Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
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Blonanserin
CAS:132810-10-7
Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like …
Formula:
C23H30FN3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
367.5
Ref: TM-T1180
| 5mg | 42.00 € | ||
| 10mg | 57.00 € | ||
| 25mg | 97.00 € | ||
| 50mg | 127.00 € | ||
| 100mg | 174.00 € | ||
| 200mg | 300.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Glycerol phenylbutyrate
CAS:611168-24-2
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is …
Formula:
C33H38O6
Purity:
99.00% - 99.74%
Color and Shape:
Solid
Molecular weight:
530.65
Ref: TM-T15393
| 10mg | 46.00 € | ||
| 25mg | 64.00 € | ||
| 50mg | 86.00 € | ||
| 100mg | 142.00 € | ||
| 200mg | 203.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Roluperidone
CAS:359625-79-9
Roluperidone (CYR-101) is a novel cyclic amide derivative.
Formula:
C22H23FN2O2
Purity:
96.46% - 97.77%
Color and Shape:
Solid
Molecular weight:
366.43
Ref: TM-T15034
| 1mg | 36.00 € | ||
| 5mg | 63.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 161.00 € | ||
| 50mg | 255.00 € | ||
| 100mg | 369.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM …
Formula:
C25H30N2O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
438.52
Ref: TM-T78916
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
BMY-14802
CAS:105565-56-8
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of …
Formula:
C18H22F2N4O
Purity:
98.93%
Color and Shape:
Soild
Molecular weight:
348.39
Ref: TM-T67739
| 1mg | 40.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 267.00 € | ||
| 50mg | 437.00 € | ||
| 100mg | 645.00 € | ||
| 500mg | 1,327.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic …
Formula:
C26H27N3O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
397.51
Ref: TM-T78734
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8
Formula:
C24H32N2O8
Purity:
98.54%
Color and Shape:
Liquid
Molecular weight:
476.52
Ref: TM-T62396L
| 5mg | 62.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 189.00 € | ||
| 1mL*10mM (DMSO) | 68.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces …
Formula:
C23H29ClN2O
Purity:
99.89%
Color and Shape:
Liquid
Molecular weight:
384.2
Ref: TM-T77340L
| 1mg | 182.00 € | ||
| 5mg | 401.00 € | ||
| 10mg | 593.00 € | ||
| 25mg | 917.00 € | ||
| 50mg | 1,268.00 € | ||
| 100mg | 1,706.00 € | ||
| 500mg | 3,418.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for …
Formula:
C22H28N2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
320.47
Ref: TM-T78915
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
PD 144418 oxalate
CAS:1794760-28-3
PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; …
Formula:
C20H24N2O5
Purity:
99.08%
Color and Shape:
Solid
Molecular weight:
372.42
Ref: TM-T39211
| 1mg | 58.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 314.00 € | ||
| 50mg | 457.00 € | ||
| 100mg | 668.00 € | ||
| 200mg | 916.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 …
Formula:
C21H28ClNO
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
345.91
Ref: TM-T78087
| 2mg | 94.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
KSK67
CAS:2566715-93-1
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects …
Formula:
C22H27N3O2
Purity:
99.11%
Color and Shape:
Soild
Molecular weight:
365.47
Ref: TM-T77593
| 1mg | 73.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 226.00 € | ||
| 25mg | 456.00 € | ||
| 50mg | 785.00 € | ||
| 100mg | 1,355.00 € | ||
| 500mg | 2,732.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
S1R agonist 2
CAS:150085-21-5
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for …
Formula:
C21H27NO
Purity:
99.04%
Color and Shape:
Liquid
Molecular weight:
309.45
Ref: TM-T72059
| 1mg | 46.00 € | ||
| 5mg | 90.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 267.00 € | ||
| 50mg | 406.00 € | ||
| 100mg | 600.00 € | ||
| 500mg | 1,268.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's …
Formula:
C22H26N2O
Color and Shape:
Liquid
Molecular weight:
334.45
Ref: TM-T74813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
AF-710B
CAS:1235733-73-9
AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors …
Formula:
C20H27N3OS
Purity:
98.62% - 99.89%
Color and Shape:
Solid
Molecular weight:
357.51
Ref: TM-T23649
| 1mg | 311.00 € | ||
| 2mg | 462.00 € | ||
| 5mg | 737.00 € | ||
| 10mg | 1,044.00 € | ||
| 25mg | 1,549.00 € | ||
| 50mg | 2,039.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
S1RA
CAS:878141-96-9
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating …
Formula:
C20H23N3O2
Purity:
99.45%
Color and Shape:
Solid
Molecular weight:
337.42
Ref: TM-T1865
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 131.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 315.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
KB-5492 free base
CAS:113594-64-2
KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used …
Formula:
C23H30N2O6
Purity:
97.72% - 99.07%
Color and Shape:
Liquid
Molecular weight:
430.49
Ref: TM-T62396
| 2mg | 41.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 123.00 € | ||
| 50mg | 174.00 € | ||
| 100mg | 257.00 € | ||
| 500mg | 634.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Opipramol
CAS:315-72-0
Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic …
Formula:
C23H29N3O
Purity:
99.84% - 99.98%
Color and Shape:
Liquid
Molecular weight:
363.5
Ref: TM-T61376
| 2mg | 94.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
PRE-084 hydrochloride
CAS:75136-54-8
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Formula:
C19H28ClNO3
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
353.88
Ref: TM-T3198L
| 5mg | 44.00 € | ||
| 10mg | 64.00 € | ||
| 25mg | 119.00 € | ||
| 50mg | 204.00 € | ||
| 100mg | 364.00 € | ||
| 200mg | 553.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Amitriptyline
CAS:50-48-6
Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.
Formula:
C20H23N
Purity:
98.24% - 99.64%
Color and Shape:
Crystals Solid
Molecular weight:
277.4
Ref: TM-T22240
| 10mg | 46.00 € | ||
| 25mg | 67.00 € | ||
| 50mg | 88.00 € | ||
| 100mg | 129.00 € | ||
| 200mg | 185.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
