Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
Found 46 products of "Sigma receptor"
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Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFormula:C30H32ClFN2OPurity:99.72% - >99.99%Color and Shape:SolidMolecular weight:491.04Ref: TM-T1885
1mg57.00€2mg84.00€5mg105.00€10mg170.00€25mg334.00€50mg500.00€100mg705.00€1mL*10mM (DMSO)114.00€PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Formula:C19H28ClNO3Purity:99.54%Color and Shape:SolidMolecular weight:353.88Ref: TM-T3198L
5mg44.00€10mg65.00€25mg120.00€50mg207.00€100mg369.00€200mg565.00€1mL*10mM (DMSO)72.00€BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.
Formula:C15H24Br2Cl2N2Purity:97.81%Color and Shape:SolidMolecular weight:463.08Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Formula:C18H25N·H3O4PPurity:99.65%Color and Shape:SolidMolecular weight:353.4Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Formula:C19H24ClNOPurity:99.57% - 99.9%Color and Shape:SolidMolecular weight:317.85Ref: TM-T4111
1mg35.00€2mg48.00€5mg70.00€10mg104.00€25mg207.00€50mg359.00€100mg588.00€200mg833.00€1mL*10mM (DMSO)78.00€BD-1047 dihydrobromide
CAS:BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacyFormula:C13H22Br2Cl2N2Purity:98.13% - 99.39%Color and Shape:SolidMolecular weight:437.04Ref: TM-T1740
1mg37.00€2mg48.00€5mg73.00€10mg95.00€25mg168.00€50mg290.00€100mg490.00€1mL*10mM (DMSO)74.00€Blarcamesine
CAS:Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
Formula:C19H23NOPurity:99.87%Color and Shape:SolidMolecular weight:281.39Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Formula:C15H17N3Purity:98.42%Color and Shape:White To Pinkish Solid PowderMolecular weight:239.32S1RA hydrochloride
CAS:S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki >Formula:C20H24ClN3O2Purity:98% - 99.84%Color and Shape:SolidMolecular weight:373.87Ref: TM-T4229
1mg35.00€5mg75.00€10mg105.00€25mg205.00€50mg334.00€100mg492.00€500mg973.00€1mL*10mM (DMSO)84.00€KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Formula:C23H30N2O6Purity:97.10% - 97.94%Color and Shape:SolidMolecular weight:430.49Ref: TM-T62396
2mg39.00€5mg58.00€10mg82.00€25mg119.00€50mg168.00€100mg249.00€500mg613.00€1mL*10mM (DMSO)64.00€Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Formula:C23H29N3OPurity:99.84% - 99.98%Color and Shape:SolidMolecular weight:363.5S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Formula:C20H23N3O2Purity:99.45%Color and Shape:SolidMolecular weight:337.42PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Formula:C18H22N2OPurity:98%Color and Shape:SolidMolecular weight:282.38Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Formula:C27H33NO4Purity:99.89%Color and Shape:SolidMolecular weight:435.56Ref: TM-T13510
1mg46.00€5mg99.00€10mg147.00€25mg222.00€50mg299.00€100mg411.00€200mg553.00€1mL*10mM (DMSO)113.00€DuP 734
CAS:DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].Formula:C17H23BrFNOColor and Shape:SolidMolecular weight:356.279NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Formula:C23H34ClNO2Purity:99.76%Color and Shape:SolidMolecular weight:391.98Ref: TM-T20797
1mg43.00€2mg54.00€5mg87.00€10mg130.00€25mg210.00€50mg313.00€100mg465.00€200mg662.00€500mg982.00€Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formula:C19H23ClFN3OPurity:99.95%Color and Shape:SolidMolecular weight:363.86WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Formula:C21H29N5O3Purity:98%Color and Shape:SolidMolecular weight:399.49Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).
Formula:C20H26ClN3O2Purity:99.6%Color and Shape:SolidMolecular weight:375.89S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFormula:C20H26ClNOPurity:98%Color and Shape:SolidMolecular weight:331.88
