Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1529 products for "Autophagy".
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Taurine-13C2
CAS:Taurine-13C2 is a 13C-labeled version of Taurine (TMSM-2187). Taurine, a sulfur-containing amino acid, acts as an organic osmolyte involved in cell volume regulation, serves as a substrate for bile salt formation, and plays a role in controlling intracellular free calcium levels. Additionally, taurine can activate autophagy in adipocytes (fat cells).Formula:C2H7NO3SColor and Shape:SolidMolecular weight:127.13Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82G-quadruplex DNA fluorescence probe 1
Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.Formula:C27H31IN2O3Color and Shape:SolidMolecular weight:558.45ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72RK-682 (calcium salt)
CAS:RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Formula:C42H74CaO10Color and Shape:SolidMolecular weight:779.122MW-150 hydrochloride
CAS:MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.Formula:C24H24ClN5Color and Shape:SolidMolecular weight:417.93Desethyl chloroquine
CAS:Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.Formula:C16H22ClN3Purity:99.8%Color and Shape:SolidMolecular weight:291.82Cyanine 5 Tyramide methyl indole
Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.Formula:C40H47N3O8S2Color and Shape:SolidMolecular weight:761.956-Mercaptopurine-13C2,15N
CAS:6-Mercaptopurine-13C2,15N is a 6-Mercaptopurine (T0010) labeled with 13C and 15N. This compound is a purine analog that acts as an antagonist to endogenous purines and is widely used for its anti-leukemic and immunosuppressive properties.Formula:C5H4N4SColor and Shape:SolidMolecular weight:155.16TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86Chromomycin A2
CAS:Chromomycin A2, from marine actinomycetes, halts B. subtilis and various cancer cells; promotes autophagy in melanoma.Formula:C59H86O26Color and Shape:SolidMolecular weight:1211.31(R)-Hydroxychloroquine phosphate
CAS:(R)-Hydroxychloroquine ((R)-HCQ) phosphate is an isomer of Hydroxychloroquine. It inhibits insulin-metabolizing enzymes in the cytosolic fraction of liver homogenates in both healthy and diabetic rats.Formula:C18H28ClN3O5SColor and Shape:SolidMolecular weight:433.95Ambroxol-D5 hydrochloride
CAS:Ambroxol-D5 hydrochloride is the deuterated variant of Ambroxol hydrochloride. Ambroxol hydrochloride (T6234) (NA-872 hydrochloride) is the active metabolite of the precursor bromhexine and exhibits potent expectorant properties. It acts as a glucocerebrosidase (GCase) chaperone, enhancing the enzyme's activity. Additionally, Ambroxol hydrochloride (T6234) can induce autophagy in the lungs and holds potential for research in Parkinson's disease and neuronopathic Gaucher's disease.Formula:C13H19Br2ClN2OColor and Shape:SolidMolecular weight:419.60Pravastatin-D3 sodium
CAS:Pravastatin-D3 sodium is the deuterated form of Pravastatin sodium (T0672) salt. As a competitive inhibitor of HMG-CoA reductase, Pravastatin (CS-514) sodium salt has an IC50 of 5.6 μM in inhibiting sterol synthesis.Formula:C23H35NaO7Color and Shape:SolidMolecular weight:449.53Chlorotris(triphenylphosphine)copper
CAS:Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.Formula:C54H45ClCuP3Color and Shape:SolidMolecular weight:885.86Rapamycin-13C,D3
Rapamycin-13C,D3 is a potent and specific mTOR inhibitor that suppresses mTOR in HEK293 cells with an IC50 of 0.1 nM. It binds to FKBP12, thereby inhibiting mTORC1. Additionally, Rapamycin (T1537) serves as an autophagy (autophagy) activator and functions as an immunosuppressant.Color and Shape:Odour SolidLoperamide hydrochloride (Standard)
CAS:Loperamide hydrochloride (Standard) is the standard substance of Loperamide hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.Formula:C29H34Cl2N2O2Molecular weight:513.50Wortmannin (Standard)
CAS:Wortmannin (Standard) is the standard substance of Wortmannin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.Formula:C23H24O8Molecular weight:428.43Nitrendipine (Standard)
CAS:Nitrendipine (Standard) is the standard substance of Nitrendipine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.Formula:C18H20N2O6Molecular weight:360.36
