Ubiquitination
Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.
Subcategories of "Ubiquitination"
Found 107 products of "Ubiquitination"
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CB-5083
CAS:<p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>Formula:C24H23N5O2Purity:95.95% - 99.92%Color and Shape:SolidMolecular weight:413.47Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Formula:C18H13BrN2O4S2Purity:97.36%Color and Shape:SolidMolecular weight:465.34ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Formula:C24H18F3N3O3S2Purity:99.35% - >99.99%Color and Shape:SolidMolecular weight:517.54BC-1382
CAS:<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Formula:C23H29N3O5SPurity:99.15% - 99.94%Color and Shape:SolidMolecular weight:459.56NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Formula:C21H22ClNOPurity:99.74% - 99.88%Color and Shape:SolidMolecular weight:339.86SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.26GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Formula:C20H18N4OPurity:98.64%Color and Shape:SolidMolecular weight:330.38USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Formula:C21H21N3O2Purity:99.31%Color and Shape:SolidMolecular weight:347.41Subasumstat
CAS:<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Formula:C25H28ClN5O5S2Purity:97.02% - 98.22%Color and Shape:SolidMolecular weight:578.1CYM5442
CAS:<p>CYM5442 is an S1P agonist, targeting to Sphingosine.</p>Formula:C23H27N3O4Purity:98.02% - 99.48%Color and Shape:SolidMolecular weight:409.48IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Formula:C20H23N3O2Purity:99.3%Color and Shape:SolidMolecular weight:337.42LANOSTEROL
CAS:<p>Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.</p>Formula:C30H50OPurity:97.99% - 99.67%Color and Shape:SolidMolecular weight:426.72USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Formula:C26H22F4N6OPurity:99.69% - 99.88%Color and Shape:SolidMolecular weight:510.486BI8626
CAS:<p>BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cells</p>Formula:C25H28N8Purity:98.66%Color and Shape:SolidMolecular weight:440.54USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C22H18Cl2N2O3SPurity:98.48%Color and Shape:SolidMolecular weight:461.36FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formula:C27H28N6O5SPurity:98.76%Color and Shape:SolidMolecular weight:548.61DT204
CAS:<p>DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.</p>Formula:C19H13BrClNO5SPurity:99.17%Color and Shape:SolidMolecular weight:482.73USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C23H20Cl2N2O3SPurity:99.92%Color and Shape:SolidMolecular weight:475.39I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Formula:C26H23F3N6OPurity:99.41%Color and Shape:SolidMolecular weight:492.5Smurf1-IN-1
CAS:<p>Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy</p>Formula:C24H29ClN6O2Purity:98%Color and Shape:SolidMolecular weight:468.98OTUB1/USP8-IN-1
CAS:<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Formula:C22H16ClFN2O4Purity:98.59%Color and Shape:SoildMolecular weight:426.83CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Formula:C24H24N6OPurity:97.66%Color and Shape:SoildMolecular weight:412.49GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Formula:C17H12FN3Purity:97.09%Color and Shape:SolidMolecular weight:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Formula:C16H8N2O3Purity:99.72%Color and Shape:SolidMolecular weight:276.25NAcM-OPT
CAS:<p>NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).</p>Formula:C23H29Cl2N3OPurity:99.93%Color and Shape:SolidMolecular weight:434.4USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Formula:C17H16N6O2SPurity:98.84% - 99.59%Color and Shape:SolidMolecular weight:368.41P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Formula:C12H9NO3S2Purity:>99.99%Color and Shape:SolidMolecular weight:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Formula:C22H18N4Purity:98.2%Color and Shape:SolidMolecular weight:338.41Ubiquitination-IN-1
CAS:<p>Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).</p>Formula:C21H14F3N3O2SPurity:98.396% - 99.88%Color and Shape:SolidMolecular weight:429.42USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Formula:C26H28FN3O4SPurity:99.85%Color and Shape:SolidMolecular weight:497.58Cbl-b-IN-13
CAS:<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Formula:C29H30F3N5O2Purity:98%Color and Shape:SolidMolecular weight:537.58Cbl-b-IN-6
CAS:<p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>Formula:C30H32F5N5OPurity:98%Color and Shape:SolidMolecular weight:573.6Cbl-b-IN-10
CAS:<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Formula:C31H37F3N6OPurity:98%Color and Shape:SolidMolecular weight:566.66Cbl-b-IN-9
CAS:<p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>Formula:C30H33F3N6O2Purity:98%Color and Shape:SolidMolecular weight:566.62Cbl-b-IN-12
CAS:<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Formula:C28H29F3N6O2Purity:98%Color and Shape:SolidMolecular weight:538.56Cbl-b-IN-7
CAS:<p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>Formula:C29H31F4N5O2Purity:98%Color and Shape:SolidMolecular weight:557.58Skp2 inhibitor 2
CAS:<p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>Formula:C27H32N4OPurity:98%Color and Shape:SolidMolecular weight:428.57Cbl-b-IN-8
CAS:<p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>Formula:C35H44F3N7O3Purity:98%Color and Shape:SolidMolecular weight:667.76Cbl-b-IN-11
CAS:<p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>Formula:C31H35F5N6OPurity:98%Color and Shape:SolidMolecular weight:602.64USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Formula:C23H24ClN3O3Purity:99.82%Color and Shape:SolidMolecular weight:425.91LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Formula:C15H10N2O4SPurity:97.12%Color and Shape:SolidMolecular weight:314.32UPCDC30766
CAS:<p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>Formula:C30H32F2N6O3SPurity:98%Color and Shape:SolidMolecular weight:594.68FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Formula:C24H23F4N7O3Purity:98%Color and Shape:SolidMolecular weight:533.48PYZD-4409
CAS:<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Formula:C14H7ClFN3O5Purity:99.71%Color and Shape:SolidMolecular weight:351.67CC0651
CAS:<p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>Formula:C20H21Cl2NO6Purity:99.03%Color and Shape:SolidMolecular weight:442.29UC-764864
CAS:<p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>Formula:C19H18N2OSPurity:99.3%Color and Shape:SolidMolecular weight:322.42IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Formula:C23H19N5OPurity:99.3%Color and Shape:SolidMolecular weight:381.43BC-1293
CAS:<p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>Formula:C26H28N4O4SPurity:98.40%Color and Shape:SolidMolecular weight:492.59PRC1-IN-1
CAS:<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Formula:C24H19ClFN3O2Color and Shape:SolidMolecular weight:435.878
