DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 94 products for "DUB".
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VCPIP1-IN-2
CAS:VCPIP1-IN-1 (Compound 076) is an inhibitor of VCPIP1.Formula:C14H13ClFN3O2Color and Shape:SolidMolecular weight:309.72XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Color and Shape:SolidMolecular weight:574.71USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurity:99.92%Color and Shape:White SolidMolecular weight:475.39USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Formula:C23H20Cl2N2O3SColor and Shape:SolidMolecular weight:475.39HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Formula:C26H30ClN3OPurity:98%Color and Shape:SolidMolecular weight:435.99USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurity:98.39%Color and Shape:Yellow SolidMolecular weight:461.368RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Formula:C14H16N8O2SColor and Shape:SolidMolecular weight:360.4USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Formula:C29H34N6O3Purity:98.27% - 99.09%Color and Shape:SolidMolecular weight:514.62FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Formula:C27H28N6O5SPurity:98.76%Color and Shape:White SolidMolecular weight:548.61BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formula:C18H16N2O2Purity:98.11%Color and Shape:SolidMolecular weight:292.33MF-095
CAS:MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Formula:C27H31N3O4SColor and Shape:SolidMolecular weight:493.62I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurity:99.66%Color and Shape:SolidMolecular weight:492.5Ref: TM-T73560
1mg105.00€5mg210.00€1mL*10mM (DMSO)230.00€10mg295.00€25mg424.00€50mg587.00€100mg880.00€LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Formula:C24H41NO3Color and Shape:SolidMolecular weight:391.59Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formula:C30H24N6O2S4Purity:98.31% - 99.32%Color and Shape:SolidMolecular weight:628.81SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purity:99.72%Color and Shape:SolidMolecular weight:276.25Ref: TM-T12926
1mg77.00€2mg101.00€5mg168.00€10mg253.00€25mg416.00€50mg580.00€100mg783.00€200mg1,054.00€USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurity:98.49% - 98.84%Color and Shape:SolidMolecular weight:368.416RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formula:C13H17N5O2SPurity:99.91%Color and Shape:SolidMolecular weight:307.37Ref: TM-T10188
1mg137.00€5mg281.00€1mL*10mM (DMSO)310.00€10mg484.00€25mg782.00€50mg1,071.00€100mg1,431.00€500mg2,898.00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purity:99.97%Color and Shape:SolidMolecular weight:279.33Ref: TM-T28284
1mg137.00€1mL*10mM (DMSO)239.00€5mg314.00€10mg427.00€25mg600.00€50mg798.00€100mg1,099.00€200mg1,468.00€GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purity:97.09%Color and Shape:SolidMolecular weight:277.3Ref: TM-T11485
1mg39.00€2mg50.00€5mg82.00€1mL*10mM (DMSO)90.00€10mg120.00€25mg236.00€50mg356.00€100mg537.00€200mg762.00€USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purity:99.37%Color and Shape:SolidMolecular weight:338.41OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purity:98.59%Color and Shape:SolidMolecular weight:426.83USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurity:99.85%Color and Shape:SolidMolecular weight:497.58Ref: TM-T36682
1mg137.00€5mg281.00€1mL*10mM (DMSO)309.00€10mg447.00€25mg713.00€50mg1,018.00€100mg1,369.00€500mg2,673.00€CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColor and Shape:SolidMolecular weight:463.6USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formula:C29H28ClFN4O2SColor and Shape:SolidMolecular weight:551.07USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formula:C24H28N4O3Color and Shape:SolidMolecular weight:420.5DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formula:C17H19N5OColor and Shape:SolidMolecular weight:309.37FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColor and Shape:SolidMolecular weight:447.6USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purity:99.82%Color and Shape:White SolidMolecular weight:425.91Ref: TM-T13268
1mg84.00€5mg177.00€1mL*10mM (DMSO)195.00€10mg249.00€25mg425.00€50mg605.00€100mg800.00€USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formula:C27H24F3N7OColor and Shape:SolidMolecular weight:519.52FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formula:C24H23F4N7O3Purity:99.76%Color and Shape:SolidMolecular weight:533.48USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purity:98%Color and Shape:SolidMolecular weight:568.59LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurity:97.12%Color and Shape:SolidMolecular weight:314.32USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormula:C27H23F3N8OColor and Shape:SolidMolecular weight:532.52USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formula:C29H27F3N8OColor and Shape:SolidMolecular weight:560.57IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurity:99.3%Color and Shape:White SolidMolecular weight:381.43USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formula:C41H43N7O4SPurity:98%Color and Shape:SolidMolecular weight:729.89FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formula:C21H19N5O2Color and Shape:SolidMolecular weight:373.41USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formula:C27H28ClN3O3SPurity:95.90% - 95.90%Color and Shape:SolidMolecular weight:510.05FT709
CAS:FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formula:C23H22N4O7SPurity:98.13%Color and Shape:White SolidMolecular weight:498.51MTX115325
CAS:MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].Formula:C18H16N6O2Color and Shape:SolidMolecular weight:348.36USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formula:C26H29ClN4O3SColor and Shape:SolidMolecular weight:513.05USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formula:C22H23N3O3Purity:99.50% - 99.81%Color and Shape:SolidMolecular weight:377.44USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Formula:C19H20ClN3O5SPurity:99.76%Color and Shape:SoildMolecular weight:437.9Ref: TM-T60130
1mg52.00€5mg111.00€1mL*10mM (DMSO)123.00€10mg169.00€25mg295.00€50mg447.00€100mg670.00€VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formula:C13H15ClN2O2Purity:99.3%Color and Shape:White SolidMolecular weight:266.72Ref: TM-T88664
1mg47.00€5mg92.00€1mL*10mM (DMSO)101.00€10mg145.00€25mg281.00€50mg447.00€100mg715.00€200mg964.00€
