Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
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KB-5492 free base
CAS:113594-64-2
KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used …
Formula:
C23H30N2O6
Purity:
97.72% - 99.07%
Color and Shape:
Liquid
Molecular weight:
430.49
Ref: TM-T62396
| 2mg | 42.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 126.00 € | ||
| 50mg | 177.00 € | ||
| 100mg | 263.00 € | ||
| 500mg | 647.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Friday 2 May 2025
Cutamesine dihydrochloride
CAS:165377-44-6
Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving …
Formula:
C23H32N2O2·2HCl
Purity:
98.83% - 99%
Color and Shape:
Solid
Molecular weight:
441.43
Ref: TM-T3597
| 2mg | 44.00 € | ||
| 5mg | 63.00 € | ||
| 10mg | 100.00 € | ||
| 25mg | 224.00 € | ||
| 50mg | 427.00 € | ||
| 100mg | 630.00 € | ||
| 500mg | 1,320.00 € | ||
| 1mL*10mM (DMSO) | 115.00 € |
Estimated delivery in United States, on Monday 5 May 2025
4-IBP
CAS:155798-08-6
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 …
Formula:
C19H21IN2O
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
420.29
Ref: TM-T4596
| 5mg | 37.00 € | ||
| 10mg | 59.00 € | ||
| 25mg | 110.00 € | ||
| 50mg | 187.00 € | ||
| 100mg | 274.00 € | ||
| 200mg | 406.00 € | ||
| 1mL*10mM (DMSO) | 42.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Amitriptyline
CAS:50-48-6
Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.
Formula:
C20H23N
Purity:
98.24% - 99.64%
Color and Shape:
Crystals Solid
Molecular weight:
277.4
Ref: TM-T22240
| 10mg | 47.00 € | ||
| 25mg | 67.00 € | ||
| 50mg | 89.00 € | ||
| 100mg | 131.00 € | ||
| 200mg | 188.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Siramesine
CAS:147817-50-3
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to …
Formula:
C30H31FN2O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
454.58
Ref: TM-T4620
| 5mg | 197.00 € | ||
| 10mg | 299.00 € | ||
| 25mg | 455.00 € | ||
| 50mg | 702.00 € |
Estimated delivery in United States, on Monday 5 May 2025
σ1 Receptor antagonist-1
CAS:1204401-49-9
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
Formula:
C21H23NOS
Purity:
99.80%
Color and Shape:
Solid
Molecular weight:
337.48
Ref: TM-T9244
| 2mg | 38.00 € | ||
| 5mg | 55.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 269.00 € | ||
| 100mg | 391.00 € | ||
| 200mg | 562.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Monday 5 May 2025
EST64454 hydrochloride
CAS:1950569-11-5
EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the …
Formula:
C18H23ClF2N4O2
Purity:
99.15%
Color and Shape:
Solid
Molecular weight:
400.85
Ref: TM-T8834
| 2mg | 44.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 197.00 € | ||
| 50mg | 320.00 € | ||
| 100mg | 509.00 € | ||
| 200mg | 698.00 € | ||
| 1mL*10mM (DMSO) | 81.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Siramesine hydrochloride
CAS:224177-60-0
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown …
Formula:
C30H32ClFN2O
Purity:
100% - 99.75%
Color and Shape:
Solid
Molecular weight:
491.04
Ref: TM-T1885
| 1mg | 60.00 € | ||
| 2mg | 88.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 173.00 € | ||
| 25mg | 354.00 € | ||
| 50mg | 528.00 € | ||
| 100mg | 743.00 € | ||
| 1mL*10mM (DMSO) | 120.00 € |
Estimated delivery in United States, on Monday 5 May 2025
PRE-084 hydrochloride
CAS:75136-54-8
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Formula:
C19H28ClNO3
Purity:
99.54%
Color and Shape:
Solid
Molecular weight:
353.88
Ref: TM-T3198L
| 5mg | 44.00 € | ||
| 10mg | 65.00 € | ||
| 25mg | 120.00 € | ||
| 50mg | 207.00 € | ||
| 100mg | 369.00 € | ||
| 200mg | 565.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Monday 5 May 2025
BD 1008 dihydrobromide
CAS:138356-09-9
BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.
Formula:
C15H24Br2Cl2N2
Purity:
97.81%
Color and Shape:
Solid
Molecular weight:
463.08
Ref: TM-T21788
| 1mg | 65.00 € | ||
| 5mg | 133.00 € | ||
| 10mg | 202.00 € | ||
| 25mg | 341.00 € | ||
| 50mg | 507.00 € | ||
| 100mg | 722.00 € | ||
| 1mL*10mM (DMSO) | 157.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Dimemorfan phosphate
CAS:36304-84-4
Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a …
Formula:
C18H25N·H3O4P
Purity:
99.65%
Color and Shape:
Solid
Molecular weight:
353.4
Ref: TM-T5027
| 100mg | 44.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Blarcamesine hydrochloride
CAS:195615-84-0
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
Formula:
C19H24ClNO
Purity:
98.62% - 99.57%
Color and Shape:
Solid
Molecular weight:
317.85
Ref: TM-T4111
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 139.00 € | ||
| 25mg | 255.00 € | ||
| 50mg | 457.00 € | ||
| 100mg | 655.00 € | ||
| 500mg | 1,406.00 € | ||
| 1mL*10mM (DMSO) | 97.00 € |
Estimated delivery in United States, on Monday 5 May 2025
S1RA hydrochloride
CAS:1265917-14-3
S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, …
Formula:
C20H24ClN3O2
Purity:
98% - 99.84%
Color and Shape:
Solid
Molecular weight:
373.87
Ref: TM-T4229
| 1mg | 38.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 216.00 € | ||
| 50mg | 354.00 € | ||
| 100mg | 518.00 € | ||
| 500mg | 1,026.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Blarcamesine
CAS:195615-83-9
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
Formula:
C19H23NO
Purity:
99.87%
Color and Shape:
Solid
Molecular weight:
281.39
Ref: TM-T7780
| 5mg | 48.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 104.00 € | ||
| 50mg | 170.00 € | ||
| 100mg | 283.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Monday 5 May 2025
BD1063 dhydrochloride
CAS:206996-13-6
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
Formula:
C13H20Cl4N2
Purity:
99.52% - ≥95%
Color and Shape:
Solid
Molecular weight:
346.12
Ref: TM-T7488
| 2mg | 48.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 187.00 € | ||
| 50mg | 339.00 € | ||
| 100mg | 499.00 € | ||
| 200mg | 702.00 € | ||
| 500mg | 1,074.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Ditolylguanidine
CAS:97-39-2
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).
Formula:
C15H17N3
Purity:
98.42%
Color and Shape:
White To Pinkish Solid Powder
Molecular weight:
239.32
Ref: TM-T5969
| 1g | 35.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Pre-084
CAS:138847-85-5
Pre-084 is a high affinity, selective σ1 agonist.
Formula:
C19H28ClNO3
Purity:
99.91%
Color and Shape:
Solid
Molecular weight:
353.88
Ref: TM-T3198
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 5 May 2025
BD-1047 dihydrobromide
CAS:138356-21-5
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in …
Formula:
C13H22Br2Cl2N2
Purity:
98.13% - 99.39%
Color and Shape:
Solid
Molecular weight:
437.04
Ref: TM-T1740
| 1mg | 37.00 € | ||
| 2mg | 48.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 290.00 € | ||
| 100mg | 490.00 € | ||
| 1mL*10mM (DMSO) | 74.00 € |
Estimated delivery in United States, on Monday 5 May 2025
4-PPBP maleate
CAS:201216-39-9
4-PPBP maleate: potent σ1 agonist, selective NR1a/2B NMDA antagonist, neuroprotective.
Formula:
C25H31NO4
Purity:
99.54%
Color and Shape:
Solid
Molecular weight:
409.52
Ref: TM-T22513
| 5mg | 48.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 135.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 313.00 € | ||
| 200mg | 442.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Monday 16 Jun 2025
PD 144418
CAS:154130-99-1
PD 144418 displays potential antipsychotic activity.
Formula:
C18H22N2O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
282.38
Ref: TM-T16445
| 25mg | 698.00 € | ||
| 50mg | 908.00 € | ||
| 100mg | 1,369.00 € |
Estimated delivery in United States, on Monday 16 Jun 2025
