IGF-1R
IGF-1R inhibitors are compounds that specifically target and inhibit the Insulin-like Growth Factor 1 Receptor (IGF-1R), a receptor tyrosine kinase involved in cellular growth, development, and survival. IGF-1R signaling plays a significant role in cancer progression, making these inhibitors valuable in oncology research. At CymitQuimica, we offer IGF-1R inhibitors to support your research in cancer biology, endocrinology, and targeted therapy development.
Found 119 products for "IGF-1R".
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VRDN-002
VRDN-002 is a humanized monoclonal antibody (mAb) targeting IGF1R/CD221. It is designed to reduce inflammation and exophthalmos associated with thyroid eye disease (TED). Additionally, VPI-2690B is utilized in research related to Graves' ophthalmopathy.IRAB-B
IRAB-B is a human monoclonal antibody that targets INSR. As an insulin receptor (IR) antagonist, it is useful for research on insulin resistance and diabetes.Anti-Human IGF1R/CD221 Antibody
Anti-IGF1R/CD221 Antibody is a mAb targeting CD221 that inhibits tumor cell growth by blocking IGF-1 mediated signaling pathways.Anti-Human CD220/Insulin Receptor Antibody (IR 83-22)
Anti-CD220/Insulin Receptor Antibody (IR 83-22) is a mouse IgG1 chimeric antibody designed to target the human CD220/Insulin Receptor. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.XOMA 129
XOMA 129 is a human monoclonal antibody that targets the insulin receptor (INSR). This compound acts as an antagonist to the insulin receptor (IR), effectively inhibiting the decrease of blood glucose levels. XOMA 129 is applicable in the research of hypoglycemia.BM-131246
CAS:BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.Formula:C22H20N2O4SPurity:>99.99%Color and Shape:White SolidMolecular weight:408.47BIIB022
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting IGF1R/CD221. It inhibits the phosphorylation of IGF-1 and IGF-2-induced IGF-1R and its downstream substrates. BIIB022 is applicable for research in lung cancer, pancreatic cancer, and colon cancer. The recommended isotype control is Human IgG4 kappa, Isotype Control.D-(+)-Sorbose
CAS:D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.Formula:C6H12O6Color and Shape:SolidMolecular weight:180.16IMP2-IN-2
CAS:IMP2-IN-2: potent, selective IMP2 inhibitor; IC50s: 120.9 μM (RNA_A), 236.7 μM (RNA_B); used in cancer research.Formula:C22H19F3N2O3SColor and Shape:SolidMolecular weight:448.46I-OMe-Tyrphostin AG 538
CAS:I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formula:C17H12INO5Purity:98.8%Color and Shape:SolidMolecular weight:437.1854Protonstatin-1
CAS:Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formula:C8H5NO2S2Purity:99.77%Color and Shape:SolidMolecular weight:211.261NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurity:98.06% - 99.72%Color and Shape:SolidMolecular weight:412.255BMS-695735
CAS:BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.Formula:C26H31ClFN7OColor and Shape:SolidMolecular weight:512.02NBI-6024
CAS:NBI-6024, an altered peptide ligand (APL), serves as an epitope for interferon-gamma-producing T helper lymphocytes associated with inflammation in patientsFormula:C66H112N20O21Color and Shape:SolidMolecular weight:1521.72Tyrphostin AG 538
CAS:Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formula:C16H11NO5Purity:98.75%Color and Shape:SoildMolecular weight:297.2622ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Formula:C39H40N6O3Purity:98.34% - 99.32%Color and Shape:Pink SolidMolecular weight:640.77IGF-1R inhibitor-4
CAS:IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.Formula:C13H15ClN4OColor and Shape:SolidMolecular weight:278.737BMS-577098
CAS:BMS-577098 is an orally active ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) with an IC50 value of 0.016 μM, exhibiting antitumor properties.Formula:C28H33ClN6O3Molecular weight:537.06AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Color and Shape:Odour Liquid
