C27H32FN9O2
    Purity:97.88% - 99.8%
    Color and Shape:Solid
    Molecular weight:533.6

    Ref: TM-TQ0277

  • WHI-P180
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    WHI-P180

    CAS:
    <p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>
    Formula:C16H15N3O3
    Purity:99.21%
    Color and Shape:Solid
    Molecular weight:297.31

    Ref: TM-T2032

  • Treprostinil Sodium
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    Treprostinil Sodium

    CAS:
    <p>Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).</p>
    Formula:C23H33NaO5
    Purity:99.67% - >99.99%
    Color and Shape:Solid
    Molecular weight:412.5

    Ref: TM-T5171

  • GSK3179106
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    GSK3179106

    CAS:
    <p>GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM</p>
    Formula:C22H21F4N3O4
    Purity:99.8% - 99.90%
    Color and Shape:Solid
    Molecular weight:467.41

    Ref: TM-T5491

  • Selpercatinib
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    Selpercatinib

    CAS:
    <p>"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."</p>
    Formula:C29H31N7O3
    Purity:99.89% - >99.99%
    Color and Shape:Solid
    Molecular weight:525.6

    Ref: TM-T8222

  • Pyrazoloadenine
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    Pyrazoloadenine

    CAS:
    <p>Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.</p>
    Formula:C5H5N5
    Purity:99.02%
    Color and Shape:Beige Powder
    Molecular weight:135.13

    Ref: TM-T9366

  • BBT594
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    BBT594

    CAS:
    <p>BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.</p>
    Formula:C28H30F3N7O3
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:569.58

    Ref: TM-T7418

  • SPP-86
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    SPP-86

    CAS:
    <p>SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.</p>
    Formula:C16H15N5
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:277.32

    Ref: TM-T16923

  • RET V804M-IN-1
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    RET V804M-IN-1

    CAS:
    <p>RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).</p>
    Formula:C19H16N6O
    Purity:97.94% - 99.62%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T8467

  • WHI-P180 hydrochloride
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    WHI-P180 hydrochloride

    CAS:
    <p>WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.</p>
    Formula:C16H16ClN3O3
    Color and Shape:Solid
    Molecular weight:333.77

    Ref: TM-T61007

  • RET-IN-22
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    RET-IN-22

    CAS:
    <p>RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-</p>
    Formula:C29H31F3N6O4
    Color and Shape:Solid
    Molecular weight:584.59

    Ref: TM-T78683

  • RET-IN-15
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    RET-IN-15

    CAS:
    <p>RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>
    Formula:C27H28N8O2
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T63358

  • RET-IN-6
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    RET-IN-6

    CAS:
    <p>RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).</p>
    Formula:C30H29N7
    Color and Shape:Solid
    Molecular weight:487.6

    Ref: TM-T63249

  • DUN73423
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    DUN73423

    CAS:
    <p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>
    Formula:C19H16N6O
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T69644

  • RET-IN-8
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    RET-IN-8

    CAS:
    <p>RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>
    Formula:C27H30N6O3
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T63230

  • TRK II-IN-1
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    TRK II-IN-1

    CAS:
    <p>TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.</p>
    Formula:C29H31F3N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:564.6

    Ref: TM-T73033

  • RET-IN-16
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    RET-IN-16

    CAS:
    <p>RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.</p>
    Formula:C31H29F3N8O2
    Color and Shape:Solid
    Molecular weight:602.61

    Ref: TM-T73256

  • RET-IN-12
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    RET-IN-12

    CAS:
    <p>RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).</p>
    Formula:C30H30F3N5O4
    Color and Shape:Solid
    Molecular weight:581.59

    Ref: TM-T64103

  • RET-IN-23
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    RET-IN-23

    CAS:
    <p>RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.</p>
    Formula:C28H28FN11
    Purity:97.46%
    Color and Shape:Solid
    Molecular weight:537.59

    Ref: TM-T79099

  • RET-IN-3
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    RET-IN-3

    CAS:
    <p>RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.</p>
    Formula:C18H21N5O2
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:339.39

    Ref: TM-T9673

  • RET-IN-25
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    RET-IN-25

    CAS:
    <p>RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor that demonstrates efficacy against medullary thyroid carcinoma (MTC), exhibiting half-maximal</p>
    Formula:C22H17N3O5S
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T79726

  • RET-IN-17
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    RET-IN-17

    CAS:
    <p>RET-IN-17 inhibits RET kinase; may help in IBS pain and RET-activated cancers.</p>
    Formula:C27H28F4N4O4
    Color and Shape:Solid
    Molecular weight:548.53

    Ref: TM-T63877

  • Vepafestinib
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    Vepafestinib

    CAS:
    <p>Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].</p>
    Formula:C26H30N6O3
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:474.55

    Ref: TM-T9445

  • RET-IN-24
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    RET-IN-24

    CAS:
    <p>RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].</p>
    Formula:C27H26F2N8O
    Color and Shape:Solid
    Molecular weight:516.55

    Ref: TM-T79163

  • RET-IN-5
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    RET-IN-5

    CAS:
    <p>RET-IN-5 is a potent inhibitor of RET (IC50: 4.57 nM).</p>
    Formula:C29H26FN9O
    Color and Shape:Solid
    Molecular weight:535.57

    Ref: TM-T63772

  • FHND5071
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    FHND5071

    CAS:
    <p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>
    Formula:C30H30D3N9O
    Color and Shape:Solid
    Molecular weight:538.66

    Ref: TM-T78797

  • NSC194598
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    NSC194598

    CAS:
    <p>NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM.</p>
    Formula:C20H19N3O
    Color and Shape:Solid
    Molecular weight:317.38

    Ref: TM-T78203

  • FLT3/ITD-IN-4
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    FLT3/ITD-IN-4

    CAS:
    <p>FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).</p>
    Formula:C25H22N4O5
    Color and Shape:Solid
    Molecular weight:458.47

    Ref: TM-T62863

  • RET-IN-13
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    RET-IN-13

    CAS:
    <p>RET-IN-13: potent quinoline RET inhibitor; IC50 = 0.5 nM (WT), 0.9 nM (V804M); potential for RET-related tumor/intestinal disease research.</p>
    Formula:C32H33F4N5O3
    Color and Shape:Solid
    Molecular weight:611.63

    Ref: TM-T73248

  • RET-IN-10
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    RET-IN-10

    CAS:
    <p>RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).</p>
    Formula:C29H28N8OS
    Color and Shape:Solid
    Molecular weight:536.65

    Ref: TM-T63782

  • RET-IN-7
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    RET-IN-7

    CAS:
    <p>RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through</p>
    Formula:C22H24ClFN6O2
    Color and Shape:Solid
    Molecular weight:458.92

    Ref: TM-T62877

  • RET-IN-1
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    RET-IN-1

    CAS:
    <p>RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).</p>
    Formula:C29H31N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.61

    Ref: TM-T16735

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    WF-47-JS03

    <p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>
    Formula:C30H38N6O2
    Color and Shape:Solid
    Molecular weight:514.66

    Ref: TM-T63573

  • RET-IN-9
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    RET-IN-9

    CAS:
    <p>RET-IN-9 is a potent RET kinase inhibitor, potentially useful for studying RET-related diseases, including lung and thyroid cancer.</p>
    Formula:C26H27N9O
    Color and Shape:Solid
    Molecular weight:481.55

    Ref: TM-T63183

  • Enbezotinib
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    Enbezotinib

    CAS:
    <p>Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.</p>
    Formula:C21H21FN6O3
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:424.43

    Ref: TM-T62285