Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1483 products of "Autophagy"
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MG-132
CAS:<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formula:C26H41N3O5Purity:95% - 99.99%Color and Shape:White To Off-White PowderMolecular weight:475.62Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purity:99.42% - 99.79%Color and Shape:SolidMolecular weight:443.85AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Formula:C27H25N5O2Purity:99.82%Color and Shape:SolidMolecular weight:451.52KB-R7943 mesylate
CAS:KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM.Formula:C17H21N3O6S2Purity:99.88% - ≥95%Color and Shape:SolidMolecular weight:427.5Briciclib
CAS:Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Formula:C19H23O10PSPurity:98% - 99.84%Color and Shape:SolidMolecular weight:474.42Hoechst 33342
CAS:Hoechst 33342 (bisBenzimide H 33342) is a benzimidazole fluorescent dye and a cell-permeable fluorescent DNA dye. High-Quality, Low-Cost!Formula:C27H28N6OPurity:98.12% - 99.75%Color and Shape:Yellow-Green PowderMolecular weight:452.55Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purity:99.97% - >99.99%Color and Shape:SolidMolecular weight:346.42Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formula:C37H56O11Purity:≥98%Color and Shape:Brown PowderMolecular weight:676.83Tempol
CAS:Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.Formula:C9H18NO2Purity:97% - 99.98%Color and Shape:4-Hydroxy-Tempo Appears As Orange Flakes Solid FlakesMolecular weight:172.25Peretinoin
CAS:Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.Formula:C20H30O2Purity:97.23%Color and Shape:SolidMolecular weight:302.45LC3-mHTT-IN-AN2
CAS:LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.Formula:C15H10O4Purity:98.82% - ≥98%Color and Shape:SolidMolecular weight:254.24Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purity:98.86% - 99.87%Color and Shape:SolidMolecular weight:436.3SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.4AS1842856
CAS:AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.Formula:C18H22FN3O3Purity:99.36% - >99.99%Color and Shape:SolidMolecular weight:347.38DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurity:97.63% - 99.82%Color and Shape:SolidMolecular weight:220.23Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Formula:C31H33FN6O3Purity:99.07% - 99.66%Color and Shape:SolidMolecular weight:556.63Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Formula:C21H25N7OPurity:98.6%Color and Shape:SolidMolecular weight:391.47XCT790
CAS:XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).Formula:C23H13F9N4O3SPurity:99% - 99.61%Color and Shape:SolidMolecular weight:596.4220-DEOXYINGENOL
CAS:20-DEOXYINGENOL is a natual product.Formula:C20H28O4Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:332.43U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Formula:C18H16N6S2Purity:99.61%Color and Shape:White SolidMolecular weight:380.49Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purity:98.3% - 99.33%Color and Shape:SolidMolecular weight:607.62Clinofibrate
CAS:Clinofibrate lowers lipids, blocks HMGCR (IC50: 0.47 mM), and controls cholesterol/triacylglycerides.Formula:C28H36O6Purity:>99.99%Color and Shape:White Crystalline PowderMolecular weight:468.58Alginic acid
CAS:Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.Formula:C14H22O13Purity:≥98%Color and Shape:SolidMolecular weight:398.317Tetrahydrocurcumin
CAS:Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.Formula:C21H24O6Purity:97.81% - 98.82%Color and Shape:Solid PowderMolecular weight:372.41Salbutamol hemisulfate
CAS:Salbutamol hemisulfate (Albuterol Sulfate) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 μM.Formula:C13H21NO3H2O4SPurity:99.35%Color and Shape:White Or Almost White Odourless PowderMolecular weight:576.70Acumapimod
CAS:Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).Formula:C22H19N5O2Purity:≥95%Color and Shape:SolidMolecular weight:385.42Lithocholic acid
CAS:Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM). High-Quality, Low-Cost!Formula:C24H40O3Purity:98% - 99.93%Color and Shape:Hexagonal Leaflets From Alc Prisms From Acetic Acid Powder (Ntp 1992)Molecular weight:376.57Scutellarein
CAS:Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.Formula:C15H10O6Purity:98.02% - 99.63%Color and Shape:SolidMolecular weight:286.24Vancomycin
CAS:Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibitingFormula:C66H75Cl2N9O24Purity:98.76% - 99.52%Color and Shape:Almost White PowderMolecular weight:1449.25URB-597
CAS:URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.Formula:C20H22N2O3Purity:97.20% - 98.24%Color and Shape:SolidMolecular weight:338.4Tropifexor
CAS:<p>Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.</p>Formula:C29H25F4N3O5SPurity:99.3% - 99.85%Color and Shape:SolidMolecular weight:603.58TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurity:99% - >99.99%Color and Shape:SolidMolecular weight:509.67Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21Valinomycin
CAS:Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes ParkinFormula:C54H90N6O18Purity:95.37% - 97.16%Color and Shape:White SolidMolecular weight:1111.32Eupatilin
CAS:Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.Formula:C18H16O7Purity:98.53% - 99%Color and Shape:SolidMolecular weight:344.32LYN-1604
CAS:<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>Formula:C33H43Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:584.62SR9009
CAS:SR9009, a REV-ERB agonist, modulates genes and circadian rhythms, reducing fat mass and improving metabolism in obese mice.Formula:C20H24ClN3O4SPurity:99.94% - >99.99%Color and Shape:SolidMolecular weight:437.94Kaempferol
CAS:<p>Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ.</p>Formula:C15H10O6Purity:98% - 99.41%Color and Shape:Yellow Needles From Alcohol And Water SolidMolecular weight:286.24DPN
CAS:<p>DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .</p>Formula:C15H13NO2Purity:99.01%Color and Shape:Off-White SolidMolecular weight:239.27Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purity:95.62% - 99.71%Color and Shape:SolidMolecular weight:581.49FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Formula:C23H24FN5O2Purity:97.21% - 98.68%Color and Shape:SolidMolecular weight:421.47Quercitrin
CAS:Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.Formula:C21H20O11Purity:98.89% - 99.66%Color and Shape:Yellow Crystals From Dil Methanol Or Ethanol SolidMolecular weight:448.38Quisinostat dihydrochloride
CAS:Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。Formula:C21H28Cl2N6O2Purity:97.13%Color and Shape:SolidMolecular weight:467.39GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:99.64% - 99.91%Color and Shape:SolidMolecular weight:348.42Neflamapimod
CAS:Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.Formula:C19H9Cl2F2N3OSPurity:97.88% - 99.75%Color and Shape:SolidMolecular weight:436.26Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Formula:C25H24F2N2O3Purity:98.55% - 99.73%Color and Shape:SolidMolecular weight:438.47SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:99.3% - >99.99%Color and Shape:SolidMolecular weight:405.42Milciclib
CAS:Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.Formula:C25H32N8OPurity:99.28%Color and Shape:SolidMolecular weight:460.57
