IGF-1R
IGF-1R inhibitors are compounds that specifically target and inhibit the Insulin-like Growth Factor 1 Receptor (IGF-1R), a receptor tyrosine kinase involved in cellular growth, development, and survival. IGF-1R signaling plays a significant role in cancer progression, making these inhibitors valuable in oncology research. At CymitQuimica, we offer IGF-1R inhibitors to support your research in cancer biology, endocrinology, and targeted therapy development.
Found 119 products for "IGF-1R".
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MSDC 0160
CAS:MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formula:C19H18N2O4SPurity:99.53% - 99.78%Color and Shape:SolidMolecular weight:370.422MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53% - 99.90%Color and Shape:Red SolidMolecular weight:314.3804XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.5412Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Formula:C28H38Cl3N5O3SPurity:99.85% - 99.99%Color and Shape:Yellow SolidMolecular weight:631.057Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurity:98.52% - 99.77%Color and Shape:SolidMolecular weight:558.14BMS-536924
CAS:BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFormula:C25H26ClN5O3Purity:99.02% - 99.70%Color and Shape:Brown SolidMolecular weight:479.96Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purity:99.17%Color and Shape:SolidMolecular weight:365.3826GSK1904529A
CAS:GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formula:C44H47F2N9O5SPurity:98.08% - 99.96%Color and Shape:SolidMolecular weight:851.963Figitumumab
CAS:Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDaVeligrotug
CAS:Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.Purity:96.7% (SDS-PAGE); 99.8% (SEC-HPLC) - 96.7% (SDS-PAGE); 99.8% (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:147.68 kDa (Predicted)Anti-Human IGFBP2 Antibody (M14)
Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.Color and Shape:Odour LiquidDusigitumab
CAS:Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.Purity:95% - 96.5% (SDS-PAGE); 97.1 % (SEC-HPLC)Color and Shape:Transparent LiquidMolecular weight:144.22 kDa (Predicted)IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColor and Shape:Lyophilized PowderMolecular weight:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.S961
CAS:S961 is a selective insulin receptor antagonist with IC50s of 0.048 nM (HIR-A), 0.027 nM (HIR-B), and 630 nM (HIGF-IR).Formula:C211H297N55O71S2Purity:99.44%Color and Shape:SolidMolecular weight:4804.13Elegrobart
CAS:Elegrobart is an immunoglobulin G1-κ monoclonal antibody that targets the human insulin-like growth factor 1 receptor (IGF1R). It shows potential for research into diseases linked to abnormal IGF1R signaling, particularly thyroid eye disease.IGF-1R modulator 1
CAS:IGF-1R modulator 1 modulates IGF-1R/IR signaling, reducing IGF-1R phosphorylation and inflammatory pathways in glia and mice, and altering tumor mTOR/AMPK, apoptosis, EMT, and adhesion models.Formula:C22H17N3O4Purity:99.75%Color and Shape:SolidMolecular weight:387.39BMS-754807
CAS:BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formula:C23H24FN9OPurity:99.69% - 99.94%Color and Shape:White SolidMolecular weight:461.4948H-1356
CAS:H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.Formula:C55H88N14O15S2Color and Shape:SolidMolecular weight:1249.5KU14R
CAS:KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.Formula:C13H14N2OPurity:98%Color and Shape:White SolidMolecular weight:214.26
