Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
Found 46 products of "Sigma receptor"
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Roluperidone
CAS:<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Formula:C22H23FN2O2Purity:96.46% - 97.77%Color and Shape:SolidMolecular weight:366.43Glycerol phenylbutyrate
CAS:<p>Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).</p>Formula:C33H38O6Purity:98.54% - 99.74%Color and Shape:SolidMolecular weight:530.65Blonanserin
CAS:<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Formula:C23H30FN3Purity:99.85%Color and Shape:SolidMolecular weight:367.5AD353
<p>AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.</p>Formula:C23H30N2O2Color and Shape:SolidMolecular weight:366.5σ1 Receptor ligand 1
<p>σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.</p>Formula:C22H28N2O2Color and Shape:SolidMolecular weight:352.47PD 144418 oxalate
CAS:<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Formula:C20H24N2O5Purity:98.76%Color and Shape:SolidMolecular weight:372.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Formula:C24H32N2O8Purity:98.12%Color and Shape:SolidMolecular weight:476.52UKH-1114
CAS:<p>UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.</p>Formula:C22H24F3NOColor and Shape:SolidMolecular weight:375.43AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Formula:C25H30N2O5Purity:98%Color and Shape:SolidMolecular weight:438.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Formula:C22H26N2OColor and Shape:SolidMolecular weight:334.45σ1R-IN-1
<p>σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.</p>Formula:C15H22N2Color and Shape:SolidMolecular weight:230.35AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Formula:C22H28N2Purity:98%Color and Shape:SolidMolecular weight:320.47AB21 HCl
<p>AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.</p>Formula:C23H29ClN2OPurity:99.91%Color and Shape:SolidMolecular weight:384.2S1R agonist 2 hydrochloride
<p>Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.</p>Formula:C21H28ClNOPurity:98%Color and Shape:SolidMolecular weight:345.914-IBP
CAS:<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Formula:C19H21IN2OPurity:98.99%Color and Shape:SolidMolecular weight:420.29Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Formula:C19H24ClNOPurity:99.57% - 99.9%Color and Shape:SolidMolecular weight:317.85Cutamesine dihydrochloride
CAS:<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Formula:C23H32N2O2·2HClPurity:99.96%Color and Shape:SolidMolecular weight:441.43σ1 Receptor antagonist-1
CAS:<p>σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.</p>Formula:C21H23NOSPurity:99.8%Color and Shape:SolidMolecular weight:337.48BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Formula:C15H24Br2Cl2N2Purity:97.81%Color and Shape:SolidMolecular weight:463.08PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Formula:C19H28ClNO3Purity:99.54%Color and Shape:SolidMolecular weight:353.88
