Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1529 products for "Autophagy".
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Telmisartan-D7
CAS:Telmisartan-D7 is a deuterium-labeled form of Telmisartan. Telmisartan (T1570) serves as a potent antagonist of the angiotensin II type 1 receptor, effectively inhibiting its activity with an IC50 of 9.2 nM.Formula:C33H30N4O2Color and Shape:SolidMolecular weight:521.66ATG16L1 stabilizer-1
ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.Formula:C45H62N14O5SColor and Shape:SolidMolecular weight:911.13Cy3-dCTP
Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.Formula:C43H51Li4N6O20P3S2Color and Shape:SolidMolecular weight:1156.71BRD4 degrader-5
BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.Formula:C35H42ClN7O2SColor and Shape:SolidMolecular weight:660.27(3R,5S)-Fluvastatin
CAS:(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.Formula:C24H26FNO4Color and Shape:SolidMolecular weight:411.47Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Formula:C27H48F3N9O7Color and Shape:SolidMolecular weight:667.72TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86Y040-7904
Y040-7904 is a potential mitochondrial autophagy activator. It enhances mitochondrial autophagy by facilitating the transport of mitochondria to autophagosomes and promoting the fusion of autophagosomes with autolysosomes. Y040-7904 induces mitochondrial autophagy through the SIRT1/FoxO3 pathway and upregulates the levels of Parkin, PINK1, and LC3II/I. Additionally, Y040-7904 reduces Aβ accumulation in both in vitro and in vivo Alzheimer's disease models.Color and Shape:Odour SolidMW-150 hydrochloride
CAS:MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.Formula:C24H24ClN5Color and Shape:SolidMolecular weight:417.93MeCY5-NHS ester triethylamine
MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].Formula:C42H56N4O10S2Color and Shape:SolidMolecular weight:841.04ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79CXCR4 antagonist 1
CAS:CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formula:C27H43N7Color and Shape:SolidMolecular weight:465.69Autocamtide 2, amide
Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.Formula:C65H119N23O19Purity:98%Color and Shape:SolidMolecular weight:1526.79(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Formula:C16H18F6N5O5PColor and Shape:SolidMolecular weight:505.314Hexidium iodide
CAS:Hexidium iodide fluoresces, stains mammalian cells & gram-positive bacteria, and binds to DNA with EDTA. Excitation/emission: ~518/600 nm.Formula:C25H28IN3Color and Shape:SolidMolecular weight:497.424KRH-3955 hydrochloride
CAS:KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Formula:C28H48Cl3N7Color and Shape:SolidMolecular weight:589.09PROTAC EGFR degrader 4
CAS:PROTAC EGFR degrader 4 targets mutant EGFR, degrades del19 and L858R/T790M (DC50: 0.51, 126 nM), and inhibits HCC827, H1975 cell growth (IC50: 0.83, 203.1 nM).Formula:C55H70N12O4SColor and Shape:SolidMolecular weight:995.29DMTr-4'-CF3-5-Me-U-CED phosphoramidite
DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.Formula:C42H50F3N4O8PColor and Shape:SolidMolecular weight:826.84Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82Indole-3-Glyoxylyl Chloride
CAS:Indole-3-glyoxylyl chloride (3-Indoleglyoxylyl chloride) can be used in chemical synthesis, such as bisindolylmaleimide.Formula:C10H6ClNO2Purity:99.72%Color and Shape:Yellow SolidMolecular weight:207.61Ref: TM-T0618
1mg92.00€2mg138.00€5mg224.00€1mL*10mM (DMSO)359.00€10mg374.00€25mg782.00€50mg1,279.00€100mg2,062.00€
